41 results about "Reproductive disease" patented technology

The present invention provides a vaccine which protects pigs from a virus and/or an infectious agent causing a porcine respiratory and reproductive disease, a method of protecting a pig from a disease caused by a virus and/or an infectious agent which causes a respiratory and reproductive disease, a method of producing a vaccine against a virus and/or an infectious agent causing a porcine reproductive and respiratory disease, and a biologically pure sample of a virus and/or infectious agent associated with a porcine respiratory and reproductive disease, particularly the Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), and an isolated polynucleotide which is at least 90% homologous with a polynucleotide obtained from the genome of a virus and/or infectious agent which causes a porcine respiratory and reproductive disease.

The present invention relates to combination vaccines and methods for treating or preventing diseases or disorders in an animal caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PI₃), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira hardj-prajitno, Leptospira icterohaemmorrhagiae, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a combination vaccine. The combination vaccine can be a whole or partial cell inactivated or modified live preparation.

Applications of cyanidin-3-O-glucoside in preparation of medicines treating and/or preventing diseases caused by 3-chloropropane-1,2-diol are provided. The cyanidin-3-O-glucoside (C3G) can improve rat ingestion decrease and growth retardation which are caused by 3-MCPD poisoning, can effectively resist rat antioxidant system damage caused by 3-MCPD poisoning, and can activate and adjust BTB structural functions of sustentacular cells through inhibiting an MAPK signaling pathway, thus relieving seminiferous epithelium injuries caused by the 3-MCPD, maintaining stability of a spermatogenic microenvironment, regulating spermatogenic cell proliferation and differentiation, and improving dyszoospermia. In addition, the C3G can improve sperm activity through adjusting sperm energy metabolism related enzymes. The C3G can regulate rat sex hormone secretion disorders caused by 3-MCPD poisoning and can maintain normal levels of sex hormone in serum and androgen in testis inner environments. The applications provide theoretical foundations for 3-MCPD reproduction toxicity nutritional intervention utilizing anthocyanin.

The invention belongs to the field of human reproductive disease treatment and assisted reproduction and relates to a novel long-acting follicle stimulating hormone (FSH) and a preparation method and application thereof to assisted reproduction. In the invention, under the double actions of non-covalent combination between an FSH [alpha] subunit and an FSH [beta] subunit and holes type and knobs type Fc knobs-into-holes buckle structures, a stable FSH fusion protein in a form of a heterodimer is folded. The novel long-acting FSH fusion protein provided by the invention not only realizes the goals of keeping the activity of the natural FSH and introducing an Fc fragment to prolong the half-life period of the FSH, but also overcomes the defect of a production process for recombination of the FSH-Fc fusion protein caused by the use of the homologous Fc fragment, thereby having a high practical value.

The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PIV3), Campylobacter fetus, Leptospira canicola, Leptospira grippotyphosa, Leptospira hardj-prajitno, Leptospira icterohaemmorrhagiae, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a safe modified live viral combination vaccine further combined with a multivalent bacterin vaccine.

The invention discloses a GPR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a GPR1 antagonistic polypeptide shown in SEQ ID No.1-3 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a GPR1 binding peptide amino acid side chain group and an amino terminal ora carboxyl terminal of a GPR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the GPR1 antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with GPR1 in vitro, by stopping combination of chemerin and GPR1, increase of the cAMP concentration is promoted, the (Ca2+) influx caused by chemerin is inhibited, proliferation of breast cancer cells can be inhibited, the cell cycle of the breast cancer cells is blocked, apoptosis of the breast cancer cells is promoted, effective micromolecule treatment drugs are provided for female reproductive diseases such as breast cancer, and the GPR1 antagonistic polypeptide can be widely applied in the fields of medicine and biology.

The invention discloses a toxin transforming and bacteria removing Chinese medicine composition for treating reproductive diseases and a preparation method of the Chinese medicine composition. The toxin transforming and bacteria removing Chinese medicine composition for treating the reproductive diseases is mainly prepared with raw materials including, by weight, 35-45 parts of Chinese yam, 35-45 parts of wild chrysanthemum, 35-45 parts of calcined talc schist, 35-45 parts of calcined actinolite, 25-35 parts of epimedium, 25-35 parts of honeysuckle, 25-35 parts of golden cypress, 15-25 parts of china root, 15-25 parts of Szechuan peppers, 15-25 parts of dandelion, 15-25 parts of leonurus, 15-25 parts of atratylodes rhizome, 25-35 parts of herba violae, 25-35 parts of fructus forsythiae, 25-35 parts of areca nut, 35-45 parts of ginseng, 25-35 parts of astragalus, 10-20 parts of red flower, 25-35 parts of spreading hedyotis herb, 10-20 parts of liquorice, 10-20 parts of eupatorium, 15-25 parts of plantain seed, 25-35 parts of dittany bark, 25-35 parts of selinum japenious seed, 25-35 parts of kuh-seng and 65-75 parts of mirabilite. By the aid of the Chinese medicine composition for treating the reproductive diseases, the curative ratio is higher than 90%, the effective rate is 98%, and the recurrence rate of the reproductive diseases treated by a traditional method is reduced from the original 80% to less than 20%, so that the Chinese medicine composition for treating the reproductive diseases has remarkable treatment effects.

