Cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide, piroctone olamine, niacinamide, and at least 1% by weight of a particular hydroxylated compound

Abstract

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, niacinamide, and at least 1% by weight of a particular hydroxylated compound. The invention also relates to a cosmetic treatment method for human keratinous materials such as skin, particularly scalp, hair, and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention. The present invention further relates to the use of said cosmetic composition to treat hair loss and / or promote the regrowth of keratin fibers.

Description

Title of the invention: Cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide, piroctone olamine, niacinamide, and at least 1% by weight of a particular hydroxylated compound

[0001] The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, niacinamide, and at least 1% by weight of a particular hydroxylated compound.

[0002] The invention also relates to a cosmetic treatment method for human keratinous materials such as skin, in particular scalp, hair and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention.

[0003] The present invention also relates to the use of said cosmetic composition to treat hair loss, and / or promote the regrowth of keratin fibers.

[0004] The present invention relates to the field of cosmetic treatment of human keratinous materials, in particular human keratinous fibers, such as human hair, eyebrows, eyelashes and / or body hair, including beard, mustache and pubic hair, and skin, including the scalp and areas of skin, particularly alopecic or non-alopecic areas, preferably alopecic, covered with keratinous fibers as mentioned above. More particularly, the invention relates to the cosmetic treatment of human hair and / or eyelashes and / or skin, preferably hair and / or scalp.

[0005] Hair growth and renewal in humans are primarily determined by the activity of hair follicles and their dermo-epidermal environment. Their activity is cyclical and essentially comprises three phases: the anagen phase, the catagen phase, and the telogen phase.

[0006] The anagen phase (corresponding to the active or growth phase), which lasts several years and during which the hair lengthens, is followed by a very short and transient catagen phase lasting a few weeks. During this phase, the hair undergoes a transformation, the follicle atrophies, and its dermal implantation appears increasingly higher.

[0007] The terminal phase, which lasts a few months, corresponds to a resting phase, called the telogen phase. At the end of this resting period, the hairs fall out and make way for new hair follicles in the anagen phase so that another hair cycle can begin.

[0008] Hair is therefore constantly renewing itself, and of the approximately 150,000 hairs in a head of hair, at any given moment, about 10% of them are at rest and will therefore be replaced in a few months.

[0009] Alopecia refers to the accelerated loss of hair, eyelashes, eyebrows, and / or body hair. It generally occurs in genetically predisposed individuals and primarily affects men. This is known as androgenetic alopecia, androgenic alopecia, or androgenetic alopecia.

[0010] Alopecia is essentially due to a disruption of hair renewal, which initially leads to an acceleration of the cycle frequency at the expense of hair quality and then its quantity. This results in a progressive thinning of the hair through the regression of so-called "terminal" hairs to the vellus stage. Certain areas are preferentially affected; in men, in particular, the temporal or frontal hairline and the upper part of the occipital region, while in women, diffuse alopecia of the vertex is more common.

[0011] Other causes can lead to significant hair loss, whether temporary or permanent. These include hair loss and alteration after pregnancy (or postpartum), during periods of malnutrition or dietary imbalances, or during periods of asthenia or hormonal dysfunction, such as may occur during or after menopause. Hair loss or alteration may also be related to seasonal phenomena.

[0012] Alopecia can also affect eyelashes, eyebrows and / or hair on any part of the human body and can cause aesthetic discomfort in the same way as alopecia affecting one or more areas of the scalp.

[0013] People thus subject to alopecia are increasingly resorting to cosmetic treatments to suppress and / or reduce the effect of alopecia, and in particular to decrease or delay the loss of hair, eyelashes and / or body hair, as well as to induce or stimulate their growth.

[0014] Such treatments generally consist of daily applications to the various alopecic areas of the human body, in particular to the alopecic areas of the scalp, such as the temporal or frontal temples in men, or to the areas of the body without hair, in particular on the face, including the beard, moustache and / or eyebrows, of cosmetic compositions comprising one or more anti-hair loss agents and / or agents capable of promoting regrowth.

[0015] For this purpose, agents capable of reducing the loss and / or promoting the regrowth of keratin fibers can be cited in particular as agents such as minoxidil, finasteride, aminexil or even stemoxydine.

[0016] The duration of these treatments generally varies from several weeks to several months, or even can extend over years, and their long-term effectiveness most often depends on the diligence shown by the user in regularly applying the cosmetic compositions to the areas to be treated, which can be more or less extensive.

[0017] The implementation of treatments capable of reducing hair loss and / or promoting the regrowth of hair, eyelashes and / or body hair may take several weeks before the desired effects can be observed, in particular slowing down alopecia.

[0018] These treatments must be used daily to achieve pronounced effectiveness.

[0019] However, these compositions still too often present numerous drawbacks in use which can have a negative impact on the cosmetic treatment to be followed, potentially leading to a more or less rapid abandonment of the treatment and, consequently, to weak results in terms of limiting, or even suppressing, alopecia.

[0020] Indeed, many formulations include gelling agents to prevent the product from running onto the face, into the eyes, or down the neck. However, the use of gelling agents, particularly with daily use, leads to the aggregation of keratin fibers, resulting in a sticky feeling in the hair that is unacceptable to consumers.

[0021] To improve the effectiveness of these treatments, it may be necessary to increase the quantities of active ingredients, which can lead to difficulties in solubilizing the active ingredients and, during use, the formation of visible powders on the keratin fibers and scalp. This powdery effect is also unacceptable to consumers. Anti-hair loss lotions must be used daily to achieve significant effectiveness. Some consumers wash their hair every day, and in this case, the products previously applied to the scalp are washed away. Most consumers do not wash their hair every day, so the product applied on the second day adds to the product applied on the first day. This is known as a cumulative effect. In the context of repeated application without washing the scalp, the appearance of powder may be present from the first day, and more often on the second day.This appearance of powder results from the precipitation of the solid compounds in the formula during the evaporation of the solvent.

[0022] Consequently, the insufficient usability of these compositions may, in the long run, discourage users from diligently following anti-hair loss and / or regrowth cosmetic treatments, especially since the effectiveness of these treatments is primarily linked to the daily regularity of the application of the compositions described previously on the areas to be treated for several weeks, or even several months.

[0023] In other words, a lack of diligence or premature discontinuation of treatment most often leads to poor results in terms of hair loss prevention and / or regrowth efficacy and, consequently, to dissatisfaction. This reinforces disappointment among consumers who do not have the time to observe the progress and / or long-term efficacy of these treatments.

