13 results about "Reproductive disease" patented technology

Provided are a collection medium and uses thereof for preventing menstrual blood clotting and preserving cell viability in menstrual blood samples. Also provided are methods of using such collection medium for finding novel and potentially diagnostic and prognostic biomarkers in menstrual blood for different gynecological disease such as endometriosis, gynecological cancers, and other non-reproductive diseases. Also included are methods for employing a dye test for distinguishing between living and dead cells in a sample.

The invention discloses an application of SB216763 in improving the in-vitro proliferation capacity of porcine spermatogonium. Therefore, the SB216763 can be used as an additive of the porcine spermatogonial cell in-vitro culture medium, and the porcine spermatogonial cell in-vitro culture medium combined with various growth factors is prepared. Researches show that clone groups of the porcine spermatogonium cultured by the culture medium additionally added with the SB216763 are increased, the number of the clone groups is remarkably increased, the expression quantity of genes related to proliferation is remarkably increased, apoptosis genes are remarkably reduced, and the expression of genes related to reproductive specificity and pluripotent maintenance is also increased, so that the in-vitro proliferation and long-term maintenance of the porcine spermatogonium are improved, and the porcine spermatogonium can be used for preparing a novel culture medium for the porcine spermatogonium. Therefore, the in-vitro culture level of the PSCs is systematically improved. Therefore, the invention provides a reliable basis for establishing a long-term, stable and efficient in-vitro culture system of the porcine spermatogonium, and provides a stable and efficient cell model for gene editing of the porcine spermatogonium, preparation of transgenic animals and research on reproductive diseases; the method also has potential application value in the aspects of genetic improvement of pig breeds or preservation of male germplasm resources.

Compositions and methods of treating or preventing a reproductive disease or condition in a mammalian subject comprising administering to a mammalian subject in need thereof an effective amount of a substantially homogeneous and transformed population of enteric bacterial cells, wherein the administered bacterial cells have been engineered to express bile salt hydrolase (BSH). Compositions and methods for treating or preventing polycystic ovary syndrome (PCOS).

The invention belongs to the technical field of medical auxiliary instruments, and particularly relates to an improved trapezoidal long-laying moxibustion tool which is provided with a rectangular area and a trapezoidal area, so that the improved trapezoidal long-laying moxibustion tool can fully cover the long-laying moxibustion range of a human body during abdominal long-laying moxibustion and can cover perineum acupuncture points such as curved bones needing to be covered for reproductive diseases. The size of the moxibustion laying isolation pad is adjustable, the moxibustion laying isolation pad can be suitable for people of different physiques and sizes, and the arranged overtemperature alarm can remind that the temperature exceeds the standard. Due to the fact that the first flange pressing block set at the top of the rectangular area and the second flange pressing block set and the third flange pressing block set on the two sides of the trapezoidal area are respectively composed of a plurality of independent pressing blocks, the long moxibustion isolation pad can be adaptively bent along with the body surface, and the long moxibustion isolation pad can be well attached to the body surface; and discomfort caused by pressing the ilium of the patient on the two sides is avoided. And the long moxibustion tool is durable, and is convenient to disassemble and clean after being used.

Provided are a collection medium and uses thereof for preventing menstrual blood clotting and preserving cell viability in menstrual blood samples. Also provided are methods of using such collection medium for finding novel and potentially diagnostic and prognostic biomarkers in menstrual blood for different gynecological disease such as endometriosis, gynecological cancers, and other non-reproductive diseases. Also included are methods for employing a dye test for distinguishing between living and dead cells in a sample.

The invention relates to an application of an HK1 gene in mouse ovarian granular cells, in particular to an application in regulating proliferation and apoptosis of the mouse ovarian granular cells and / or steroid hormone synthesis. According to the invention, mouse ovarian granular cells are taken as a research object, and the expression of the HK1 gene is interfered to verify that the HK1 gene is taken as a key target spot for regulating and controlling the functions of the mouse ovarian granular cells so as to influence steroid hormone synthesis and cell proliferation and apoptosis processes. The invention not only provides more reliable technical support for ovarian function regulation, but also provides new thinking and technical guidance for mechanism research of reproductive diseases and preparation and development of related drugs.