The invention relates to an artificial insemination method for breeding rabbit feeding, which comprises the following steps of: preparation in a laboratory, selection of breeding rabbits, preparation before semen collection, processing of seminal liquid, semen deposition and the like. By using the method, the feeding number of male rabbits can be decreased, wastes are reduced, the feeding and management of breeding rabbit crowds are facilitated, the labor productivity is increased, and thus, the feeding cost is decreased and the economic benefit is increased; the utilization rate of excellent breeding male rabbits is improved, because the number of the male rabbits required in artificial insemination is decreased, the selection intensity is enhanced to make full use of the male rabbits with best quality, and an obvious effect of improving the genetic constitution of offspring is achieved; and the male rabbits and the female rabbits are prevented from direct contact, so that the spreading of various diseases, especially reproductive diseases, is prevented.

The invention discloses a CMKLR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a CMKLR1 antagonistic polypeptide shown in SEQ ID No.1-24 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a CMKLR1 binding peptide amino acid side chain group and an amino terminal or a carboxyl terminal of a CMKLR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the CMKLR1antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with CMKLR1 in vitro, by stopping combination of chemerin/RvE1 and CMKLR1, increase of the cAMP concentrationis promoted, the calcium influx caused by chemerin and cell chemotaxis caused by chemerin are inhibited, proliferation of ovarian carcinoma cells can be inhibited, apoptosis of the ovarian carcinoma cells is promoted, and effective micromolecule treatment drugs are provided for female reproductive diseases such as ovarian cancer.

The invention discloses a traditional Chinese medicine feed additive for improving reproductive capacity of male horses, which is prepared by the following method: 15g of morinda officinalis, 10g of cistanchedeserticola, 10g of semen cuscutae, 20g of cinnamon, 60g of Chinese yam, 10g of flatstem milkvetch seed, 20g of monkshood, 20g of dried orange peel, 35g of poriacocos, 40g of Lycium barbarum,10 g of radix rehmanniaepreparata, 30 g of caulis akebiae, 30 g of radix aucklandiae, 30 g of wrinkled gianthyssop herb, 40 g of lotus paste and 100 g of honey. The traditional Chinese medicine feed additive for improving the reproductive capacity of the male horses, provided by the invention, can ensure the reproductive capacity of the male horses and treatment reproductive diseases of the male horses, so that the conception rate of the female horses is increased and the loss is reduced.

The present invention is directed to a system for treating uro-genital conditions. One aspect of this invention involves the treatment system comprising one or more polypeptides with a amino acid sequence including KPV (SEQ. ID. NO. 1), MEHFRWG (SEQ. ID. NO. 2) HFRWGKPV (SEQ. ID. NO. 3), SYSMEHFRWGKPV (SEQ. ID. NO. 4), for treatment of uro-genital conditions. The one or more polypeptides can also be a dimer formed from any of the amino acid sequence above. Uro-genital conditions can include infections, inflammation, or both. In one preferred embodiment of the invention, the uro-genital condition includes infection and/or inflammation of the vagina, vulva, urinary tract, penis, and/or the rectum. In another preferred embodiment of the invention, the one or more polypeptides are dissolved in a carrier. In another preferred embodiment of the invention, the one or more polypeptides are associated with a tampon for preventing toxic shock syndrome. In another preferred embodiment, the one or more polypeptides are associated with a contraceptive for prevention of sexually transmitted diseases or infections. In another preferred embodiment, the one or more polypeptides are associated with a suppository for insertion into the vagina or rectum.

