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Nano-antibacterial coating preparation method based on quaternized chitosan half-bred micelles

A technology of quaternized chitosan and antibacterial coating, which is applied in the direction of coating, electrolytic coating, electrophoretic plating, etc., can solve the problems of hindering the biochemical action and physiological function of bacteria, and achieve strong practicability and applicability. The effect of abundant sources and low experimental cost

Inactive Publication Date: 2016-10-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, metal ions with antibacterial effects can also react with some functional groups of proteins and nucleic acids, and even enter microbial cells to react with biological enzymes, hindering the normal biochemical and physiological functions of bacteria

Method used

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  • Nano-antibacterial coating preparation method based on quaternized chitosan half-bred micelles
  • Nano-antibacterial coating preparation method based on quaternized chitosan half-bred micelles
  • Nano-antibacterial coating preparation method based on quaternized chitosan half-bred micelles

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Effect test

Embodiment 1

[0019] A method for preparing a nano-antibacterial coating based on quaternized chitosan hybrid micelles, the specific preparation steps are as follows:

[0020] (1) Preparation of hybrid micellar solution: quaternized chitosan was dissolved in 1% glacial acetic acid aqueous solution to form a 3 mg / mL quaternized chitosan solution, and L-cysteine ​​was dissolved in water Form a 3mg / mL L-cysteine ​​solution, mix the prepared two solutions in equal volumes, add a certain amount of nano-zinc oxide, so that the concentration of nano-zinc oxide is 0.8mg / mL, keep stirring, and after mixing evenly, adjust The pH of the above mixed solution is 6, which promotes the self-assembly of quaternized chitosan, small molecule L-cysteine ​​and nano-zinc oxide, and continues to stir for 10 minutes to fix the hybrid micelle morphology and obtain a hybrid micelle solution , the digital photo of the sample and the topography in the dry state are attached figure 1 shown.

[0021] (2) Preparation ...

Embodiment 2

[0023] A method for preparing a nano-antibacterial coating based on quaternized chitosan hybrid micelles, the specific steps are as follows:

[0024] (1) Preparation of hybrid micellar solution: quaternized chitosan was dissolved in 1% glacial acetic acid aqueous solution to form a 3 mg / mL quaternized chitosan solution, and L-cysteine ​​was dissolved in water Form a 5 mg / mL L-cysteine ​​solution, mix the prepared two solutions at a volume ratio of 1:2, add a certain amount of nano-zinc oxide so that the concentration of nano-zinc oxide is 1.0 mg / mL, keep stirring, and wait to mix After uniformity, adjust the pH=7 of the above-mentioned mixed solution to promote the self-assembly of quaternized chitosan, small molecule L-cysteine ​​and nano-zinc oxide, and continue to stir for 20 minutes to fix the hybrid micelle morphology and obtain the hybrid micelle. micelle solution.

[0025] (2) Preparation of nanometer antibacterial coating: first, the cobalt-based alloy is ultrasonical...

Embodiment 3

[0027] A method for preparing a nano-antibacterial coating based on quaternized chitosan hybrid micelles, the specific steps are as follows:

[0028] (1) Preparation of hybrid micellar solution: quaternized chitosan was dissolved in 1% glacial acetic acid aqueous solution to form a 5 mg / mL quaternized chitosan solution, and L-cysteine ​​was dissolved in water Form a 3mg / mL L-cysteine ​​solution, mix the prepared two solutions at a volume ratio of 1:3, add a certain amount of nano-zinc oxide so that the concentration of nano-zinc oxide is 3mg / mL, continue to stir, and mix evenly Afterwards, adjust the pH=8 of the above-mentioned mixed solution to promote the self-assembly of quaternized chitosan, small molecule L-cysteine ​​and nano-zinc oxide, and continue to stir for 30 minutes to fix the hybrid micelle morphology and obtain a hybrid micellar solution.

[0029] (2) Preparation of nano-antibacterial coating: first, 316L stainless steel was ultrasonically cleaned with acetone ...

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Abstract

The invention relates to a nano-antibacterial coating preparation method based on quaternized chitosan half-bred micelles. The preparation method includes the steps that firstly, quaternized chitosan is dissolved in 1% glacial acetic acid water solution to obtain a quaternized chitosan solution, then L-cysteine is dissolved in water to prepare an L-cysteine water solution, the two prepared solutions are mixed, a certain amount of solid nanozinc oxide is added, continuous stirring is performed, a pH value of the solution is regulated to promote system self-assembly after even mixing, and a half-bred micelle solution is obtained; finally, the half-bred micelle solution is used as electrolytic solution, the half-bred micelles are fixed to the medical metal surface by combining with an electrophoretic deposition technology to form a nano antibacterial coating. The nano-antibacterial coating preparation method is simple and convenient to operate, low in cost and wide in application range.

Description

technical field [0001] The invention relates to a method for preparing a nano-antibacterial coating based on quaternized chitosan hybrid micelles, which belongs to the field of combining natural polymers and antibacterial coatings, and is also an organic-inorganic hybrid system. technical background [0002] Studies have shown that the formation of antibacterial coatings on the surface of orthopedic implants has a good inhibitory effect on bacterial adhesion and biofilm formation, providing a new research direction for the clinical prevention of orthopedic implant surgical infection. As the only positively charged polysaccharide in nature, chitosan has excellent antibacterial properties, but it can only obtain good solubility and antibacterial effect under acidic conditions, and its antibacterial ability is limited to a certain extent. In contrast, chitosan quaternary ammonium salt not only has the properties of typical quaternary ammonium salts, such as antibacterial, antib...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/30A61L27/50C25D13/00
CPCA61L27/34A61L27/306A61L27/50A61L2420/02A61L2420/04C25D13/00C08L5/08
Inventor 刘晓亚石甜甜孙家娣朱叶顾瑶孟龙
Owner JIANGNAN UNIV
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