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30 results about "Molecular charge" patented technology

Quaternized chitosan/siRNA (small interfering Ribonucleic Acid) composite particles and preparation method thereof

The invention discloses quaternized chitosan/siRNA (small interfering Ribonucleic Acid) composite particles and a preparation method thereof. Electrostatic interaction between a quaternary ammonium group with positive charges and a siRNA molecule with negative charges on quaternized chitosan is used as driving power; molecule self-assembly is initiated in a water phase through vortex oscillation; and the high-bioactivity quaternized chitosan/siRNA composite particles with controllable size and surface charge are prepared by adjusting and controlling parameters such as molecular charge ratio, incubation temperature and incubation time. According to the quaternized chitosan/siRNA composite particles and the preparation method thereof, the quaternized chitosan is used as a siRNA transfer carrier, and the material has low cytotoxicity, wide source and low cost; a preparation process of the composite particles has mild conditions and is simple and practical; and the bioactivity of the siRNA can be effectively kept. The siRNA used for preparing the composite particles can be effectively intaken by cells and a mum effect of the target gene can be induced aiming at specific design of a target gene; and the composite particles have good application prospect in the fields of cancer treatment, tissue regeneration and repair and the like.
Owner:ZHEJIANG UNIV

Flexible circuit three-dimensional printing device for high-molecular liquid-state metal co-printing

The invention discloses a flexible circuit three-dimensional printing device for high-molecular liquid-state metal co-printing. The flexible circuit three-dimensional printing device comprises a mounting framework, a coaxial spray head mounted in the mounting framework, a material supply device, a receiving device and a three-dimensional motion mechanism for driving the coaxial spray head to perform three-dimensional motion relative to the receiving device, and further comprises an auxiliary curing device which synchronously moves with the coaxial spray head to spray printed and discharged materials. The flexible circuit three-dimensional printing device is characterized in that the coaxial spray head comprises inner and outer liquid-state metal charge cavity and high-molecular charge cavity which are independent from each other, and an inner spray head and an outer spray head which communicate with corresponding guide cavities separately and are coaxially arranged. XYZE four-axis motion is utilized for realizing printing of a three-dimensional structure, and the auxiliary curing device, a heating device and a bearing unit convenient for separating printed products solve the problem that a silica gel material is difficult in curing and is difficult to separate. The flexible circuit three-dimensional printing device is convenient to operate, and can quickly and directly print out a complete three-dimensional flexible circuit structure with liquid-state metal therein.
Owner:ZHEJIANG UNIV

Modified peptides with antiviral properties and methods for obtaining them

This invention may be used in human and veterinary medicine for the creation of a drug that is effective perorally in the treatment of many viral infections, such as influenza, herpes, and cytomegalovirus.Summary of the InventionModified peptides with antiviral properties and methods for obtaining them, distinct in that in the capacity of the main active ingredient, a mixture (assembly) of oligopeptides is used that are the products of the hydrolysis of proteins with changes in their molecular charges to the opposite are used, and to obtain them, first a partial hydrolysis of protein-containing raw material is conducted, and then a process of chemical modification of the quantity of oligopeptides obtained with a change in the charge to the molecules is conducted; this is used as an antiviral vehicle for the composition of the oligopeptides obtained. This quantity of modified oligopeptides is capable of slowing down the activity of the heterodimer of b-importin cells and slowing the replication of viruses whose replication cycle depends on the function of the nucleus.An assembly of modified oligopeptides based on a quasi-life, dynamic, self-organizing system that is effective in the treatment of viral infections such as influenza, herpes, and animal viruses at all stages of the development of the infectious process where other drugs are ineffective. This drug has a wide spectrum of activity and a low level of toxicity; it is accessible for industrial production and effective at any stage of the viral replication cycle that depends on cell nuclei.
Owner:MARTYNOV ARTUR +2

Multifunctional recovery physiotherapy instrument of novel polarization oscillation wave depth thermotherapy

The present invention discloses a multifunctional recovery physiotherapy instrument of novel polarization oscillation wave depth thermotherapy. The multifunctional recovery physiotherapy instrument comprises a high frequency oscillation generator connected with a hand-held electrode and a pedal electrode, and an oscillation wave is introduced from the feet, the hands or other parts of a human body via the electrodes, so that a polarization oscillation energy wave similar to the pulse discharge between the capacitor plates is formed between the two electrodes, and accordingly, the human body cell molecular charges generate a polarization displacement heat effect to form the depth thermotherapy. The heat is generated by the cell resonance, so that the body depth heating is more uniform, the human body does not feel discomfort when the temperature in the body rises to 42 DEG C, and the body lesion location can be heated directionally and effectively, and accordingly, the unique effects of killing viruses, eliminating inflammation, restraining tumors and cancer cells, etc., are realized. The multifunctional recovery physiotherapy instrument can be widely suitable for the treatment of various inflammations and tumors, is small in size and remarkable in curative effect, is simple and convenient to use and operate, is safe and reliable, is suitable for being used at the places, such as the hospitals, the health centers, nursing homes, etc., and has a great practical value.
Owner:江门市富美康保健仪器科技有限公司

A new type of multifunctional rehabilitation physiotherapy instrument for deep hyperthermia with polarized oscillatory waves

The present invention discloses a multifunctional recovery physiotherapy instrument of novel polarization oscillation wave depth thermotherapy. The multifunctional recovery physiotherapy instrument comprises a high frequency oscillation generator connected with a hand-held electrode and a pedal electrode, and an oscillation wave is introduced from the feet, the hands or other parts of a human body via the electrodes, so that a polarization oscillation energy wave similar to the pulse discharge between the capacitor plates is formed between the two electrodes, and accordingly, the human body cell molecular charges generate a polarization displacement heat effect to form the depth thermotherapy. The heat is generated by the cell resonance, so that the body depth heating is more uniform, the human body does not feel discomfort when the temperature in the body rises to 42 DEG C, and the body lesion location can be heated directionally and effectively, and accordingly, the unique effects of killing viruses, eliminating inflammation, restraining tumors and cancer cells, etc., are realized. The multifunctional recovery physiotherapy instrument can be widely suitable for the treatment of various inflammations and tumors, is small in size and remarkable in curative effect, is simple and convenient to use and operate, is safe and reliable, is suitable for being used at the places, such as the hospitals, the health centers, nursing homes, etc., and has a great practical value.
Owner:江门市富美康保健仪器科技有限公司
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