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Application of cannabidiolin the treatment of pulmonary hypertension
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A technology of pulmonary arterial hypertension and cannabidiol, applied in the field of medicine, can solve the problems of incurable mortality of pulmonary arterial hypertension, lack of cure methods for pulmonary arterial hypertension, etc.
Active Publication Date: 2019-01-25
DEYI PHARMA LTD
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[0007] Although these drugs can alleviate the symptoms of PAH to a certain extent, pulmonary hypertension is still an incurable disease with a high mortality rate. The median survival time of patients under treatment is only 2.7 years. Therefore, it is particularly urgent to find new specific therapeutic drugs
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Embodiment 1
[0086] Example 1: Test of the influence of cannabidiol on pulmonary hypertension caused by hypoxia
[0087] 1. Experimental animals, reagents and instruments
[0088] (1) Experimental animals
[0089] 4-6 weeks old, healthy and lively, with shiny coat color, weighing (25.15±2.15) g, C57BL / 6 (Experimental Animal Center of Military Science and Medical College, SPF grade). Divided into four groups:
[0090] Group 1 (normoxic wild type, as a control group): under normoxia, 10 female mice and 10 male mice;
[0091] Group 2 (anoxic wild type, as a control group): under hypoxic conditions, 10 female mice and 10 male mice;
[0092] Group 3 (10mg / kg, experimental group): gavage treatment under hypoxic conditions, 10 female mice and 10 male mice at 10mg / kg;
[0093] Group 4 (50 mg / kg, experimental group): intragastric administration under hypoxic conditions, 10 female mice and 10 male mice at 50 mg / kg.
[0094] (2) Administration method
[0095] The mice in groups 2-4 were place...
Embodiment 2
[0152] Example 2: In vitro experiment of cannabidiol treatment of LPS-induced macrophages
[0153] 1. Experimental animals, reagents and instruments
[0154] 2-month-old C57BL / 6 mice (Experimental Animal Center, Military Science Medical College, SPF grade)
[0160] Primary alveolar macrophages were isolated according to the method of Yang et al. (Yang, H.M., Ma, J.Y., Castranova, V., and Ma, J.K. (1997). Effects of diesel exhaust particles on the release of interleukin-1 and tumor necrosis factor- alpha from rat alveolarmacrophages. Experimental lung research 23, 269-284.): 2-month-old mice were taken, and the animals were anesthetized by intraperitoneal injection of pentobarbital. Fix the patient in a supine position, disinfect the neck, cut the skin of the neck, peel o...
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Abstract
The invention belongs to the medical field and relates to the application of cannabidiol (CBD) in the treatment of pulmonary hypertension. The cannabidiol can be used as a sole active ingredient or incombination with other active ingredients to prepare a drug for treating pulmonary hypertension.The present invention relates to the use of any one of (1) to (3) below for the preparation of a medicament for the treatment and / or prevention of pulmonary hypertension:(1) cannabidiol, (2) a plant extract containing cannabidiol, preferably, the plant extract is a cannabis extract, and (3) a pharmaceutical composition comprising cannabidiol and one or more pharmaceutically acceptable adjuvants. The invention finds out the effect of cannabidiol on inhibiting pulmonary hypertension through experimental research, and is especially suitable for treating pulmonary hypertension caused by hypoxemia.
Description
technical field [0001] The invention belongs to the field of medicine and relates to the application of cannabidiol in the treatment of pulmonary hypertension. Background technique [0002] Pulmonary arterial hypertension (PAH) has complex etiology and is caused by a variety of heart, lung or pulmonary vascular diseases. Pulmonary arterial hypertension is characterized by pulmonary arteriolar vascular remodeling and pulmonary arteryvascular smooth muscle proliferation, manifested by increased pulmonary circulation pressure and resistance, increased right heart load, right heart dysfunction, and reduced pulmonary blood flow, resulting in a series of clinical manifestations ; During the course of the disease, pulmonary hypertension often develops progressively. In particular, right heart failure caused by enhanced pulmonary artery vascular tension is a disease that seriously threatens human life and health. [0003] Pulmonary hypertension is divided into primary and seconda...
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