A polyvinyl alcohol/collagen/quaternized chitosan electrospun composite fiber film and a preparing method thereof

Abstract

The invention relates to a polyvinyl alcohol / collagen / quaternized chitosan electrospun composite fiber film and a preparing method thereof, and belongs to the field of medical devices. The method includes firstly evaluating morphology of spinning fibers through adjusting a mass ratio between polyvinyl alcohol and collagen and concentrations so as to determine that the optimum ratio between the polyvinyl alcohol and the collagen is 80:20, and that the optimum concentration is 8%; and then when the concentration of added quaternized chitosan is 5%, preparing the composite fiber film by an electrospinning technique. The composite fiber film is simple and convenient to prepare, has good flexibility and mechanical properties, can rapidly stop bleeding, and can form a protective fiber felt layeron wound surfaces to promote wound healing and prevent bacterial infection, thus healing skin wounds. The composite fiber film also has a bleeding arresting function, a wound healing function, antibacterial and anti-inflammation functions, and the like, is suitable for use as a bleeding arresting material, a wound healing material, and a medical device material, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a composite fiber membrane with functions of antibacterial and anti-inflammation, wound repair and hemostasis and a preparation method thereof. Background technique [0002] Human injury caused by various traumas, burns, surgery and other reasons is a common clinical phenomenon. At present, there are three main categories of medical wound repair materials according to their development: traditional dressings, synthetic repair materials and biological repair materials. At present, bioremediation materials are a kind of relatively advanced medical materials, especially through local supplementation of exogenous cytokines in wounds to achieve healing effects. However, this kind of material generally has some defects: few sources of materials, high price, single performance, slow wound healing and scarring. Traditional dressings with a single function can no longer meet t...

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Problems solved by technology

However, this kind of material generally has some defects: few sources of materials, high price, single performance, slow wound healing and scarring

[0006] At present, the existing collagen hemostatic materials are mostly collagen sponge and gelatin sponge. These materials can quickly absorb blood and turn red during the hemostasis process, and are soaked in blood, but the material is soft and loose after absorbing blood. , it is difficult to fit closely with the bleeding point, and the hemostatic effect is limited

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