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Medicinal composition for diminishing inflammation and ease pain and preparation and use thereof

An anti-inflammatory, analgesic and composition technology, which can be used in drug combinations, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., and can solve problems such as liver cell intermediate metabolism and mitochondrial function interference.

Inactive Publication Date: 2008-09-17
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been clarified that 30% to 60% of the R-isomer will be converted into its S-isomer through a coenzyme A thioester intermediate in vivo, and the generation of R-ibuprofen coenzyme A competitively inhibits many dependent Interferes with the intermediate metabolism and mitochondrial function of liver cells

Method used

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  • Medicinal composition for diminishing inflammation and ease pain and preparation and use thereof
  • Medicinal composition for diminishing inflammation and ease pain and preparation and use thereof
  • Medicinal composition for diminishing inflammation and ease pain and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 Lysine Dexibuprofen+codeine phosphate tablet

[0015] prescription:

[0016]

[0017] Preparation:

[0018] Pass lysine dextrobuprofen and microcrystalline cellulose through 80 mesh sieves respectively, mix evenly, and mix with codeine phosphate in an equal amount incremental method, fully stir to make evenly, and set aside; add 50% ethanol solution to In the mixed powder, make soft materials, granulate with a 24-mesh sieve, dry, granulate with a 20-mesh sieve, add micropowder silica gel and CMS-Na, mix well, and press a suitable die to form a tablet.

[0019] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

Embodiment 2

[0020] Embodiment 2: Dexibuprofen arginine+caffeine capsules

[0021] prescription:

[0022]

[0023] Preparation:

[0024] Both arginine dextrobuprofen and caffeine are passed through an 80-mesh sieve, mixed uniformly according to the equal-volume incremental method, then magnesium stearate is added, mixed uniformly, and packaged separately to obtain the product.

[0025] The used capsule shell can be a common capsule or an enteric-coated capsule.

Embodiment 3

[0026] Example 3: Dexibuprofen + Oxycodone Chewable Tablets

[0027] prescription:

[0028]

[0029] Preparation:

[0030] Pass raw and auxiliary materials such as ibuprofen, oxycodone, xylitol, and mannitol through a 80-mesh sieve respectively, and mix them evenly by using an equal-volume increasing method, then add 2% PVP-k30 ethanol solution to make a soft material, and use a 16-mesh sieve Granulate, dry, granulate through a 20-mesh sieve, add other flavoring agents, sweeteners, and glidants, mix evenly, and compress into tablets.

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PUM

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Abstract

The invention provides a medicine composition for inflamination diminishing and pain easing, which is a composition formed by an active component and a medicinal carrier, and the active component is formed by one of right hand ibuprofen, ibuprofen or amino acid salt of right hand ibuprofen, right hand ketoprofen, ketoprofen or amino acid salt of right hand ketoprofen and another backbone pain easing medicine or quill. The preferred composition way: lysine right hand ibuprofen and phosphoric acid codeine, arginine right hand ibuprofen and caffeine, right hand ibuprofen and oxycodone, lysine right hand ketoprofen and hydrocodone, arginine right hand ketoprofen and diphenhydramine. The invention is prepared to various oral preparations to acquire better coordination effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for anti-inflammation and analgesia, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Pain is an unpleasant sensory and emotional experience caused by tissue damage or disease. If the pain persists for more than 3-6 months, it is called chronic pain. Chronic pain is often accompanied by psychological or spiritual changes or even dysfunction. According to statistics, about 30% of adults suffer from pain, and two out of every three outpatients are patients with various pain symptoms or symptoms. There are at least 100 million pain patients in my country. Based on different pathogenesis, pain has different manifestations in various diseases, which brings certain difficulties to clinical pain treatment. Non-steroidal antipyretic analgesics (NSAIDs) and opioids are the most commonly used drugs for the treatment of pain. Non-stero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/522A61K31/485A61K31/198A61K31/192A61P29/00A61K31/138
Inventor 陈卫军
Owner FUKANGREN BIO PHARMA
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