The invention provides a pathological specimen information processing method, system and device and a medium, and the method comprises the following steps: obtaining doctor's advice information of a patient, and generating initial specimen information of a pathological specimen; updating the initial specimen information according to the nodes of the pathological specimen in the conveying process to obtain specimen label information; generating registration information of the pathological specimen according to the doctor's advice information; verifying the registration information, and generating a pathological number of the specimen information and hospital discharge pre-information of the patient after verification is confirmed to be passed; associating the plurality of pathological specimens to the patient according to the pathological number, and generating a pathological report of the patient; according to the scheme, electronic management of the endoscopic pathological specimens can be achieved, the endoscopic pathological specimen management business process is reconstructed, the key problems of specimen label simplification, expense missing, terminal confirmation, paper record sheet electronization, process traceability and the like in the information transmission process are solved, and the method can be widely applied to the technical field of informatization management.