Novel synthetic method for 5-phenyl tetrazole

In the production of 5-phenyltetrazole, the azide reaction is carried out under acidic and alkaline conditions after neutralization of hydrazine hydrate and acid, which solves the problem of sodium azide being explosive and realizes the safety of the process. and high yield improvement.

CN103351352AInactive Publication Date: 2013-10-16姜树林
10 Cites 8 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2013-07-15
Publication Date
2013-10-16
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The sodium azide used in the existing 5-phenyltetrazole production process is explosive, the process is unsafe, and the yield is low.

Method used

Neutralize with hydrazine hydrate and acid, then add a mixed solution of benzonitrile, water and ethanol to generate phenylaminoguanidine salt, which is diazotized with sodium nitrite under acidic conditions, followed by ring-closing reaction under alkaline conditions, and passed through ethanol. Purify to obtain crude 5-phenyltetrazole.

Benefits of technology

The simplicity, safety and high yield of the process are achieved, and the quality of the product is improved.

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Abstract

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.
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Citation Information

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