[0024] There is therefore a real need to overcome the aforementioned drawbacks, particularly by implementing a composition capable of cosmetically and effectively treating the loss of human keratin fibers such as hair, body hair, and / or eyelashes, and / or promoting their regrowth, with improved usability while ensuring, in particular, a satisfactory visual result, notably without a greasy effect or residue. This composition must also allow for repeated application, i.e., allow for daily use of the composition.

[0025] This objective is achieved by the present invention, which relates in particular to a cosmetic composition comprising: i) 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, ii) piroctone olamine, iii) niacinamide, and (iv) at least 1% by weight, relative to the total weight of the composition, of one or more hydroxylated compounds having a melting point below 25°C at atmospheric pressure (1.013.105 Pa) (e.g. they are liquid at 25°C and atmospheric pressure) and a boiling point greater than or equal to 170°C, preferably chosen from hydroxylated compounds consisting of a C2-C8 hydrocarbon chain possibly interrupted by an oxygen atom and comprising 1 to 2 free hydroxylated groups (-OH) on different carbon atoms.

[0026] The cosmetic composition according to the invention has improved performance qualities by making it possible to avoid the powdery effect and / or aggregation of keratin fibers, in particular in the context of repeated application required by frequent use.

[0027] The cosmetic composition according to the invention also provides complete satisfaction in terms of anti-hair loss efficacy and / or regrowth of keratin fibers. Furthermore, it has a beneficial effect on increasing the diameter of keratin fibers and strengthening them against breakage.

[0028] Furthermore, the composition according to the invention makes it possible to give the keratin fibers good cosmetic properties, in particular conditioning properties, especially in In terms of suppleness, suppleness, and smoothness to the touch. It also allows for easier detangling.

[0029] The invention also relates to a cosmetic treatment method for human keratinous materials such as skin, in particular scalp, hair and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention.

[0030] The present invention also relates to the use of said cosmetic composition to treat hair loss, and / or promote the regrowth of keratin fibers.

[0031] The present invention also relates to the use of said cosmetic composition to increase the diameter of keratin fibers and / or strengthen keratin fibers against breakage.

[0032] Other objects, features, aspects and advantages of the invention will become even clearer upon reading the description and example that follows.

[0033] In what follows, and unless otherwise indicated, the bounds of a range of values ​​are included in that range, in particular in the expressions "between" and "ranging from ... to ...".

[0034] Furthermore, the expression "at least one" used in this description is equivalent to the expression "one or more".

[0035] i) 2A-diaminopyrimidine-3-N-oxide The cosmetic composition according to the invention comprises 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates.

[0036] The 2,4-diaminopyrimidine-3-N-oxide has the following formula: O

[0037] Among the usable organic or mineral acid salts, hydrochlorides, sulfates, citrates, and acetates may be mentioned in particular. Monohydrate may be mentioned in particular as a hydrate.

[0038] Preferably, the unsalted compound is used in the form of monohydrate.

[0039] Preferably, the total content of 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates ranges from 0.05 to 8% by weight, better from 0.1 to 5%, even better from 0.2 to 4%, then from 0.5 to 3%, and preferably from 1 to 2% by weight, relative to the total weight of the composition.

[0040] Preferably, the content of 2,4-diaminopyrimidine-3-N-oxide and / or one of its hydrates, in particular monohydrate, ranges from 0.05 to 8% by weight, better from 0.1 to 5%, even better from 0.2 to 4%, from 0.5 to 3% and preferably from 1 to 2% by weight, relative to the total weight of the composition.

[0041] ii) Piroctone Olamine The cosmetic composition according to the invention also includes piroctone olamine.

[0042] Piroctone olamine is a monoethanolamine salt of l-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(lH)-pyridinone.

[0043] Preferably, the total piroctone olamine content is from 0.05 to 2% by weight, better from 0.1 to 1%, preferably from 0.1 to 0.5% by weight, relative to the total weight of the composition.

[0044] iii) Niacinamide The cosmetic composition according to the invention further comprises niacinamide (3-pyridinecarboxamide).

[0045] Niacinamide is also known as nicotinamide.

[0046] Preferably, the total niacinamide content ranges from 1 to 5% by weight, preferably 2 to 5% by weight, relative to the total weight of the composition.

[0047] iv) Hydroxylated compounds The cosmetic composition according to the invention further comprises one or more hydroxylated compounds iv) having a melting point below 25°C at atmospheric pressure (1.013.105 Pa) (e.g. they are liquid at 25°C and atmospheric pressure) and a boiling point greater than or equal to 170°C.

[0048] Preferably, said hydroxylated compounds iv) consist of a C2-C8 hydrocarbon chain optionally interrupted by an oxygen atom and comprising 1 to 2 free hydroxylated groups (-OH) carried by different carbon atoms.

[0049] These compounds can be cyclic or acyclic, linear or branched, saturated or unsaturated.

[0050] Preferably, the hydroxylated compound(s) iv) are chosen from linear C2-C8 diols, preferably C2-C6, or aromatic monoalcohols in C6-C8, preferably C7-C8, and mixtures thereof. More preferably, the hydroxylated compound(s) iv) are chosen from linear C2-C8 diols, preferably C2-C6.

[0051] In particular, we can mention propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, propane-1,3 diol, benzyl alcohol, phenethyl alcohol (phenylethyl alcohol), dipropylene glycol, and more preferably the hydroxylated compound iv) is propylene glycol.

[0052] The total content of hydroxylated compounds iv) in the composition is greater than or equal to 1% by weight, relative to the total weight of the composition, preferably greater than or equal to 1.5% by weight, relative to the total weight of the composition.

[0053] Preferably, the total content of hydroxylated compounds iv) is from 1 to 15% by weight, better from 1.5 to 10%, more preferably from 2 to 8% by weight, more preferably still from 2.1 to 6% by weight, better 2.2 to 5%, even better 2.3 to 4% by weight, relative to the total weight of the composition.

[0054] Preferably, the total content of hydroxylated compounds iv) selected from linear C2-C8 diols is greater than or equal to 1% by weight, better from 1 to 15%, preferably from 1.5 to 10% by weight, more preferably from 2 to 8% by weight, more preferably still from 2.1 to 6% by weight, better from 2.2 to 5% by weight, even better from 2.3 to 4% by weight, relative to the total weight of the composition.

[0055] Preferably, the total propylene glycol content is greater than or equal to 1% by weight, better from 1 to 15%, preferably from 1.5 to 10% by weight, more preferably from 2 to 8% by weight, more preferably still from 2.1 to 6% by weight, better from 2.2 to 5% by weight, even better from 2.3 to 4% by weight, relative to the total weight of the composition.

