Use of quercetin in preparation of a medicament for regulating NLRP3 / caspase-3 pathway to treat knee osteoarthritis

Quercetin addresses the issue of relying on a single mechanism in the treatment of knee osteoarthritis by regulating the NLRP3/Caspase-3 signaling pathway and the antioxidant pathway, achieving comprehensive regulation of inflammatory response, oxidative stress, and cartilage protection.

CN122398779APending Publication Date: 2026-07-17GANSU PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GANSU PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Filing Date
2026-05-07
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Current treatments for knee osteoarthritis have a single mechanism of action and cannot simultaneously address inflammation regulation, cell damage inhibition, and cartilage protection.

Method used

Quercetin inhibits inflammatory responses and apoptosis by regulating the NLRP3/Caspase-3 related signaling pathway, activates antioxidant pathways, inhibits cartilage matrix degradation, and promotes the expression of cartilage phenotype-related proteins.

Benefits of technology

Quercetin intervenes in knee osteoarthritis at the molecular level, reducing inflammation, inhibiting oxidative damage, protecting chondrocytes, and comprehensively regulating inflammation, oxidative stress, and cartilage damage, providing a multi-target synergistic intervention effect.

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Abstract

本发明涉及医药技术领域，公开了槲皮素在制备用于治疗膝骨关节炎的药物中的应用。所述槲皮素可通过调控NLRP3炎症小体及Caspase‑3相关信号通路，抑制炎症反应及细胞凋亡过程，降低炎症因子TNF‑α和IL‑1β的表达水平；同时，通过调控Nrf2 / HO‑1抗氧化通路，提高细胞抗氧化能力，并促进SOX9表达、抑制ADAMTS4表达，从而在炎症调控、氧化损伤抑制及软骨保护方面发挥作用。本发明为槲皮素治疗膝骨关节炎提供了新的应用。
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