The application belongs to the technical field of disease auxiliary diagnosis, and particularly relates to a traditional Chinese medicine reproductive endocrine disease diagnosis auxiliary system based on a clinical knowledge graph. When a reproductive knowledge graph is constructed by integrating the medical records of reproductive disease patients, the collection of patient's pathogenic environment information is increased, and correlation analysis is carried out on the pathogenic environment to identify the risk pathogenic environment. Then, a search platform based on the reproductive knowledge graph is created. Thus, by inputting the patient's pathogenic symptoms and matching the reproductive knowledge graph, it is judged whether the matching is successful. When the matching is successful, the preferred treatment path matched with the patient's symptoms is output. When the matching fails, the patient's pathogenic environment information is input and matched with the reproductive knowledge graph, and then the potential reproductive disease of the patient is output. Thus, the ability of the reproductive knowledge graph in early warning and preventive intervention is improved, and the application value of the auxiliary diagnosis using the reproductive knowledge graph is greatly improved.

The application discloses an endometrium-targeted mitochondrial function compensation system and application thereof. The endometrium-targeted mitochondrial function compensation system comprises a function unit, a delivery unit and a control unit. The function unit comprises a vesicle preparation formed by wrapping donor mitochondria with red blood cell membranes. The donor mitochondria are isolated mitochondria with complete inner and outer mitochondrial membranes and ridge structures or engineered mitochondria carrying exogenous mitochondrial DNA. The application first constructs a comprehensive system integrating biological active ingredients, targeted delivery and intelligent control, can directly and efficiently repair the mitochondrial function of endometrial cells, promote endometrial proliferation, and provides an innovative solution for treating related reproductive diseases. The system has complete design, clear effect and good clinical transformation prospect.

The invention relates to an application of an IDH1 gene in porcine ovarian granular cells, in particular to an application in regulating proliferation and apoptosis of the porcine ovarian granular cells and / or steroid hormone synthesis and / or reproductive performance related gene expression. According to the invention, porcine ovarian granular cells are taken as objects, and the expression of the IDH1 gene is regulated to verify that the IDH1 gene is taken as a key target spot for regulating and controlling the functions of the porcine ovarian granular cells so as to influence steroid hormone synthesis and cell proliferation and apoptosis processes. A new molecular target is provided for improving the reproductive performance of the sow, more reliable technical support is provided for regulating and controlling the ovarian function, and a new thought and technical guidance are provided for mechanism research of reproductive diseases and preparation and development of related drugs.

The invention belongs to the technical field of disease auxiliary diagnosis, and particularly relates to a traditional Chinese medicine reproductive endocrine disease diagnosis auxiliary system based on a clinical knowledge graph. Disease environment information collection of a patient is increased when the reproductive knowledge graph is constructed by integrating medical records of the reproductive disease patient, and correlation analysis is carried out aiming at the disease environment; the method comprises the following steps: inputting a disease symptom of a patient to identify a risk disease environment, creating a search platform based on a reproductive knowledge graph, judging whether the matching is successful or not by matching the input disease symptom of the patient with the reproductive knowledge graph, and outputting an optimal treatment path matched with the symptom of the patient when the matching is successful; and when the matching fails, the disease environment information of the patient is input to be matched with the reproductive knowledge graph, and then the potential reproductive disease of the patient is output, so that the capability of the reproductive knowledge graph in the aspects of early warning and preventive intervention is improved, and the application value of the reproductive knowledge graph for auxiliary diagnosis is greatly improved.

The present invention is directed to anti-activin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for the prevention, diagnosis and treatment of a disease or disorder, such as, e.g., cancer, bone disease, cachexia, fibrotic disease, immune disorders, muscle atrophy, neurological diseases, renal diseases, reproductive diseases, and sarcopenia.

The present invention provides the application of circ-CREBBP in identifying or regulating pig semen quality. The present invention has discovered an important circRNA molecular marker that affects pig semen quality. By detecting the expression level of circ-CREBBP, assisted breeding can be performed for boar semen quality identification and early screening of high-semen-quality boars, selecting individuals with superior semen quality and eliminating individuals with inferior quality, thereby achieving a short-term, low-cost, and high-accuracy breeding of a boar population with excellent semen quality; by regulating the expression of circ-CREBBP, pig sperm motility, ATP content in sperm cells, and sperm survival rate can also be regulated, thereby achieving improved pig semen quality. At the same time, as pigs are a good model for human disease research, circ-CREBBP can also be used as an important molecular target for male reproductive diseases, and further applied to rapid and non-invasive diagnosis of male reproductive diseases and research on improving male sperm motility.

The invention provides application of dibutyl phthalate in construction of a testis injury model. Animal experiments discover that dibutyl phthalate can stably construct a model of damaged testicular tissues of mice at the early stage of adolescence, and can destroy normal growth and development of the testis of the mice, destroy the testosterone secretion function of the testis of the mice, and destroy the blood testosterone barrier and the normal structure of the testicular tissues of the mice. The invention develops new application of dibutyl phthalate, provides a new choice for constructing a mouse testis injury model at the early stage of adolescence, and is beneficial to related research of reproductive diseases.