Method for preparing antibacterial agent by immobilizing Chinese herbal medicines with attapulgite

A technology of attapulgite and Chinese herbal medicine, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of easy oxidation of Chinese herbal medicine extracts, and achieve good water solubility and thermal stability. properties, realize industrialized production, and have the effect of good thermal stability

Inactive Publication Date: 2020-05-26
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Attapulgite has been listed in the feed additive catalog, but the combination of attapulgite and Chinese herbal medicine extracts, the use of fatty acid glycerides to form a primary encapsulation on the surface of attapul

Method used

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  • Method for preparing antibacterial agent by immobilizing Chinese herbal medicines with attapulgite
  • Method for preparing antibacterial agent by immobilizing Chinese herbal medicines with attapulgite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Spray 5% Scutellaria baicalensis extract relative to the mass fraction of attapulgite on the surface of attapulgite under stirring, then place it in a ball mill, and grind for 30 minutes at a ball-to-material ratio of 1:10. Put the mixed material in a stirring tank, spray 20% hot-melt monoglyceride laurate relative to the mass fraction of attapulgite, and then spray 1% N-trimethyl chitosan oligosaccharide relative to the mass fraction of attapulgite into the mixture The aqueous solution of sugar quaternary ammonium salt is continuously stirred for 30 minutes after spraying, and then it is placed in a roller machine for roller treatment, and the material is dried, crushed, and packaged to obtain the product.

Embodiment 2

[0032] Spray 7.5% Astragalus extract relative to the mass fraction of attapulgite on the surface of attapulgite under stirring, then place it in a ball mill, and grind for 30 minutes at a ball-to-material ratio of 1:10. Put the mixed material in a stirring tank, spray 15% hot-melt monocapric laurate relative to the mass fraction of attapulgite, and then spray 1.5% N-alkylated shell relative to the mass fraction of attapulgite into the mixture The aqueous oligosaccharide quaternary ammonium salt solution was continuously stirred for 30 minutes after spraying, and then it was placed in a counter-roll machine for counter-roll processing, and the material was dried, crushed, and packaged to obtain the product.

Embodiment 3

[0034] Spray 10% astragalus extract relative to the mass fraction of attapulgite on the surface of attapulgite under stirring, then place it in a ball mill, and grind for 30 minutes at a ball-to-material ratio of 1:10. Put the mixed material in a mixing tank, spray 10% glyceryl monomyristate and 10% monoglyceride laurate relative to the mass fraction of attapulgite, and then spray 2% relative to the mass fraction of attapulgite into the mixture The carboxymethylhydroxypropyltrimethylammonium chloride chitosan oligosaccharide aqueous solution is continuously stirred for 30 minutes after spraying, and then it is placed in a roller machine for roller treatment, and the material is dried, crushed, and packaged to obtain the product .

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Abstract

The invention discloses a method for preparing an antibacterial agent by immobilizing Chinese herbal medicines with attapulgite. The method comprises the following steps: spraying Chinese herbal medicine active components on the surface of attapulgite powder while stirring, mechanically grinding, sequentially spraying an aqueous solution of liquid fatty glyceride and quaternized chitosan oligosaccharide, stirring for uniform mixing, and rolling, drying, crushing and packaging the obtained mixture. The Chinese herbal medicine active components with antibacterial activity reside in an attapulgite pore channel structure through mechanochemical action, the fatty glyceride is used for forming primary encapsulation on the surface of attapulgite, secondary encapsulation is achieved through quaternized chitosan oligosaccharide, the obtained attapulgite immobilized Chinese herbal medicine antibacterial agent has good thermal stability, and the defect that Chinese herbal medicine antibacterial active components are poor in thermal stability is overcome.

Description

technical field [0001] The invention relates to a method for preparing an antibacterial agent, in particular to a method for preparing an antibacterial agent by using attapulgite to immobilize Chinese herbal medicine, which is mainly used to replace antibiotics in the livestock and poultry breeding process, and belongs to the field of animal feed. Background technique [0002] Since the discovery of antibiotics, they have played an active role in promoting animal production performance and animal intensive farming. However, with long-term and excessive use, a chain of "use of antibiotics in feed - production of drug-resistant bacteria in animals - food chain transfer - infection of human drug-resistant pathogens" has been formed, posing a potential threat to human health. On July 9, 2019, the Ministry of Agriculture and Rural Affairs officially issued Announcement No. 194, announcing the drug feed additive withdrawal plan and related management policies, clearly proposing a ...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K36/481A61K36/515A61K36/484A61K47/02A61K47/14A61K47/26A61K47/36A61P31/04A23K10/30A23K20/28A23K20/158A23K20/163A23K40/30A61K31/7048
CPCA61K36/539A61K36/481A61K36/355A61K36/515A61K36/195A61K36/315A61K36/484A61K31/7048A61K47/02A61K47/14A61K47/26A61K47/36A61P31/04A23K10/30A23K20/28A23K20/158A23K20/163A23K40/30A61K2300/00
Inventor 王爱勤惠爱平黄正君杨芳芳康玉茹许江
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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