[0056] v) Ginger root extract The cosmetic composition according to the invention may optionally further include a ginger root extract (INCI name: Zingiber officinale root extract).

[0057] Ginger root extract may be in the form of a ground product, powder or liquid, preferably in liquid form.

[0058] Ginger root extract can in particular be obtained by supercritical CO2 extraction from fragments of ginger root, for example from ginger root powder.

[0059] Preferably, the composition according to the invention comprises a ginger root extract

[0060] When present in the composition according to the invention, the total content of ginger root extract is preferably from 0.02 to 0.2% by weight, more preferably from 0.05 to 0.2% by weight, relative to the total weight of the composition.

[0061] vi) Solvents The composition according to the invention may optionally include one or more organic solvents different from the hydroxylated compounds iv) previously described.

[0062] These organic solvents are preferably chosen from monoalcohols in Cl-C5, preferably in C2-C4. Ethanol is particularly preferred.

[0063] Preferably, the composition comprises one or more organic solvents different from the hydroxylated compounds iv) previously described, preferably one or more C2-C4 monoalcohols, better ethanol.

[0064] When present, the total content of organic solvents other than the hydroxylated compounds iv) is preferably from 1 to 60% by weight, preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, better from 20 to 35% by weight relative to the total weight of the composition.

[0065] When the composition includes ethanol, the ethanol content is preferably from 1 to 60% by weight, preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, better from 20 to 35% by weight relative to the total weight of the composition.

[0066] The composition is preferably aqueous, the water content being able to range from 10 to 90% by weight, preferably from 20 to 80% by weight, preferably from 40 to 70% by weight relative to the total weight of the composition.

[0067] vii) Thickening polymers The composition according to the invention may optionally include one or more thickening polymers.

[0068] By "thickening polymer", according to the present invention, means polymers which, by their presence at a concentration of 0.05% by weight, increase the viscosity of the cosmetic compositions in which they are introduced by at least 20 cps (20 mPa.s), preferably by at least 50 cps (50 mPa.s), at room temperature (25°C), at atmospheric pressure and at a shear rate of 1s (the viscosity can be measured using a cone / plate viscometer, Haake R600 rheometer or similar).

[0069] The thickening polymer(s) usable in the process according to the invention are preferably chosen from non-associative thickening polymers with sugar motifs, non-associative thickening polymers without sugar motifs, associative thickening polymers, and mixtures thereof.

[0070] By "sugar motif", for the purposes of the present invention, means an oxygenated hydrocarbon compound which has several alcohol functions, with or without aldehyde or ketone functions, and which comprises at least 4 carbon atoms.

[0071] The sugar motifs may optionally be modified by substitution, and / or by oxidation and / or by dehydration.

[0072] The sugar motifs of the thickening polymers are preferably derived from the following sugars: glucose; galactose; arabinose; rhamnose; mannose; xylose; fucose; anhydrogalactose; galacturonic acid; glucuronic acid; mannuronic acid; galactose sulfate; anhydrogalactose sulfate and fructose.

[0073] According to the invention, sugar-patterned polymers are also called polysaccharides.

[0074] Examples of non-associative thickening polymers with sugar motifs include native gums such as:

[0075] a) exudates from trees or shrubs, including: - gum arabic (branched polymer of galactose, arabinose, rhamnose and glucuronic acid); - Ghatti gum (polymer derived from arabinose, galactose, mannose, xylose and glucuronic acid); - karaya gum (polymer derived from galacturonic acid, galactose, rhamnose and glucuronic acid); - tragacanth gum (or tragacanth) (polymer of galacturonic acid, galactose, fucose, xylose and arabinose);

[0076] b) gums derived from algae, of which: - agar (polymer derived from galactose and anhydrogalactose); - alginates (polymers of mannuronic acid and glucuronic acid); - carrageenans and furcelleranes (polymers of galactose sulfate and anhydrogalactose sulfate);

[0077] c) gums from seeds or tubers of which: - guar gum (polymer of mannose and galactose); - carob gum (polymer of mannose and galactose); - fenugreek gum (polymer of mannose and galactose); - tamarind gum (polymer of galactose, xylose and glucose); - konjac gum (polymer of glucose and mannose);

[0078] d) microbial gums, of which: - xanthan gum (polymer of glucose, mannose acetate, mannose / pyruvic acid and glucuronic acid); - gellan gum (polymer of partially acylated glucose, rhamnose and glucuronic acid); - scleroglucan gum (glucose polymer);

[0079] e) plant extracts including: - cellulose (polymer of glucose); - starch (polymer of glucose) and - Inulin.

[0080] These polymers can be modified by physical or chemical means. Temperature can be used as an example of a physical treatment.

[0081] Examples of chemical treatments include esterification, etherification, amidation, and oxidation reactions. These treatments lead to polymers that can be, in particular, non-ionic, anionic, or amphoteric.

[0082] Preferably, these chemical or physical treatments are applied to guar gums, locust bean gums, starches and celluloses.

[0083] The non-ionic guar gums usable according to the invention can be modified by (poly)hydroxylakyl groups in Ci-C6.

[0084] Among the (poly)hydroxyalkyl groups in Ci-C6, we can mention by way of example, the hydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups.

[0085] These guar gums are well known from the prior art and can, for example, be prepared by reacting corresponding alkene oxides such as, for example, propylene oxides with guar gum in order to obtain a guar gum modified by hydroxypropyl groups.

[0086] The degree of hydroxyalkylation varies preferably from 0.4 to 1.2 and corresponds to the number of alkylene oxide molecules consumed by the number of free hydroxyl functions present on the guar gum.

[0087] Such non-ionic guar gums possibly modified by hydroxyalkyl groups are for example sold under the trade names JAGUAR HP8, JAGUAR HP60 and JAGUAR HP120 by the company RHODIA CHIMIE.

[0088] The starch molecules usable in the present invention may have cereals or tubers as their botanical origin. Thus, the starches are, for example, chosen from corn, rice, cassava, barley, potato, wheat, sorghum, and pea starches.

[0089] Starches can be modified chemically or physically: in particular by one or more of the following reactions: pregelatinization, oxidation, crosslinking, esterification, etherification, amidification, heat treatments.