The invention discloses a breeding method for improving the reproductive rate of beef cattle and relates to the technical field of livestock breeding. The method comprises the methods of (1) cattle herd structure adjustment, wherein the adjustment at the end of a year is 80% of basic cattle, 10% of reserved cattle and 10% of bred cattle, (2) breeding control including (a) the selection of high-quality breeding cattle, (b) the nutritional supply of female beef cattle, (c) reproductive disease control, (d) estrus identification and breeding insemination, (3) fetus protection after insemination including feeding management, environmental control and appropriate exercise, (4) pregnancy check and re-examination and secondary insemination, performing pregnancy check after 20 days to 1 month of female cattle insemination, and performing complementary insemination non-pregnant female cattle, and (5) delivery and postpartum care. According to the method, the purpose of improving the reproductive rate of the beef cattle is achieved by the strict control of the living environment of the pregnant cattle, timely insemination and post-natal care and the strengthened management of the aspects ofmaternal health, conception rate, and complementary insemination for non-pregnancy.

The invention discloses a CMKLR1 antagonistic polypeptide and a derivative and application thereof and particularly relates to a CMKLR1 antagonistic polypeptide shown in SEQ ID No.1-15 and a derivative thereof. The derivative of the binding peptide is a product obtained in the mode that conventional modification is conducted on a CMKLR1 binding peptide amino acid side chain group and an amino terminal or a carboxyl terminal of a CMKLR1 antagonistic polypeptide fragment or a product obtained in the mode that a label for detection or purification of polypeptide or protein is linked to the CMKLR1antagonistic polypeptide. The binding peptide and the derivative thereof can be combined with CMKLR1 in vitro, by stopping combination of chemerin/RvE1 and CMKLR1, the cAMP concentration is changed,the calcium influx caused by chemerin and cell chemotaxis caused by chemerin are inhibited, proliferation of ovarian carcinoma cells can be inhibited, apoptosis of the ovarian carcinoma cells is promoted, and effective micromolecule treatment drugs are provided for female reproductive diseases.

The invention discloses a biomarker group and application thereof, and belongs to the technical field of bioengineering. By applying an RNA-seq technology, the result shows that the mRNA expression level of an mt-Nd6 gene in a male reproductive system is lowered, and meanwhile the mRNA expression level of an Slc12a4 gene in the male reproductive system is raised; and therefore, the Slc12a4 gene and the mt-Nd6 gene can serve as the biomarker group for diagnosing male reproductive toxicity caused by prochloraz. By studying the mechanism that prochloraz affects the male reproductive system, the invention provides the biomarker group for diagnosing the male reproductive toxicity caused by prochloraz, the Slc12a4 gene and the mt-Nd6 gene can provide an important basis for preventing and treating male reproductive diseases caused by prochloraz for human, and the study has practical significance.

The invention relates to a traditional Chinese medicine ointment, and in particular, relates to an ointment for treating reproductive diseases. The ointment for treating reproductive diseases comprises the following components in parts by mass: 1-3 parts by mass of musk, 40-60 parts by mass of toad, 40-60 parts by mass of asarum sieboldii, 40-60 parts by mass of tribulus terrestris, 5-15 parts bymass of borneol, 20-40 parts by mass of sulfur, and 100-2000 parts by mass of vaseline. The ointment for treating reproductive diseases can take treatment of reproductive diseases of both men and women into account, and has positive curative effect.

[Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease.

[Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I)

wherein Z represents

wherein n1, n2, and n3 are 0, 1, or 2, respectively; R¹ represents C_1-6 alkyl, C_3-8 cycloalkyl, or the like; R² represents aryl or heteroaryl; R³ represents a hydrogen atom, C_1-6 alkyl, or the like; and M₁, M₂, M₃, and M₄ independently represent a hydrogen atom, C_1-6 alkyl, or the like, or M₁, together with M₂, M₃, or M₄, forms —CH₂— or the like.

The invention discloses rare earth containing gynecological liquid. The gynecological liquid is composed of, by weight, 1-10 parts of rare earth borate, 1-10 parts of propolis, 3-17 parts of honey and 0.3-7 parts of borneol, and solvents are 20-160 parts of water and 10-80 parts of alcohol. The gynecological liquid can be prepared by only dividing raw materials into two parts, respectively adding into water and alcohol for dissolving, mixing two solutions, and stirring well to obtain. A using method of the gynecological liquid includes: directly spraying to an affected part, twice a day; or adding water into the gynecological liquid to dilute for daily nursing and cleaning, at least twice a day. The gynecological liquid can both be directly sprayed to the affected part and be diluted for cleaning and nursing for many times, can diminish inflammation and kill bacteria, is high in penetrability and quick in action and further has functions of moistening and maintaining; by combining characteristics of rare earth elements in promoting efficacy, efficient sterilization and penetration with traditional Chinese medicine, the objectives of simplifying production process and improving efficacy are achieved, and the gynecological liquid has remarkable treatment effect on various men's and women's diseases and reproductive diseases.