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Application of acellular fat extracting solution to treatment of lung diseases

A fat extraction, cell-free technology, applied in the field of medicine, can solve the problems of lack of therapeutic drugs, high morbidity, high mortality and lack of treatment methods

Pending Publication Date: 2021-12-17
SHANGHAI SEME CELL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to its high morbidity, high mortality and lack of treatment methods, the current clinical treatment of ALI / ARDS mainly uses mechanical ventilation for respiratory support, glucocorticoids, and pulmonary vasodilators. However, the current treatment methods are difficult to Effectively reduce the mortality rate of ALI / ARDS, there is still a lack of effective treatment drugs

Method used

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  • Application of acellular fat extracting solution to treatment of lung diseases
  • Application of acellular fat extracting solution to treatment of lung diseases
  • Application of acellular fat extracting solution to treatment of lung diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0177] 1.1. Preparation of Cell free fat extract (CEFFE)

[0178] Fat was obtained from volunteers with informed consent. The preparation method of cell-free adipose tissue extract is as follows:

[0179] (1) Adipose tissue was obtained from 6 healthy women who underwent routine liposuction, with an average age of 31 years (24-36 years). After local injection of tumescent fluid for anesthesia, use a 3mm liposuction cannula with a large side hole (2mm x 7mm) to connect to a 20mL syringe, draw radially under artificial negative pressure, stand the obtained fat upright, remove the tumescent fluid, and use Rinse with saline 3 times.

[0180] (2) The adipose tissue after rinsing was taken, placed in a centrifuge tube, and centrifuged at 1200 g at 4° C. for 3 minutes in a centrifuge to obtain a layered mixture.

[0181] (3) For the layered mixture, the upper oil layer and the lower water layer are removed, and the middle layer (ie, the fat layer containing fat cells) is collected...

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Abstract

The invention relates to application of an acellular fat extracting solution to treatment of lung diseases. Specifically, the application of an acellular fat extract is provided and used for preparing a composition or a preparation, and the composition or the preparation is selected from one or more of the following applications: (i) prevention and / or treatment of acute respiratory distress syndrome and / or acute lung injury; (ii) prevention and / or treatment of hypoxemia; (iii) improvement of lung tissue inflammation; (iv) improvement of lung tissue injury; (v) prevention and / or treatment of systemic inflammatory response syndrome; and (vi) prevention and / or treatment of multiple organ function failure. The acellular fat extract can be used for effectively preventing and / or treating acute respiratory distress syndrome, acute lung injury, hypoxemia, lung tissue inflammation, lung tissue injury, systemic inflammatory response syndrome and multi-organ function failure.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the therapeutic application of cell-free fat extract to lung diseases. Background technique [0002] Acute lung injury (ALI) refers to alveolar epithelial cell damage, pulmonary interstitial capillary damage, alveolar and capillary barrier damage caused by various factors, causing edema and inflammation of alveolar and pulmonary interstitium. Cellular infiltration, clinically a disease characterized by dyspnea and hypoxemia. It is estimated that it accounts for about 10% of the number of people admitted to intensive care units worldwide, and the mortality rate can reach more than 40%. Acute respiratory distress syndrome (ARDS) is the most severe stage of acute lung injury, acute hypoxic respiratory failure caused by acute diffuse damage to the lung parenchyma, clinical manifestations are progressive dyspnea and intractable Hypoxemia is characteristic. All along, ALI / ARDS [0003] Due ...

Claims

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Application Information

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IPC IPC(8): A61K35/35A61P11/00A61P29/00
CPCA61K35/35A61P11/00A61P29/00A61P31/00A61K35/32C12N5/0653C12N2500/02
Inventor 张文杰于子优侯曦凡
Owner SHANGHAI SEME CELL TECH CO LTD
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