[0090] Preferably, distarch phosphates or compounds rich in distarch phosphate will be used, such as the product offered under the references PREJEL VA-70-T AGGL (gelatinized hydroxypropyl cassava distarch phosphate) or PREJEL TK1 (gelatinized cassava distarch phosphate) or PREJEL 200 (gelatinized acetylated cassava distarch phosphate) by the AVEBE Company or STRUCTURE ZEA of NATIONAL STARCH (gelatinized maize distarch phosphate).

[0091] According to the invention, amphoteric starches can also be used; these amphoteric starches comprise one or more anionic groups and one or more cationic groups. The anionic and cationic groups may be linked to the same reactive site of the starch molecule or to different reactive sites; preferably, they are linked to the same reactive site. The anionic groups may be of the carboxylic, phosphate, or sulfate type, and preferably carboxylic. The cationic groups may be of the primary, secondary, tertiary, or quaternary amine type.

[0092] Starch molecules can be derived from all plant sources of starch, such as, in particular, maize, potato, oats, rice, tapioca, sorghum, Barley or wheat. Hydrolysates of the starches mentioned above can also be used. The starch is preferably derived from potatoes.

[0093] The non-associative thickening polymers of the invention may be cellulosic polymers not comprising a Cio-C3o fatty chain in their structure.

[0094] By "cellulosic" polymer, according to the invention, any polysaccharide compound having in its structure chains of glucose residues joined by [3-1,4] bonds; in addition to unsubstituted celluloses, cellulose derivatives can be anionic, cationic, amphoteric or non-ionic.

[0095] Thus, the cellulosic polymers usable according to the invention can be chosen from unsubstituted celluloses including in microcrystalline form and cellulose ethers.

[0096] Among these cellulosic polymers, we distinguish cellulose ethers, cellulose esters and cellulose ether esters.

[0097] Among cellulose esters are inorganic cellulose esters (cellulose nitrates, sulfates, or phosphates, etc.), organic cellulose esters (cellulose monoacetates, triacetates, amidopropionates, acetatebutyrates, acetatepropionates, or acetatetrimellitates, etc.), and mixed organic / inorganic cellulose esters such as cellulose acetatebutyrates and acetatepropionates. Examples of cellulose ether esters include hydroxypropylmethylcellulose phthalates and ethylcellulose sulfates.

[0098] Among non-ionic cellulose ethers without a fat chain in Ci0-C30 i.e. “non-associative”, we can cite (Ci-C4)alkylcelluloses such as methylcelluloses and ethylcelluloses (for example Ethocel standard 100 Premium from DOW CHEMICAL); (poly)hydroxy(Ci-C4)alkylcelluloses such as hydroxymethylcelluloses, hydroxyethylcelluloses (for example Natrosol 250 HHR offered by AQUALON) and hydroxypropylcelluloses (for example Klucel EF from AQUALON); mixed celluloses (poly)hydroxy(Ci-C4)alkyl-(Ci-C4)alkylcelluloses such as hydroxypropyl-methylcelluloses (for example Methocel E4M from DOW CHEMICAL), hydroxyethyl-methylcelluloses, hydroxyethyl-ethylcelluloses (for example Bermocoll E 481 FQ from AKZO NOBEL) and hydroxybutyl-methylcelluloses.

[0099] Among the anionic cellulose ethers without a fat chain, we can mention (poly)carboxy(Ci-C4)alkylcelluloses and their salts. By way of example, we can mention carboxymethylcelluloses, carboxymethylmethylcelluloses (for example Blanose 7M from the company AQUALON) and carboxymethylhydroxyethylcelluloses and their sodium salts.

[0100] Among cationic cellulose ethers without a fat chain, cationic cellulose derivatives such as cellulose copolymers or cellulose derivatives grafted with a water-soluble quaternary ammonium monomer, and described in particular in US patent 4,131,576, include (poly)hydroxy(CrC4)alkyl celluloses, such as hydroxymethyl-, hydroxyethyl-, or hydroxypropyl celluloses grafted in particular with a salt of methacryloylethyl trimethylammonium, methacrylmidopropyl trimethylammonium, or dimethyl-diallylammonium. The marketed products meeting this definition are more specifically those sold under the names "Celquat® L 200" and "Celquat® H 100" by National Starch Company.

[0101] Among the non-associative thickening polymers without sugar motifs that can be used according to the invention, we can mention crosslinked acrylic or methacrylic acid homopolymers or copolymers, crosslinked 2-acrylamido-2-methylpropanesulfonic acid homopolymers and their crosslinked acrylamide copolymers, ammonium acrylate homopolymers or ammonium acrylate and acrylamide copolymers alone or in mixtures.

[0102] A first family of suitable non-associative thickening polymers is represented by crosslinked acrylic acid homopolymers.

[0103] Among homopolymers of this type, we can cite those crosslinked by an allylic ether of an alcohol from the sugar series, such as for example the products sold under the names CARBOPOLS 980, 981, 954, 2984 and 5984 by the company NOVEON or the products sold under the names SYNTHALEN M and SYNTHALEN K by the company 3 VS A. These polymers have the INCI name Carbomer.

[0104] Non-associative thickening polymers can also be crosslinked (meth)acrylic acid copolymers such as the polymer sold under the name AQUA SF1 by the company NOVEON.

[0105] Non-associative thickening polymers can be selected from crosslinked homopolymers of 2-acrylamido-2-methylpropane sulfonic acid and their crosslinked acrylamide copolymers.

[0106] Among the crosslinked copolymers of 2-acrylamido-2-methylpropanesulfonic acid and partially or totally neutralized acrylamide, particular mention may be made of the product described in Example 1 of document EP 503 853 and reference may be made to this document for information relating to these polymers.

[0107] The composition according to the invention may likewise include, as non-associative thickening polymers, ammonium acrylate homopolymers or ammonium acrylate and acrylamide copolymers.

[0108] Examples of ammonium acrylate homopolymers include the product sold under the name MICROS AP PAS 5193 by HOECHST. Examples of ammonium acrylate and acrylamide copolymers include the product sold under the name BOZEPOL C NOUVEAU and the product PAS 5193, both sold by HOECHST. Reference may be made, in particular, to documents FR 2 416 723, US 2798053, and US 2923692 for the description and preparation of such compounds.

[0109] Cationic thickening polymers of the acrylic type can also be used.

[0110] Among thickening polymers, we can also mention associative polymers well known to those skilled in the art and in particular of non-ionic, anionic, cationic or amphoteric nature, preferably anionic.

[0111] It is recalled that "associative polymers" are polymers capable, in an aqueous medium, of reversibly associating with each other or with other molecules.

[0112] Their chemical structure includes more particularly at least one hydrophilic zone and at least one hydrophobic zone.

