Application of soluble dietary fibers in kelp in preparation of lipid-lowering and weight-losing medicines and functional foods

A functional food and dietary fiber technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as waste, environmental pollution, and insufficient utilization of kelp, and achieve low price and safety High sex, good fat-lowering and weight-loss effects

Inactive Publication Date: 2020-02-14
THE FIRST INST OF OCEANOGRAPHY SOA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] According to the recommendation of the "Reference Intake of Dietary Nutrients for Chinese Residents", the recommended per capita intake of dietary fiber is 25-35g, but at present, about 90% of the people in our country still cannot reach the daily recommended amount of dietary fiber in our country. Severely less than one-third of the daily recommended amount
Kelp is a kind of large brown algae. There are a lot of kelp products every year, but the insufficient utilization of kelp has caused a lot of waste, and it has also caused environmental pollution to the environment.

Method used

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  • Application of soluble dietary fibers in kelp in preparation of lipid-lowering and weight-losing medicines and functional foods
  • Application of soluble dietary fibers in kelp in preparation of lipid-lowering and weight-losing medicines and functional foods
  • Application of soluble dietary fibers in kelp in preparation of lipid-lowering and weight-losing medicines and functional foods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The method for extracting soluble dietary fiber in the present invention includes the following steps:

[0036] (1) Soak the kelp residue discarded after extracting the seaweed gum in tap water overnight. After fully swelling, the impurities floating on the liquid are removed, and the wet kelp residue is obtained after filtration. Add 1-3wt% at a material-to-liquid ratio of 1:15-30 Soak in the NaOH solution at room temperature for more than 48h, wash with water until it is neutral, and filter to retain the solid.

[0037] (2) Add an appropriate amount of water and steam explosion for 20-30 minutes under the conditions of temperature ≥ 121°C and pressure ≥ 0.14 MPa to obtain a suspension containing insoluble kelp fibers.

[0038] (3) Add low-temperature cellulase to the suspension containing insoluble kelp fibers, the low-temperature cellulase accounts for 1.5% of the initial weight of the kelp residue in step (1), enzymatically hydrolyze in a water bath at 25℃-35℃ for 24h Abo...

Embodiment 2

[0041] Select SPF male OB mice, age: 6 weeks, body weight: 40±3g; during the experiment, the mice eat and drink freely, and the ventilation is normal. The experimental groupings are as follows: 7 normal control group (C57) C57 mice, gavage solvent water 0.1ml / 10g; 7 negative control (NC) OB mice, gavage solvent water 0.1ml / 10g; high-dose soluble 7 dietary fiber (H-SDF) OB mice were administered intragastrically with a dose of 5000mg / kg kelp soluble dietary fiber 0.1ml / 10g; 7 low-dose soluble dietary fiber (L-SDF) OB mice were administered intragastrically A 1000 mg / kg dose of kelp soluble dietary fiber 0.1ml / 10g was administered; 7 positive control group (PC) OB mice were administered intragastrically with a 200mg / kg dose of metformin 0.1ml / 10g. The body weight was measured at 10 o'clock in the morning and measured once a week for a total of 6 weeks of observation. The highest dose of dietary fiber is calculated according to the recommended amount of the national diet, and the...

Embodiment 3

[0044] The experimental grouping and gavage dose were the same as in Example 1. The mice after six weeks of intervention were fasted for 12 hours, then blood was taken from the orbit after ether anesthesia, and the whole blood was allowed to stand at room temperature for 30 minutes, and then centrifuged at 4°C and 7500 rpm / min 15min, the serum is separated for detection of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C).

[0045] The experimental results show that: Kelp soluble dietary fiber effectively reduces the blood lipid content in the serum of obese mice, as shown in Table 1.

[0046] Table 1 is a table of changes in blood lipids in mouse serum

[0047]

[0048]

[0049] Note: Compared with the Normal group, P<0.05 is *, compared with the NC group, P<0.05 is #

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Abstract

The invention discloses an application of soluble dietary fibers in kelp in preparation of lipid-lowering and weight-losing medicines and functional foods. The soluble dietary fibers are extracted from the waste kelp residues, after feeding for 3 weeks, the weight of obese mice is remarkably reduced compared with that of a negative control group; after 6 weeks of experiment period, the lipid-lowering effect is obvious; the epididymis fat and the liver of a mouse are subjected to histopathological section, the soluble dietary fibers in the section dyed by HE can obviously reduce the size of thefat, and the fat lesion of the liver of the mouse is relieved. By detecting mRNA expression of related factors related to lipid metabolism in fat and liver and mRNA expression of common inflammatoryfactors in obesity, the soluble dietary fibers can down-regulate expression of lipid synthesis genes and pro-inflammatory factors and up-regulate expression of lipid metabolism genes. The soluble dietary fiber disclosed by the invention is high in safety and low in price, and has a remarkable effect in the aspects of reducing fat and losing weight of OB obese mice.

Description

Technical field [0001] The invention belongs to the field of food and health care, and particularly relates to the application of soluble dietary fiber in kelp in preparing medicines and functional foods for reducing fat and losing weight. Background technique [0002] The topic of obesity nowadays has aroused people's close attention. At present, there are 1.9 billion people who are obese in the world. The global obesity trend will be similar to the incidence of diabetes. According to research statistics, obesity is likely to induce the occurrence of type 2 diabetes and cause obesity. There are many reasons for this, such as: energy intake is higher than the normal consumption of the body, sedentary lack of exercise, irregular life, etc. Obesity has been a global problem. In the past few decades, everyone has generally recognized that a high level of BMI is The official standard for judging obesity. However, in recent years, people believe that obesity is the abnormal accumulati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/03A61P3/06A61P3/04
CPCA61K36/03A61K2236/19A61K2236/51A61P3/04A61P3/06
Inventor 缪锦来曲长凤张丽萍王艳峰曹峻菡
Owner THE FIRST INST OF OCEANOGRAPHY SOA
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