Composition with functions of preventing hair loss, promoting hair growth and controlling oil and preparation method thereof

Abstract

The invention relates to the technical field of hair preparations, in particular to a composition with hair loss prevention, hair growth and oil control functions and a preparation method of the composition. The composition is prepared from the following raw materials: diaminopyrimidine oxide, a yeast / zinc fermentation product, nicotinamide, lactobacillus / soybean milk fermentation product filtrate combined with PPG-13-decyl tetradecanol polyether-24, PPG-70 polyglycerol-10 ether, an African melia azedarach bark extract, a rhizoma anemarrhenae root extract, a ginseng root extract, a ginger root extract, a polygonum multiflorum root extract, a humectant, an emollient and water. The composition has excellent anti-hair loss and oil control effects, is high in stability and can still exist stably in a high-temperature environment.

Description

Technical Field

[0001] The invention relates to the technical field of hair preparations, and in particular to a composition with the functions of preventing hair loss, promoting hair growth and controlling oil, and a preparation method thereof. Background Art

[0002] The hair follicle is a bag-like epithelium formed by continuous epidermal cells; its base is the dermal papilla that is recessed in the dermis, with a hair in the center. One side of the arrector pili muscle is obliquely attached to the wall of the hair follicle. Above the attachment point is the short neck of the sebaceous gland that enters the hair follicle. The opening of the hair follicle on the skin surface is the follicle pore; the hair follicle is located in the dermis and subcutaneous tissue and can be divided into the follicle infundibulum, follicle isthmus and lower part of the hair follicle. Hair grows out of the follicle, and the hair absorbs nutrients from the body through the follicle to support hair growth. The epithelial cells of the hair follicle tissue can divide and reproduce, so that the hair is constantly replaced and grows, but with age, the function of the hair follicle gradually weakens, and hair loss occurs.

[0003] Hair loss is mainly caused by damage or death of hair follicles due to external stimulation. The quality of current anti-hair loss products is uneven, the anti-hair loss effect is not obvious, and they often have irritation to the skin and unstable emulsion types. Therefore, it is an urgent technical problem to provide a composition with excellent anti-hair loss, hair growth and oil control functions and good stability. Summary of the invention

[0004] The present invention aims at the above technical problems and proposes a technical solution of the present invention. The technical solution of the present invention includes a composition with the functions of preventing hair loss, promoting hair growth and controlling oil and a preparation method thereof.

[0005] The invention provides a composition with the functions of preventing hair loss, promoting hair growth and controlling oil. The raw materials include diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide and lactobacillus / soybean milk fermentation product filtrate.

[0006] Preferably, the composition further comprises PPG-13-decyltetradecyl alcohol polyether-24 and PPG-70 polyglyceryl-10 ether.

[0007] Preferably, the composition further comprises African neem bark extract, Anemarrhena root extract, Ginseng root extract, Ginger root extract and Polygonum multiflorum root extract.

[0008] Preferably, the composition further comprises water, a moisturizer and an emollient.

[0009] Preferably, the composition comprises, by mass percentage, 0.05-1.2% diaminopyrimidine oxide, 0.05-2% yeast / zinc fermentation product, 0.05-0.5% niacinamide, 0.05-1.5% lactobacillus / soymilk fermentation product filtrate, 1-5% PPG-13-decyltetradecyl alcohol polyether-24, 1-3% PPG-70 polyglycerol-10 ether, 0.05-2% neem bark extract, 0.05-1.5% Anemarrhena asphodeloides root extract, 0.05-1.5% ginseng root extract, 0.05-1.5% ginger root extract, 0.05-1.5% Polygonum multiflorum root extract, 4-12% humectant, 4-10% emollient and the remainder water.

[0010] The present invention adopts diaminopyrimidine oxide, yeast / zinc fermentation product, lactobacillus / soy milk fermentation product filtrate, African neem bark extract, Anemarrhena root extract, Ginseng root extract, Ginger root extract, Polygonum multiflorum root extract which have the effects of preventing hair loss and promoting hair growth and controlling oil as raw materials, and endows the composition with the effects of preventing hair loss and promoting hair growth and controlling oil.

[0011] Preferably, in the composition, the mass ratio of PPG-13-decyltetradecanol polyether-24 to PPG-70 polyglycerol-10 ether is 1.2-2.5: 1. The combination of the two can effectively promote and deliver the active ingredients of the composition to the skin of the recipient and effectively promote the effect of the active ingredients, while also giving the composition excellent stability.

[0012] Preferably, in the composition, the moisturizer includes at least one of glycerin, propylene glycol, ethylene glycol, butylene glycol, 1,2-hexanediol, dextran, and sodium hyaluronate.

[0013] Preferably, in the composition, the emollient comprises at least one of phytosterol / octyldodecyl lauroyl glutamate, coconut oil, avocado oil, hydrogenated palm oil, camellia oil and jojoba oil.