[0113] By "hydrophobic group" is meant a radical or hydrocarbon chain polymer, saturated or unsaturated, linear or branched, comprising at least 10 carbon atoms, preferably from 10 to 30 carbon atoms, in particular from 12 to 30 carbon atoms and more preferably from 18 to 30 carbon atoms.

[0114] Preferably, the hydrocarbon group is derived from a monofunctional compound. For example, the hydrophobic group may be derived from a fatty alcohol such as stearyl alcohol, dodecyl alcohol, or decyl alcohol. It may also refer to a hydrocarbon polymer such as, for example, polybutadiene.

[0115] Among anionic-type associative polymers, the following may be mentioned:

[0116] - (a) those comprising at least one hydrophilic motif, and at least one ether motif of fatty chain allyl, more particularly those whose hydrophilic motif is made up of an unsaturated ethylenic anionic monomer, more particularly still of a vinylic carboxylic acid and especially of an acrylic acid or a methacrylic acid or mixtures thereof.

[0117] Among these anionic associative polymers, polymers formed from 20 to 60% by weight of acrylic acid and / or methacrylic acid, 5 to 60% by weight of lower alkyl (meth)acrylates, 2 to 50% by weight of fatty chain allyl ether, and 0 to 1% by weight of a crosslinking agent which is a well-known copolymerizable unsaturated polyethylene monomer, such as diallyl phthalate, allyl (meth)acrylate, divinylbenzene, (poly)ethylene glycol dimethacrylate, and methylene-bis-acrylamide.

[0118] Among these, crosslinked terpolymers of methacrylic acid, ethyl acrylate, polyethylene glycol (10 OE) ether are particularly preferred. stearyl alcohol (Steareth 10), in particular those sold by the company CIBA under the names SALCARE SC80® and SALCARE SC90® which are aqueous emulsions with 30% of a crosslinked terpolymer of methacrylic acid, ethyl acrylate and steareth-10-allyl ether (40 / 50 / 10).

[0119] - (b) those comprising i) at least one hydrophilic motif of the carboxylic acid type unsaturated olefinic, and ii) at least one hydrophobic motif of the alkyl ester type of unsaturated carboxylic acid.

[0120] Alkyl esters (C10-C30) of unsaturated carboxylic acids useful to the invention include, for example, lauryl acrylate, stearyl acrylate, decyl acrylate, isodecyl acrylate, dodecyl acrylate, and the corresponding methacrylates, lauryl methacrylate, stearyl methacrylate, decyl methacrylate, isodecyl methacrylate, and dodecyl methacrylate.

[0121] Anionic polymers of this type are described and prepared, for example, according to US patents 3,915,921 and 4,509,949.

[0122] Among this type of anionic associative polymers, we will use more particularly those consisting of 60 to 95% by weight of acrylic acid (hydrophilic motif), 4 to 40% by weight of alkyl acrylate in C10-C3O (hydrophobic motif), and 0 to 6% by weight of polymerizable crosslinking monomer, or those consisting of 96 to 98% by weight of acrylic acid (hydrophilic motif), 1 to 4% by weight of alkyl acrylate in C10-C3O (hydrophobic motif), and 0.1 to 0.6% by weight of polymerizable crosslinking monomer such as those described above.

[0123] Among the aforementioned polymers, the products sold by GOODRICH under the trade names PEMULEN TRI®, PEMULEN TR2®, CARBOPOL 1382®, and even more preferably PEMULEN TRI®, and the product sold by SEPPIC under the name COATEX SX®, are particularly preferred according to the present invention.

[0124] We can also mention the acrylic acid / lauryl methacrylate / vinylpyrrolidone terpolymer marketed under the name Acrylidone LM by the ISP Company.

[0125] - (c) C30-C38 maleic anhydride / α-olefin / alkyl maleate terpolymers such as the product (C3o-C38 maleic anhydride / α-olefin / isopropyl maleate copolymer) sold under the name PERFORMA V 1608® by the company NEWPHASE TECHNOLOGIES.

[0126] - (d) acrylic terpolymers comprising:

[0127] i) approximately 20 to 70% by weight of an unsaturated α,[3-monoethylenic [α],

[0128] ii) approximately 20 to 80% by weight of a non-surfactant α,[3-monoethylenic] unsaturation monomer other than [α],

[0129] iii) approximately 0.5 to 60% by weight of a non-ionic monourethane which is the reaction product of a monohydric surfactant with a monoethylenically unsaturated monoisocyanate,

[0130] such as those described in patent application EP-A-0173109 and more particularly that described in Example 3, namely, a methacrylic acid / methyl acrylate / dimethyl metaisopropenyl benzyl isocyanate terpolymer of ethoxylated behenyl alcohol (40OE) in 25% aqueous dispersion.

[0131] - (e) copolymers comprising among their monomers a carboxylic acid unsaturation α,[3-monoethylenic and an ester of carboxylic acid with unsaturation α,[3-monoethylenic and an oxyalkylated fatty alcohol.

[0132] Preferably these compounds also comprise as a monomer an ester of α,[3-monoethylenic carboxylic acid and Ci-C4 alcohol.

[0133] As an example of this type of compound, one can cite ACULYN 22®, sold by ROHM and HAAS, which is a methacrylic acid / ethyl acrylate / oxyalkylated stearyl methacrylate terpolymer, as well as ACULYN 88, also sold by ROHM and HAAS. Another example is NOVETHIX L-10 POLYMER, sold by LUBRIZOL, with the INCI name ACRYLATES / BEHENETH-25 METHACRYLATE COPOLYMER.

[0134] - (f) Amphiphilic polymers comprising at least one unsaturated monomer ethylenic with a sulfonic group, in free form or partially or totally neutralized and comprising at least one hydrophobic portion. These polymers may be crosslinked or non-crosslinked. They are preferably crosslinked.

[0135] Monomers with ethylenic unsaturation and a sulfonic group are selected in particular from vinylsulfonic acid, styrenesulfonic acid, (meth)acrylamido(Ci-C22)alkylsulfonic acids, N-(Cr C22)alkyl(meth)acrylamido-(Ci-C22)alkylsulfonic acids such as undecyl-acrylamido-methane-sulfonic acid and their partially or totally neutralized forms.

