Transvascular diaphragm pacing systems and methods of use

Abstract

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 662,579, filed June 21, 2012, the disclosure of which is expressly incorporated herein by reference. Background technique [0003] Patients in a hospital intensive care unit (ICU) may experience impairment of the ability to breathe willpower due to their underlying disease condition and require positive pressure mechanical ventilation (PPMV) to provide breathing assistance. PPMV is often used in combination with sedation in the ICU to provide artificial respiration in these critically ill patients. In addition, many patients undergoing surgery under general anesthesia (such as in a hospital operating room (OR)) or under anesthesia or sedation (such as in a hospital emergency department (ER)) often have Requires PPMV for respiratory assistance. [0004] Although mechanical breathing is life-sustaining, it interferes with the active contraction of t...

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Problems solved by technology

However, the treatment described in the '215 patent would be useful in the treatment of critically ill patients who still have both ty

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