[0014] Preferably, in the composition, the mass ratio of diaminopyrimidine oxide to African neem bark extract is 1:0.6-1.2. Diaminopyrimidine oxide and African neem bark extract in the composition can better enhance the effect of the composition in preventing hair loss, and endow the composition with excellent anti-hair loss and hair growth effects.

[0015] Preferably, the composition further comprises at least one of a preservative, a pigment, a flavor, a chelating agent, and a pH adjuster.

[0016] Preferably, the amount of the preservative in the composition is 0.01-0.4%. The preservative may be at least one of phenoxyethanol and benzoate.

[0017] Preferably, the pigment is used in an amount of 0.005-0.1% in the composition.

[0018] Preferably, the amount of fragrance in the composition is 0.005-0.1%.

[0019] Preferably, the amount of the chelating agent in the composition is 0.05-1%. The chelating agent may be at least one of EDTA and its salts and citrate.

[0020] Preferably, the amount of the pH regulator in the composition is 0.1-1%. The pH regulator can be at least one of citric acid, malic acid, lactic acid, and tartaric acid.

[0021] The present invention also provides a method for preparing the composition, comprising mixing raw materials to obtain the composition.

[0022] Preferably, the preparation method further comprises a sterilization step.

[0023] The present invention also provides the use of the composition in preparing cosmetics or hair pharmaceutical preparations.

[0024] Beneficial effects of the present invention:

[0025] The present invention adopts diaminopyrimidine oxide, yeast / zinc fermentation product, nicotinamide, lactobacillus / soy milk fermentation product filtrate, PPG-13-decyltetradecyl alcohol polyether-24, PPG-70 polyglycerol-10 ether, African neem bark extract, Anemarrhena asphodeloides root extract, Ginseng root extract, Ginger root extract, Polygonum multiflorum root extract, moisturizer, emollient and other raw materials with functions of preventing hair loss and promoting hair growth, controlling oil, etc., to prepare a composition with excellent effects of preventing hair loss and promoting hair growth, controlling oil, high stability and the ability to remain stable in a high temperature environment.

[0026] The composition of the present invention can promote the darkening of the skin area of ​​hairless mice by 150.3±18.4 hours, and promote the hair growth in the hairless area by 242.4±22.1 hours; the composition of the present invention can promote the darkening of the skin area of ​​hairless mice by 73.4 hours in advance, and promote the hair growth in the hairless area by 71.7 hours; the composition of the present invention has excellent effects in promoting hair growth and inhibiting hair loss.

[0027] The zeta potential of the dilution of the composition of the present invention diluted 40 times reaches -49.75 mV; after the dilution is placed at 50° C. for 2 days, the zeta potential reaches -43.67 mV; the composition of the present invention has good stability and a good shelf life.

[0028] The ingredients used in the present invention, such as aminopyrimidine oxide, PPG-70 polyglycerol-10 ether, PPG-13-decyltetradecyl alcohol polyether-24, African neem bark extract, Anemarrhena root extract, Ginseng root extract, etc., have a promoting effect on the combined anti-hair loss effect.

[0029] The present invention uses aminopyrimidine oxide and African neem bark extract to promote the anti-hair loss effect of the composition; and when the ratio is 1:0.6-1.2, the effect produced is better.

[0030] The PPG-70 polyglycerol-10 ether and PPG-13-decyltetradecyl alcohol polyether-24 in the present invention affect the anti-hair loss and stability of the composition. The combination of the two can synergistically promote the delivery and absorption of the active ingredients of the product, giving the composition excellent anti-hair loss and stabilization effects; the composition prepared with a ratio of the two of 1.2-2.5:1 has better anti-hair loss and stability.

[0031] The composition of the invention has excellent effects, is simple to prepare, and has good application prospects; and the product has good stability and can be stored for a long time. DETAILED DESCRIPTION

[0032] The present invention will be described below in conjunction with specific embodiments, and various effects of the present invention will be more clearly presented. It should be understood by those skilled in the art that these specific embodiments are used to illustrate the present invention, rather than to limit the present invention.

[0033] The raw material information used in the present invention is as follows:

[0034] Diaminopyrimidine oxide: molecular formula C4H6N4O, Zhuhai Bairui Pharmaceutical Technology Co., Ltd. Yeast / zinc fermentation product: Angel Yeast Co., Ltd. Nicotinamide: Jiangxi Haiwen Biotechnology Co., Ltd. Lactobacillus / soymilk fermentation product filtrate: Xianting Guangzhou Trading Co., Ltd. Sodium hyaluronate: Hybloom TM Low molecular weight sodium hyaluronate (HA-TLM 3-5S), Bloomage Biotech Co., Ltd.