[0136] More preferably, alkylsulfonic (meth)acrylamido(Ci-C22) acids will be used, such as, for example, acrylamido-methane-sulfonic acid, acrylamido-ethane-sulfonic acid, acrylamido-propane-sulfonic acid, 2-acrylamido-2-methylpropane-sulfonic acid, methacrylamido-2-methylpropane-sulfonic acid, 2-acrylamido-n-butane-sulfonic acid, 2-acrylamido-2,4,4-trimethylpentane-sulfonic acid, 2-methacrylamido-dodecyl-sulfonic acid, 2-acrylamido-2,6-dimethyl-3-heptane-sulfonic acid, as well as their partially or totally neutralized forms.

[0137] In particular, 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and its partially or totally neutralized forms will be used.

[0138] Polymers of this family may in particular be selected from statistical amphiphilic AMPS polymers modified by reaction with a C6-C22 n-monoalkylamine or di-n-alkylamine, and such as those described in patent application WO 00 / 31154 (forming an integral part of the content of the description). These polymers may also contain other ethylenically unsaturated hydrophilic monomers selected, for example, from (meth)acrylic acids, their [3]-substituted alkyl derivatives or their esters obtained with monoalcohols or mono- or poly-alkylene glycols, (meth)acrylamides, vinylpyrrolidone, maleic anhydride, itaconic acid or maleic acid or mixtures of these compounds.

[0139] Preferred polymers of this family are chosen from among amphiphilic copolymers of AMPS and at least one hydrophobic monomer with ethylenic unsaturation.

[0140] These same copolymers may further contain one or more ethylenically unsaturated monomers without a fatty chain such as (meth)acrylic acids, their [3]-substituted alkyl derivatives or their esters obtained with monoalcohols or mono- or poly-alkylene glycols, (meth)acrylamides, vinylpyrrolidone, maleic anhydride, itaconic acid or maleic acid or mixtures of these compounds.

[0141] These copolymers are described in particular in patent application EP-A-750899, US patent 5089578 and in the following publications by Yotaro Morishima:

[0142] - “Self-assembly amphiphilic polyelectrolytes and their nanostructures - Chinese Journal of Polymer Science Vol. 18, No. 40, (2000), 323-336. » ;

[0143] - “Miscelle formation of random copolymers of sodium 2-(acrylamido)-2- methylpropanesulfonate and a non-ionic surfactant macromonomer in water as studied by fluorescence and dynamic light scattering - Macromolecules, Vol. 33, No. 10 (2000), 3694-3704”;

[0144] - “Solution properties of miscelle networks formed by non-ionic moieties covalently bound to an polyelectrolyte: known effects on rheological behavior - Langmuir, Vol. 16, No. 12, (2000) 5324-5332”;

[0145] - “Stimuli responsive amphiphilic copolymers of sodium 2-(acrylamido)-2- methylpropanesulfonate and associative macromonomers - Polym. Preprint, Div. Polym. Chem., 40(2), (1999), 220-221”.

[0146] Among these polymers, we can mention:

[0147] - crosslinked or non-crosslinked copolymers, neutralized or not, comprising from 15 to 60% by weight of AMPS patterns and from 40 to 85% by weight of patterns (C8- Ci6)alkyl(meth)acrylamide or (C8-Ci6)alkyl(meth)acrylate motifs relative to the polymer, such as those described in application EP-A750 899;

[0148] - terpolymers comprising 10 to 90% by mole of acrylamide motifs, of 0.1 to 10 mole percent of AMPS motifs and 5 to 80 mole percent of n-(C6-Ci8)alkylacrylamide motifs, such as those described in US patent 5089578.

[0149] We can also mention copolymers of totally neutralized AMPS and dodecyl methacrylate as well as copolymers of uncrosslinked and crosslinked AMPS and n-dodecylmethacrylamide, such as those described in the articles by Morishima cited above.

[0150] Among cationic associative polymers, the following may be mentioned:

[0151] (a) cationic associative polyurethanes;

[0152] (b) the compound marketed by NOVEON under the name AQUA CC and which corresponds to the INCI name POLYACRYLATE-1 CROSSPOLYMER.

[0153] POLYACRYLATE-1 CROSSPOLYMER is the product of the polymerization of a mixture of monomers comprising: - a di(alkyl C1-C4)amino(alkyl Ci-C6) methacrylate, - one or more Ci-C30 alkyl esters of (meth)acrylic acid, - a polyethoxylated Cio-C3o alkyl methacrylate (20-25 moles of ethylene oxide motif), - an allyl polyethylene glycol / polypropylene glycol 30 / 5 ether, - a hydroxy(C2-C6 alkyl) methacrylate, and - ethylene glycol dimethacrylate.

[0154] (c) the (poly)hydroxyethylcelluloses quantified and modified by groups comprising at least one fatty chain, such as alkyl, arylalkyl, alkylaryl groups with at least 8 carbon atoms, or mixtures thereof. The alkyl radicals present in the quaternized celluloses or hydroxyethylcelluloses above preferably have from 8 to 30 carbon atoms. The aryl radicals preferably refer to phenyl, benzyl, naphthyl, or anthryl groups. Examples of quaternized alkylhydroxyethylcelluloses with C8-C30 fatty chains include QUATRISOFT LM 200®, QUATRISOFT LM-X 529-18-A®, QUATRISOFT LM-X 529-18-B® (C12 alkyl) and QUATRISOFT LM-X 529-8® (Ci8 alkyl) sold by AQUALON, CRODACEL QM®, CRODACEL QL® (Ci2 alkyl) and CRODACEL QS® (C[8] alkyl) sold by CRODA, and SOFTCAT SL 100® sold by AQUALON.

[0155] (d) cationic polyvinyllactam polymers.

[0156] Such polymers are described for example in patent application WO-00 / 68282.

[0157] As cationic poly(vinyllactam) polymers according to the invention, the following are used in particular: vinylpyrrolidone / dimethylaminopropylmethacrylamide / dodecyldimethylmethacrylamide tosylate terpolymers, vinylpyrrolidone / dimethylaminopropylmethacrylamide / cocoyldhnethyl-methacrylamide propylammonium tosylate terpolymers, vinylpyrrolidone / dimethylamino-propylmethacrylamide / lauryldimethylmethacrylamide tosylate or chloride terpolymers.

[0158] Amphoteric associative polymers are preferably chosen from those comprising at least one non-cyclic cationic motif. More particularly, those prepared from or comprising 1 to 20 moles % of monomer having a fatty chain, and preferably 1.5 to 15 moles % and more particularly 1.5 to 6 moles %, relative to the total number of moles of monomers, are preferred.

[0159] Amphoteric associative polymers according to the invention are for example described and prepared in patent application WO 9844012.

[0160] Among the amphoteric associative polymers according to the invention, acrylic acid / (meth)acrylamidopropyl trimethyl ammonium / stearyl methacrylate terpolymers are preferred.

