Prokineticin polypeptides, related compositions and methods

a technology of prokineticin and polypeptide, applied in the field of prokineticin polypeptide, related compositions and methods, can solve the problems of reducing the efficacy of these regulators as therapeutics, limiting the utility of these regulators for therapeutic use, etc., and achieve the effect of inhibiting promoting the production of prokineticin receptor signals
US20050074758A1Inactive Publication Date: 2005-04-07RGT UNIV OF CALIFORNIA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
RGT UNIV OF CALIFORNIA
Publication Date
2005-04-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.
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Description

BACKGROUND OF THE INVENTION

[0001] The main function of gastrointestinal (GI) smooth muscle is to mix and propel intralumenal contents, which enables efficient digestion of food, progressive absorption of nutrients, and eventual evacuation of residual components. The activity of GI smooth muscle is regulated by intrinsic and extrinsic neural signals, including classical neurotransmitters, co-existing neuropeptides, and circulating peptide hormones. In addition, a number of humoral agents including histamine, serotonin, and adenosine that are produced by nonneural GI cells also influence the activity of smooth muscle cells.

[0002] A number of clinical conditions are associated with altered GI motility, including irritable bowel syndrome, diabetic gastroparesis, postoperational ileus, chronic constipation, gastrointestinal reflux disease, chronic diarrhea, infectious diseases, malabsorptive disorders, inflammatory bowel disorders, and intestinal cancers. The identification of regulato...

Claims

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