[0035] African neem bark extract: The African neem bark was crushed to a particle size of less than 100 mesh, added with 20 times the mass concentration of 40% ethanol aqueous solution, heated to 60°C, stirred at 60rpm for 4 hours, then cooled to room temperature, and filtered through a 0.5 micron pore size filter membrane. The filtrate was ultrafiltered using an ultrafiltration membrane with a molecular weight cutoff of 1000Da, and the ultrafiltrate was freeze-dried at -40°C to a water content of 2.78wt%.

[0036] Anemarrhena root extract: The Anemarrhena root is crushed to a particle size of less than 120 mesh, 25 weight percent water is added, boiled, and then heated at 85°C for 5 hours, water is added every 30 minutes to the initial volume of water added, and the heating process is accompanied by stirring at 50 rpm; then cooled to room temperature, filtered through a 0.5 micron pore size filter membrane, and then the filtrate is ultrafiltered using an ultrafiltration membrane with a molecular weight cutoff of 800Da, and the ultrafiltrate is freeze-dried at -35°C to a water content of 2.91wt%.

[0037] The preparation methods of ginseng root extract, ginger root extract and Polygonum multiflorum root extract are as follows: the plant raw materials (ginseng root, ginger root, Polygonum multiflorum root) are crushed to less than 150 mesh, 22 times the mass of 55wt% ethanol aqueous solution are added, stirred at 58°C and 65rpm for 5.2 hours, then cooled to room temperature, filtered through a 0.5 micron filter membrane to obtain a crude filtrate, and then the crude filtrate is ultrafiltered through an ultrafiltration membrane with a molecular weight cutoff of 1000Da, and the ultrafiltrate is freeze-dried at -40°C to a water content of 3.14wt%.

[0038] The specific information of the raw materials and dosage of the composition is shown in Table 1-2.

[0039] Table 1: Composition of raw materials

[0040]

[0041]

[0042]

[0043] Table 2: Composition of raw materials

[0044]

[0045]

[0046]

[0047] The preparation method of the above-mentioned composition is as follows: placing a moisturizer, an emollient, water, PPG-13-decyltetradecyl alcohol polyether-24, and PPG-70 polyglycerol-10 ether in a container, heating to 62° C. and stirring at 800 rpm for 0.5 hour; cooling to 45° C., adding the remaining raw materials, continuing to stir for 0.4 hour, cooling to room temperature, standing for 2 hours, and sterilizing to obtain the composition.

[0048] The above compositions were subjected to performance tests.

[0049] 1. Anti-hair loss effect test

[0050] A mouse hair loss model was established, and then the drug was administered and the time for the skin in the hair loss area to turn from pink to black and the time for hair to grow was tested. The time value of the test was used to measure the anti-hair loss effect of the composition. Among them, the shorter the time, the better the effect of promoting hair growth and inhibiting hair loss.

[0051] The specific testing process is as follows:

[0052] Step 1: Select 24±2g healthy C57BL / 6 male mice and feed them adaptively for 3 days; anesthetize the mice and then depilate the same 2.5cm long and wide area on the back. On the second day of depilation, mice with smooth skin and no wounds in the depilated area were divided into blank control group, model group, positive drug control group and combination groups 1-12, a total of 15 groups, 10 mice in each group.

[0053] Step 2: The mice in the blank control group were not treated in any way, and the mice in the other groups were coated with 125 μL of 0.052 wt% testosterone solution on the hair removal area once a day for 15 consecutive days; the mice in each group were fed and given normal drinking water.

[0054] Step 3: Two hours after the last application of testosterone solution, the drug application operation was performed; the blank control group and the model group did not receive any treatment; the positive drug control group applied 120 μL of 2.4% finasteride solution to the hair removal area; the combination group used 120 μL of the corresponding composition 1-12 of each group to apply to the hair removal area; the application was performed once a day for 15 consecutive days; the mice in each group were fed and given drinking water normally.

[0055] Step 4: After the application and administration, observe the skin and hair growth of the depilatory area of ​​each group of mice, and record the time T1 when the skin color of the depilatory area of ​​each mouse in each group changes from pink to black and the time T2 when hair starts to grow. The specific test results are shown in Table 3.

[0056] Table 3: T1 and T2 of each group

[0057]

[0058]

[0059] According to the test data in Table 3, the advance time values ​​of T1 and T2 of each group compared with the model group were calculated, and the difference in experimental effect between the groups was measured. The results are shown in Table 4.

[0060] Table 4: △T1 and △T2 of each group compared with the model group

[0061]

[0062]

[0063] 2. Stability test

[0064] The above composition was diluted 40 times with ultrapure water, stirred at 30° C. and 400 rpm for half an hour, cooled to room temperature, and tested for Zeta potential. The results are shown in Table 5.

