Application of patchoulicalcohol in preparation of medicines for treating gastric motility disorders

A technology of gastrointestinal motility disorder and patchouli alcohol, which is applied to the application field of medicine or health care products, can solve the problems of poor drug pertinence, unclear synergistic effect, large dosage of traditional Chinese medicine, etc., and achieves good promotion and application prospects and guarantees Wide application, high safety effect

Inactive Publication Date: 2015-01-28
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Like previous related reports, this patent only focuses on traditional Chinese medicine compositions or traditional Chinese medicine or Chinese medicine extracts. It is not clear whether a

Method used

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  • Application of patchoulicalcohol in preparation of medicines for treating gastric motility disorders
  • Application of patchoulicalcohol in preparation of medicines for treating gastric motility disorders
  • Application of patchoulicalcohol in preparation of medicines for treating gastric motility disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Changes of Patchouli Alcohol on the Kinetics of Mouse Isolated Stomach

[0037] 1. Materials and methods

[0038] (1) Reagents

[0039]Krebs solution (Krebs’ Buffer) is freshly prepared, and its components and concentrations are as follows: sodium chloride (NaCl) 118mmol / L, potassium chloride (KCl) 4.75mmol / L, magnesium sulfate (MgSO 4 ) 1.18mmol / L, potassium dihydrogen phosphate (KH 2 PO 4 ) 1.18mmol / L, sodium bicarbonate (NaHCO 3 ) 24.8mmol / L, glucose (C 6 h 12 o 6 ) 10.0mmol / L, calcium chloride (CaCl 2 ) 2.5mmol / L, and the pH value is 7.40.

[0040] Patchouli alcohol was formulated into different concentrations with Krebs solution (10 -7 ~10 -3 M) Spare.

[0041] (2) Experimental device

[0042] The 5mL organ incubation tank was filled with freshly prepared Krebs solution, and the water heated by the constant temperature water tank was circulated in the water bath jacket of the incubation tank to maintain the temperature of the Krebs solution...

Embodiment 2

[0048] Example 2 Changes of Patchouli Alcohol on the Kinetics of the Isolated Large Intestine of Rats

[0049] 1. Materials and methods

[0050] Both the Krebs solution and the patchouli alcohol solution were freshly prepared, and the components and concentrations were the same as in Example 1.

[0051] Take rat large intestine tissue smooth muscle strips (width 1-2 mm, length 3.5-5 mm), the experimental equipment and experimental procedures used for muscle strip fixation, balance and stimulation are the same as in Example 1.

[0052] 2. Results

[0053] Compared with the baseline control, 5.0×10 -4 M and 1.0×10 -3 M concentration of patchouli alcohol can not only inhibit the contraction of rat large intestine smooth muscle, but also inhibit the relaxation of rat large intestine smooth muscle, the frequency and amplitude of the relaxation and contraction are reduced (see attached Figure 4 shown).

Embodiment 3

[0054] Example 3 Intracellular recording experiment of nerve-muscle junction potential in mouse gastric tissue

[0055] 1. Materials and methods

[0056] (1) Both the Krebs solution and the patchouli alcohol solution were freshly prepared, and the components and concentrations were the same as in Example 1.

[0057] (2) Experimental steps

[0058] The mouse gastric smooth muscle layer tissue was fixed in the recording bath with thin steel needles, and the intracellular current injection and connection potential were recorded with a fiberglass microelectrode pipette probe. In a non-acetylcholine and non-norepinephrine (NANC) environment, the electric field stimulation was set to 10 pulses, 20HZ, 70V. Electric field stimulation induces two kinds of inhibitory action potentials, fast inhibitory junction potential (fast IJP) and slow inhibitory junction potential (slow inhibitory junction potential, slow IJP). The concentration of patchouli alcohol is 5.0×10 -4 M. The numbe...

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Abstract

The invention discloses a new use of patchoulicalcohol, that is, an application of patchoulicalcohol in the preparation of medicines or health products for preventing and treating gastric motility disorders. Researches in the invention show that patchoulicalcohol can inhibit the contraction of gastrointestinal smooth muscles, can inhibit the relaxation of the gastrointestinal smooth muscle, and can reduce the overall tension level of the gastrointestinal smooth muscles; and patchoulicalcohol can selectively block the nerve conduction of the smooth muscles, has a significant curative effect on gastrointestinal motility disorders, and is dose dependent. The invention provides a new medicine choice for the gastrointestinal motility disorders, and also provides a new research approach to explore gastrointestinal nerve conduction antagonists. Patchoulicalcohol has no dose toxicity or genetic toxicity and is highly safe, so the daily application dosage is not strictly restricted from a security point of view, the dosage can be adjusted according to practical conditions, so the wide application of patchoulicalcohol is guaranteed, and patchoulicalcohol has a very good popularization application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of patchouli alcohol in the preparation of medicines or health products for treating gastrointestinal motility disorders. Background technique [0002] Gastrointestinal motility disorders are a large category of functional digestive diseases. About 60% of outpatients in the gastroenterology department belong to this type of disease. Common gastrointestinal motility disorders such as functional dyspepsia account for 30-40% of gastroenterology outpatient clinics, and 60-80% of patients have gastrointestinal motility abnormalities or disorders. Another example, irritable bowel syndrome (irritable bowel syndrome, IBS) is also a common chronic gastrointestinal motility disorder, the prevalence of IBS in European and American countries is 5-25%, and the prevalence of IBS in my country is 10%. %. IBS is a group of clinical syndromes including abdom...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61K33/26A61K33/12A61K33/06A61K31/7048A61K31/4375A61K31/352A61K31/11A61K36/258A61K31/715A61P1/12A61P29/00A61P21/00
Inventor 谈博操红缨黄萍苏子仁赖小平
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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