[0161] The non-ionic associative polymers usable according to the invention are preferably chosen from:

[0162] (a) copolymers of vinyl pyrrolidone and hydrophobic chain monomers fat, of which we can cite as an example:

[0163] - ANTARON V216® or GANEX V216® products (vinylpyrrolidone copolymer / hexadecene) sold by the company ISP

[0164] - ANTARON V220® or GANEX V220® products (vinylpyrrolidone copolymer / eicosene) sold by the company ISP

[0165] (b) copolymers of methacrylates or alkyl acrylates in C1-C6 and amphiphilic monomers comprising at least one fatty chain such as for example the methyl acrylate / oxyethylenated stearyl acrylate copolymer sold by the company GOLDSCHMIDT under the name ANTIL 208®.

[0166] (c) copolymers of methacrylates or hydrophilic acrylates and monomers hydrophobics comprising at least one fatty chain such as, for example, polyethylene glycol methacrylate / lauryl methacrylate copolymer.

[0167] (d) polyether polyurethanes comprising in their chain, both sequences hydrophilic sequences, most often polyoxyethylenated in nature, and hydrophobic sequences which can be aliphatic chains alone and / or cycloaliphatic chains and / or aromatic chains.

[0168] (e) aminoplast ether backbone polymers having at least one chain oily, such as the PURE THIX® compounds offered by the company SUD-CHEMIE.

[0169] (f) celluloses or their derivatives, modified by groups comprising at minus a fatty chain such as alkyl, arylalkyl, alkylaryl groups or mixtures thereof where the alkyl groups are in C8- and in particular:

[0170] * non-ionic alkylhydroxyethylcelluloses such as NATROSOL products PLUS GRADE 330 CS and POLYSURF 67 (alkyl in Ci6) sold by the company AQUALON

[0171] * non-ionic nonoxynylhydroxyethylcelluloses such as the product AMERCELL HM-1500 sold by the company AMERCHOL;

[0172] * non-ionic alkylcelluloses such as the product BERMOCOLL EHM 100 sold by the company BEROL NOBEL;

[0173] (g) associative guar derivatives such as hydroxypropyl guars modified by a fat chain such as the product ESAFLOR HM 22 (modified by a C22 alkyl chain) sold by the company LAMBERTI; the product MIRACARE XC 95-3 (modified by a C14 alkyl chain) and the product RE 205-146 (modified by a C20 alkyl chain) sold by RHODIA CHIMIE.

[0174] Preferably, the polyurethane polyethers comprise at least two lipophilic hydrocarbon chains, having from 6 to 30 carbon atoms, separated by a hydrophilic sequence. The hydrocarbon chains may be dangling chains or end chains of a hydrophilic sequence. In particular, one or more dangling chains may be provided. Furthermore, the polymer may comprise a hydrocarbon chain at one or both ends of a hydrophilic sequence.

[0175] Polyurethane polyethers can be multi-sequenced, particularly in triblock form. The hydrophobic sequences can be at each end of the chain (e.g., a triblock copolymer with a hydrophilic central sequence) or distributed both at the ends and throughout the chain (e.g., a multi-sequenced copolymer). These same polymers can also be in graft or star form.

[0176] Nonionic fatty-chain polyurethane polyethers can be triblock copolymers in which the hydrophilic sequence is a polyoxyethylenated chain comprising 50 to 1000 oxyethylenated groups. Nonionic polyurethane polyethers have a urethane bond between the hydrophilic sequences, hence the origin of the name.

[0177] By extension, non-ionic fatty chain polyurethane polyethers also include those whose hydrophilic sequences are linked to lipophilic sequences by other chemical bonds.

[0178] As examples of non-ionic fat-chain polyurethane polyethers usable in the invention, Rhéolate 205® with urea function sold by the company RHEOX or Rhéolates® 208, 204 or 212, as well as Acrysol RM 184®, can also be used.

[0179] We can also mention the ELFACOS T210® product with a Ci2-u alkyl chain and the ELFACOS T212® product with a C[8] alkyl chain from AKZO.

[0180] The product DW 1206B® from ROHM & HAAS with C2o alkyl chain and urethane bonding, offered at 20% dry matter in water, can also be used.

[0181] Solutions or dispersions of these polymers can also be used, particularly in water or in hydroalcoholic media. For example, RHEOLATE® 255, RHEOLATE® 278, and RHEOLATE® 244, sold by RHEOX, are examples of such polymers. DW 1206F and DW 1206J, offered by ROHM & HAAS, can also be used.

[0182] Polyurethane polyethers usable according to the invention are in particular those described in the article by G. Fonnum, J. Bakke and Fk. Hansen - Colloid Polym. Sci 271, 380-389 (1993).

[0183] More particularly, a polyurethane polyether is preferred, which can be obtained by polycondensation of at least three compounds comprising (i) at least one polyethylene glycol comprising 150 to 180 moles of ethylene oxide, (ii) stearyl alcohol or decyl alcohol and (iii) at least one diisocyanate.

[0184] Such polyether polyurethanes are sold in particular by the company ROHM & HAAS under the names ACULYN 46® and ACULYN 44® [ACULYN 46® is a polyethylene glycol polycondensate with 150 or 180 moles of ethylene oxide, stearyl alcohol and methylene bis(4-cyclohexyl-isocyanate) (SMDI), at 15% by weight in a matrix of maltodextrin (4%) and water (81%); ACULYN 44® is a polyethylene glycol polycondensate with 150 or 180 moles of ethylene oxide, decyl alcohol and methylene bis(4-cyclohexylisocyanate) (SMDI), at 35% by weight in a mixture of propylene glycol (39%) and water (26%)].

[0185] Preferably, the composition comprises one or more thickening polymers; preferably chosen from non-associative thickening polymers without sugar motifs, anionic associative thickening polymers, in particular anionic associative acrylic polymers, and mixtures thereof.

[0186] Preferably, when the thickening polymer(s) are present in the composition according to the invention, the total content of thickening polymer(s) is in the range of 0.05 to 4% by weight, more preferably 0.1 to 2% by weight, more preferably still 0.2 to 1% by weight, and better 0.3 to 0.8% by weight, relative to the total weight of the composition.

[0187] Additives The composition may also include one or more additives different from the compounds previously described, such as those selected from cationic, anionic, amphoteric or zwitterionic, non-ionic surfactants and mixtures thereof, cationic, anionic, non-ionic, amphoteric polymers or mixtures thereof, anti-dandruff agents, anti-seborrheic agents, vitamins and pro-vitamins including panthenol, sunscreens, sequestering agents, plasticizers, solubilizing agents, acidifying agents, opacifying or pearlescent agents, antioxidants, hydroxy acids, perfumes, preservatives and ceramides.

