A polyvinyl alcohol/collagen/quaternized chitosan electrospun composite fiber film and a preparing method thereof

Abstract

The invention relates to a polyvinyl alcohol/collagen/quaternized chitosan electrostatic spinning composite fiber film and a preparation method thereof, belonging to the field of medical devices. Preparation method: first, by adjusting the mass ratio and concentration of polyvinyl alcohol and collagen, evaluate the morphology of spinning fibers, determine the optimal ratio of polyvinyl alcohol and collagen 80:20, and the optimal concentration of 8%; then, add When the concentration of quaternized chitosan was 5%, the polyvinyl alcohol/collagen/quaternized chitosan electrospun composite fiber membrane was prepared by electrospinning technology. The composite fiber membrane of the present invention is easy to prepare, has good flexibility and mechanical properties, can quickly stop bleeding, and can form a layer of protective fiber mat on the surface of the wound to promote wound repair and prevent bacterial infection, thereby healing skin damage. Hemostasis, antibacterial and anti-inflammatory, wound repair and other functions are very suitable as materials for hemostasis, wound repair, and medical equipment, and have a good application prospect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a composite fiber membrane with functions of antibacterial and anti-inflammation, wound repair and hemostasis and a preparation method thereof. Background technique [0002] Human injury caused by various traumas, burns, surgery and other reasons is a common clinical phenomenon. At present, there are three main categories of medical wound repair materials according to their development: traditional dressings, synthetic repair materials and biological repair materials. At present, bioremediation materials are a kind of relatively advanced medical materials, especially through local supplementation of exogenous cytokines in wounds to achieve healing effects. However, this kind of material generally has some defects: few sources of materials, high price, single performance, slow wound healing and scarring. Traditional dressings with a single function can no longer meet t...

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Problems solved by technology

However, this kind of material generally has some defects: few sources of materials, high price, single performance, slow wound healing and scarring

[0006] At present, the existing collagen hemostatic materials are mostly collagen sponge and gelatin sponge. These materials can quickly absorb blood and turn red during the hemostasis process, and are soaked in blood, but the material is soft and loose after absorbing blood. , it is difficult to fit closely with the bleeding point, and the hemostatic effect is limited

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