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Polysubstituted indole bithiophene and derivative and synthesis method thereof
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A synthetic method and multi-substitution technology, applied in the field of organic compound synthesis, can solve problems such as complex synthesis steps, achieve the effects of saving raw materials, cheap and easy-to-obtain reaction raw materials, and reducing environmental pollution
Active Publication Date: 2017-10-10
XIANGTAN UNIV
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The existing methods for synthesizing such compounds have complex synthesis steps, which require multi-step synthesis processes to complete, and need to add transition metal catalysts, stoichiometric metal oxidants, etc.
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Embodiment 1-46
[0089] Step 1: Add indole compounds (see Table 1 for specific substances), alkene (alkynes, ketones) compounds (see Table 1 for specific substances) and sulfurpowder into the reaction vessel, and add Bronsted acid (see Table 1 for specific substances) ) solution can also be added to the reaction vessel in the container respectively to Bronsted acid (see Table 1 for specific substances) and organic solvent (see Table 1 for specific substances);
[0090] Step 2: The reaction vessel is evenly heated (such as heating in an oil bath) to the temperature described in Table 1, and the indole compounds, alkene (yne, ketone) compounds and sulfurpowder are reacted in a solvent, and continue in Table 1. the time mentioned;
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Abstract
The invention relates to polysubstituted indole bithiophene and a derivative and a synthesis method thereof. The technical scheme which is adopted for the first time includes that indole compounds, alkene, alkyne and ketone compounds and sulfurpowder are converted into 2-substituted thieno[2,3-b]indole and the derivative in an air atmosphere under catalysis of Bronsted acid, and a product and additional products stable in molecular structure and excellent in chemical property are obtained, raw reaction materials are cheap and easy to acquire without pretreatment, and high reaction atom economy is achieved; the reaction only requires utilization of cheap Bronsted acid, so that environment pollution abatement, raw material saving and reaction cost reduction are realized; the whole reaction system is simple, reaction conditions are mild, a small quantity of reaction devices are adopted, and simplicity and convenience in experiment operation and extensive material sources are realized.
Description
technical field [0001] The invention relates to a multi-substituted indolothiophene and its derivatives and a synthesis method thereof, belonging to the technical field of organic compound synthesis. Background technique [0002] Thieno[2,3-b]indole and its derivatives are an important class of aromatic heterocyclic compounds, which contain a large conjugated system and strong intramolecular electron transfer in the molecule. This special rigid fused ring structure The thieno[2,3-b]indole compounds exhibit many unique properties and biological activities, and have potential applications in many fields such as optoelectronic materials, dyes, medicine, and supramolecular recognition. The existing methods for synthesizing such compounds have the disadvantages of complex synthesis steps, multi-step synthesis processes, and the addition of transition metal catalysts and stoichiometric metal oxidants. Contents of the invention [0003] In order to fill the gap in the prior art,...
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