[0188] Of course, a person skilled in the art will take care to choose this or these possible complementary compounds in such a way that the advantageous properties intrinsically attached to the composition according to the invention are not, or substantially not, altered by the envisaged addition(s).

[0189] The above additives may generally be present in an amount of each of them between 0 and 20% by weight, relative to the total weight of the composition.

[0190] Process The invention also relates to a cosmetic treatment process for human keratinous materials such as skin, in particular scalp, hair and / or eyelashes, comprising at least the application of the cosmetic composition as defined above.

[0191] The composition according to the present invention is preferably applied topically, in particular on the scalp and / or hair.

[0192] The application of the composition may or may not be followed by rinsing after a possible waiting period.

[0193] Preferably, the application of the composition according to the invention is not followed by rinsing.

[0194] Preferably, the cosmetic treatment process is a hair and / or scalp care process.

[0195] The present invention also relates to the use of a cosmetic composition as defined above to treat the loss, and / or promote the regrowth, of keratin fibers.

[0196] The present invention also relates to the use of a cosmetic composition as defined above to increase the diameter of keratin fibers and / or strengthen keratin fibers against breakage.

[0197] The following examples serve to illustrate the invention without, however, being limiting in nature.

[0198] Examples In the following examples, all quantities are given as mass percentage of active material (AM) relative to the total weight of the composition (unless otherwise stated).

[0199] a) Compositions Compositions A to D according to the present invention and the comparative composition E were prepared from the ingredients whose contents are indicated in the tables below:

[0200] [Tables 1] Composition A (invention) Composition B (invention) Composition C (invention) Composition D (invention) Composition E (comparative) Propylene glycol 2.5 2.5 2.5 2.5 - Niacinamide 3 3.5 3 3 3 Ginger root extract 0.1 0.1 0.1 0.1 0.1 Diaminopyrimidine oxide 1.5 1.5 1.5 1.5 1.5 Piroctone olamine 0.25 0.25 0.25 0.25 0.25 Acrylates / Beheneth-25 Methacrylate copolymer 0.45 0.53 0.6 0.45 0.6 PEG-40 castor oil 0.1 0.1 0.1 0.3 0.1 Ethanol 27 37.5 37.5 30 40 Water Qsp 100 Qsp 100 Qsp 100 Qsp 100 Qsp 100

[0201] b) Protocol A test was conducted by expert hairdressers with consumers. The test allowed each consumer to try two formulas, with each product being applied to half of their head.

[0202] On the first day, the scalp is shampooed to cleanse it, removing any remaining product that may have been previously applied by the consumer. The hair and scalp are then partially towel-dried.

[0203] A first application of 3 mL of the product is then carried out on half of the scalp. The scalp is observed. The scalp and hair are then dried and the scalp is observed again.

[0204] The following day, upon the consumers' return, their scalp is examined. A second application of 3 mL of the product is then carried out on the same half of the scalp. The scalp is examined.

[0205] Among the different parameters observed, powdering (appearance of powder) is noted by the hairdressers, and the level of powdering is judged acceptable or unacceptable by the hairdressers who are experts in sensory perception.

[0206] c) Results The results are presented in the table below:

[0207] [Tables2] Composition 1st application, dry hair Back 2nd application Composition A No powder No powder No powder Composition B No powder No powder No powder Composition C No powder No powder No powder Composition D No powder No powder No powder Composition E Powder Powder Powder

[0208] Compositions A to D according to the invention leave no powdery effect (presence of particles) on the scalp or hair after drying of the composition according to the invention.

[0209] The same result is observed after a new application of the compositions after 24 hours, or a very slight powdery effect deemed acceptable by a hairdresser expert in scalp cleanliness.

[0210] Comparative composition E leaves a powdery effect on the scalp and hair.

Claims

Demands

1. Cosmetic composition comprising: i) 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, ii) piroctone olamine, iii) niacinamide, and iv) at least 1% by weight, relative to the total weight of the composition, of one or more hydroxylated compounds having a melting point below 25°C at atmospheric pressure (1.013.105 Pa) and a boiling point greater than or equal to 170°C, selected from linear C2-C8 diols.

2. Composition according to the preceding claim, characterized in that the total content of 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates ranges from 0.05 to 8% by weight, preferably from 0.1 to 5% by weight, preferably from 0.2 to 4% by weight, more preferably from 0.5 to 3% by weight, and better from 1 to 2% by weight, relative to the total weight of the composition.

3. Composition according to any one of the preceding claims, characterized in that the total piroctone olamine content is from 0.05 to 2% by weight, preferably from 0.1 to 1% by weight, preferably from 0.1 to 0.5% by weight, relative to the total weight of the composition.

4. Composition according to any one of the preceding claims, characterized in that the total niacinamide content is from 1 to 5% by weight, preferably from 2 to 5% by weight, relative to the total weight of the composition.

5. Composition according to any one of the preceding claims, characterized in that the hydroxylated compound(s) iv) are selected from linear C2-C6 diols, more preferably propylene glycol.

6. Composition according to any one of the preceding claims, characterized in that the total content of the hydroxylated compound(s) iv) is from 1 to 15% by weight, preferably from 1.5 to 10%, preferably from 2 to 8% by weight, more preferably from 2.1 to 6% by weight, better from 2.2 to 5% by weight, even better from 2.3 to 4% by weight, relative to the total weight of the composition.

7. Composition according to any one of the preceding claims, characterized in that it further comprises a ginger root extract, preferably in a total content of 0.02 to 0.2% by weight, more preferably of 0.05 to 0.2% by weight, relative to the total weight of the composition.

8. Composition according to any one of the preceding claims, characterized in that it further comprises one or more thickening polymers, preferably selected from non-associative thickening polymers without sugar motifs, anionic associative thickening polymers, in particular anionic associative acrylic polymers, and mixtures thereof.

9. A cosmetic treatment process for human keratinous materials such as skin, in particular scalp, hair and / or eyelashes, comprising applying to said keratinous materials a composition as defined in any one of the preceding claims.

10. Use of a composition as defined in any one of claims 1 to 8 to treat the loss, and / or promote the regrowth, of keratin fibers.

11. Use of a composition as defined in any one of claims 1 to 8 to increase the diameter of keratin fibers and / or strengthen keratin fibers against breakage.