[0065] Table 5: Zeta potential of dilutions

[0066] test Zeta potential / mV Composition 1 -49.75 Composition 2 -48.37 Composition 3 -20.17 Composition 9 -43.64 Composition 10 -45.97 Composition 11 -48.01 Composition 12 -46.53

[0067] After the above-tested dilutions were placed at 50° C. for 2 days, the zeta potential of each dilution was tested again. The test results are shown in Table 6.

[0068] Table 6: Zeta potential at 50°C for 7 days

[0069] test Zeta potential / mV Composition 1 -43.67 Composition 2 -41.28 Composition 3 -12.37 Composition 9 -36.21 Composition 10 -38.48 Composition 11 -40.81 Composition 12 -39.52

[0070] According to the test results in Tables 3-6, the composition of the present invention has excellent anti-hair loss effect and excellent stability and can still exist stably in a high temperature environment.

[0071] The test showed that the composition of the present invention can promote the darkening of the skin area of ​​hair-removing mice by 150.3±18.4 hours, and promote the growth of hair in the hair-removing area by 242.4±22.1 hours; the composition of the present invention can promote the darkening of the skin area of ​​hair-removing mice by 73.4 hours in advance, and promote the growth of hair in the hair-removing area by 71.7 hours; the composition of the present invention has excellent effects in promoting hair growth and inhibiting hair loss.

[0072] The zeta potential of the dilution of the composition of the present invention diluted 40 times reaches -49.75 mV; after the dilution is placed at 50° C. for 2 days, the zeta potential reaches -43.67 mV; the composition of the present invention has good stability and a good shelf life.

[0073] The test results of compositions 1, 3 and 8 show that the ingredients used in the present invention, such as aminopyrimidine oxide, PPG-70 polyglycerol-10 ether, PPG-13-decyltetradecyl alcohol polyether-24, neem bark extract, Anemarrhena root extract, and Panax ginseng root extract, have a promoting effect on the anti-hair loss effect of the combination.

[0074] The test results of compositions 1, 4-7 show that the combination of aminopyrimidine oxide and African neem bark extract in the present invention has the effect of promoting and enhancing the anti-hair loss effect of the composition; and when the ratio is 1:0.6-1.2, the effect is better.

[0075] Through the test of compositions 1, 9-12, it can be seen that PPG-70 polyglycerol-10 ether and PPG-13-decyltetradecyl alcohol polyether-24 affect the anti-hair loss and stability of the composition. The combination of the two can synergistically promote the delivery and absorption of the active ingredients of the product, giving the composition excellent anti-hair loss and stabilization effects; the composition prepared with a ratio of the two in 1.2-2.5:1 has better anti-hair loss and stability.

[0076] The composition of the invention has excellent effects, is simple to prepare, and has good application prospects; and the product has good stability and can be stored for a long time.

[0077] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A composition having the functions of preventing hair loss, promoting hair growth and controlling oil, characterized in that: The raw materials include diaminopyrimidine oxide, yeast / zinc fermentation product, niacinamide, and lactobacillus / soy milk fermentation product filtrate.

2. The composition according to claim 1, characterized in that Also included are PPG-13-decyltetradeceth-24 and PPG-70 polyglyceryl-10 ether.

3. The composition according to claim 1, characterized in that Also included are African neem bark extract, Anemarrhena asphodeloides root extract, Panax ginseng root extract, Ginger root extract, and Polygonum multiflorum root extract.

4. The composition according to claim 1, characterized in that It also includes water, moisturizers, and emollients.

5. The composition according to claim 1, characterized in that According to the mass percentage, the raw materials include 0.05-1.2% diaminopyrimidine oxide, 0.05-2% yeast / zinc fermentation product, 0.05-0.5% niacinamide, 0.05-1.5% lactobacillus / soy milk fermentation product filtrate, 1-5% PPG-13-decyltetradecyl alcohol polyether-24, 1-3% PPG-70 polyglycerol-10 ether, 0.05-2% African neem bark extract, 0.05-1.5% Anemarrhena asphodeloides root extract, 0.05-1.5% ginseng root extract, 0.05-1.5% ginger root extract, 0.05-1.5% Polygonum multiflorum root extract, 4-12% moisturizer, 4-10% emollient and the balance water.

6. The composition according to claim 5, characterized in that The mass ratio of PPG-13-decyltetradecyl alcohol polyether-24 and PPG-70 polyglycerol-10 ether is 1.2-2.5:

1.

7. The composition according to claim 5, characterized in that The mass ratio of diaminopyrimidine oxide to the neem bark extract is 1:0.6-1.

2.

8. The composition according to claim 5, characterized in that It also includes at least one of a preservative, a pigment, a flavor, a chelating agent, and a pH adjuster.

9. A method for preparing the composition according to any one of claims 1 to 8, characterized in that: The process comprises mixing raw materials to obtain the composition.

10. Use of the composition according to any one of claims 1 to 8 in the preparation of cosmetics or hair pharmaceutical preparations.

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