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Quaternized chitosan fibers and moisture-absorbing antibacterial wound dressing

A technology of quaternized chitosan and chitosan fiber, which is applied in the field of medical materials and can solve problems such as increased hygroscopicity, decreased wet strength of fibers or dressings, etc.

Inactive Publication Date: 2016-01-13
FOSHAN UNITED MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these modifications are all connected to the chitosan molecular chain with a hydrophilic group with strong water absorption, which increases the hygroscopicity and also makes the wet strength of the fiber or dressing drop sharply.

Method used

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  • Quaternized chitosan fibers and moisture-absorbing antibacterial wound dressing
  • Quaternized chitosan fibers and moisture-absorbing antibacterial wound dressing
  • Quaternized chitosan fibers and moisture-absorbing antibacterial wound dressing

Examples

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preparation example Construction

[0044] The preparation of quaternized chitosan fiber is to use ordinary chitosan fiber as raw material, react with a certain proportion of 2,3-epoxypropyltrimethylammonium chloride, the polarity of the prepared fiber increases, It overcomes the disadvantages of poor hydrophilicity and non-hygroscopicity of ordinary chitosan fibers; moreover, the prepared fibers have high strength and good spinnability, and the dressings obtained have certain bactericidal ability, opening up another kind of dressing except silver-containing dressings. Antibacterial dressings, the following will introduce quaternized chitosan fibers and hygroscopic antibacterial wound dressings in combination with specific examples.

[0045] For the moisture absorption test, refer to the first part of YY / T0471.1-2004; for the antibacterial test, refer to the content of Appendix C5 of GB15979-2002.

[0046] The wet strength test is carried out according to the following method:

[0047] 1) Cut wound dressing sam...

Embodiment 1

[0054] Get 200 grams of 2,3-epoxypropyltrimethylammonium chloride, stir and dissolve with 500 milliliters of absolute alcohol, then transfer to a 1000 milliliter round-bottomed flask, add 200 grams of chitosan fiber length to the solution Tow (linear density 2.1dtex), heat and reflux at 80°C for 2 hours, take out the fiber, wash it twice in an anhydrous alcohol solution containing Tween 20, and dry it to obtain the reacted quaternized chitosan fiber.

[0055] After the above-mentioned quaternized chitosan fiber is cut into short fibers, fiber opening, carding, net laying, acupuncture, cutting and slitting, packaging and sterilization are carried out to obtain a quaternized chitosan dressing with hygroscopicity. and wet strength were 18g / 100cm 2 and 2.8N / cm.

Embodiment 2

[0057] Get 200 grams of 2,3-epoxypropyltrimethylammonium chloride, and stir and dissolve with 500 milliliters of dehydrated alcohol, then transfer in the round bottom flask of 1000 milliliters, add the chitosan fiber of 200 grams in the solution, Heat and reflux at 80° C. for 3.5 hours, take out the fibers, fully wash twice in an absolute alcohol solution containing Tween 20, and dry to obtain reacted quaternized chitosan fibers.

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Abstract

The invention belongs to the technical field of medical materials, and discloses a moisture-absorbing antibacterial wound dressing. The dressing comprises quaternized chitosan fiber fabric. The substitution degree of quaternized chitosan fibers is 0.1-1.0. The quaternized chitosan fibers are prepared through the following steps that 1, a quaternization reagent is dissolved in anhydrous alcohol or propyl alcohol to obtain a quaternization solution; 2, chitosan fibers are soaked in the quaternization solution and reacted for 1-10 h at 50-100 DEG C; 3, after the reaction is finished, washing and drying are performed to obtain the quaternized chitosan fibers. According to the moisture-absorbing antibacterial wound dressing, while antibacterial performance is improved, moisture absorption is improved, and high wet strength is maintained.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a quaternized chitosan fiber and a hygroscopic and antibacterial wound dressing. Background technique [0002] With the improvement of people's living standard and the change of lifestyle, the human disease spectrum presents some new characteristics. Chronic exudative wounds such as venous ulcers, arterial ulcers, diabetic ulcers, traumatic ulcers, and pressure ulcers caused by diabetes, pressure sores, decubitus ulcers, and hypertension have seriously affected people's health. Exudative wounds, as the name suggests, are a type of chronic wounds that secrete a large amount of exudate, and the main components of the exudate are some pus, tissue fluid, and some necrotic tissues and cells. Therefore, in the care of chronic exudative wounds, in addition to fully absorbing wound exudate and providing a warm and moist healing environment for wound healing, anti-infection car...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44D06M13/463D06M101/02
Inventor 陶炳志王晓东王锐
Owner FOSHAN UNITED MEDICAL TECH
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