External medicine for treating acne and preparation method thereof

Abstract

The invention provides an external medicine for treating acne and a preparation method thereof.The external medicine is prepared from sulfadiazine powder, salicylic acid powder, menthol, metronidazole powder, tannic acid powder and alcohol thereof.The external medicine takes sulfadiazine, salicylic acid, menthol, metronidazole and tannic acid as main active ingredients, aims at various factors causing the acne, and has the advantages that the effect of treating the acne is achieved; through cooperation of the raw materials, the effects of sterilizing, diminishing inflammation, relieving itching, degreasing, inhibiting sebum secretion and the like can be achieved, acne can be effectively treated, pigmentation after acne can be improved through mild epidermis exfoliation, skin regeneration at the skin lesion position is facilitated, and the recovered skin lesion position is free of pigmentation and scar. According to the invention, alcohol is used as a matrix, organic active components such as sulfadiazine, salicylic acid, menthol, metronidazole and tannic acid are organically combined, bacterial protein can be denatured, the effect of synergistic sterilization is achieved, and the curative effect of acne treatment is improved. Through application verification, the traditional Chinese medicine composition can also have a good curative effect on epifolliculitis, especially infectious epifolliculitis, and can also be applied to effective treatment on epifolliculitis and acne combined epifolliculitis thereof.

Description

Technical Field

[0001] The present invention relates to the technical field of medicines, and in particular to an external medicine for treating acne and a preparation method thereof. Background Art

[0002] Acne is a common chronic inflammatory skin disease of hair follicles and sebaceous glands caused by a variety of factors, and it is common in adolescents. It usually occurs on the face, neck and upper trunk, where the sebaceous follicles are most densely populated in the population, and the face is the main site of occurrence. Severe acne places a great psychological burden on patients. The clinical manifestations of acne are acne, papules, pustules, nodules, cysts and scars. Current studies believe that the pathogenesis of acne is mainly related to the following four factors: excessive sebum secretion, excessive keratinization at the opening of the hair follicle sebaceous gland duct, Propionibacterium acnes reproduction and inflammatory response, and the pathogenic factors are complex. However, some of the current drugs for the treatment of acne have a single efficacy, and the effect on acne, especially moderate and severe treatment, is poor and cannot meet the needs. Summary of the invention

[0003] Therefore, based on the above background, the present invention proposes an external medicine for treating acne and a preparation method thereof, which can have a good therapeutic effect on acne of different degrees.

[0004] The technical solution of the present invention is:

[0005] An external medicine for treating acne, which is made from the following raw materials by weight:

[0006] Sulfadiazine powder 9-12g, salicylic acid powder 4-6g, menthol 9-12g, metronidazole powder 9-12g, tannic acid powder 9-12g, alcohol 1000ml.

[0007] Preferably, it is made of the following raw materials by weight:

[0008] Sulfadiazine powder 9g, salicylic acid powder 4g, menthol 9g, metronidazole powder 9g, tannic acid powder 9g, alcohol 1000ml.

[0009] Preferably, it is made of the following raw materials by weight:

[0010] Sulfadiazine powder 10g, salicylic acid powder 4g, menthol 9g, metronidazole powder 11g, tannic acid powder 9g, alcohol 1000ml.

[0011] Preferably, the alcohol is 75% (volume fraction) alcohol.

[0012] Preferably, the preparation method comprises the following steps:

[0013] 1) Take each raw material according to the amount;

[0014] 2) Add the other raw materials except tannic acid powder into alcohol and stir until completely dissolved;

[0015] 3) Add tannic acid powder to alcohol, stir until completely dissolved, seal and let stand to clarify, then filter and take the clear liquid.

[0016] Furthermore, the menthol can be replaced by camphor.

[0017] Based on the same inventive concept, the present invention applies the above-mentioned external medicine to prepare a medicine for treating folliculitis.

[0018] Furthermore, the folliculitis is infectious folliculitis, and the infectious folliculitis includes folliculitis caused by at least one of Staphylococcus aureus, Gram-negative bacteria, and Malassezia.

[0019] Based on the same inventive concept, the present invention applies the above-mentioned external medicine to prepare a medicine for treating acne combined with infectious folliculitis.

[0020] The above technical solution has the following beneficial effects:

[0021] The invention uses sulfadiazine, salicylic acid, menthol, metronidazole and tannic acid as main active ingredients, and can play the roles of sterilization, anti-inflammatory, antipruritic, degreasing, inhibiting sebum secretion, etc. for various factors causing acne. Acne can be effectively treated and pigmentation after acne can be improved through mild epidermal exfoliation, and skin regeneration at the lesion is beneficial. After recovery, the lesion has no pigmentation and no scars.

[0022] The invention uses alcohol as a matrix, organically combines sulfadiazine, salicylic acid, menthol, metronidazole and tannic acid organic active ingredients, and can also denature bacterial proteins, thereby enhancing the bactericidal effect and improving the therapeutic effect on acne.

[0023] And the present invention has been verified through application, and it can also have a good therapeutic effect on folliculitis, especially infectious folliculitis, and it can also be used to effectively treat folliculitis and acne combined with folliculitis. DETAILED DESCRIPTION

[0024] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0025] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0026] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0027] Example 1: An external medicine for treating acne, which is made from the following raw materials by weight:

[0028] Sulfadiazine powder 9g, salicylic acid powder 4g, menthol 9g, metronidazole powder 9g, tannic acid powder 9g, alcohol 1000ml.

[0029] Example 2: An external medicine for treating acne, which is made from the following raw materials by weight:

[0030] It is made of the following raw materials by weight:

[0031] Sulfadiazine powder 10g, salicylic acid powder 4g, menthol 9g, metronidazole powder 11g, tannic acid powder 9g, alcohol 1000ml.

[0032] Example 3: An external medicine for treating acne, which is made from the following raw materials by weight:

[0033] Sulfadiazine powder 9g, salicylic acid powder 4g, camphor 9g, metronidazole powder 9g, tannic acid powder 9g, alcohol 1000ml.

[0034] Example 4: An external medicine for treating acne, which is made from the following raw materials by weight:

[0035] It is made of the following raw materials by weight:

[0036] Sulfadiazine powder 10g, salicylic acid powder 4g, camphor 9g, metronidazole powder 11g, tannic acid powder 9g, alcohol 1000ml.

[0037] The alcohol used in Example 1 to Example 4 is 75% (volume fraction) alcohol.

[0038] The preparation method of the external-use medicine of Examples 1 to 4 comprises the following steps:

[0039] 1) Take each raw material according to the amount;

[0040] 2) Add the other raw materials except tannic acid powder into alcohol and stir until completely dissolved;

[0041] 3) Add tannic acid powder to alcohol, stir until completely dissolved and brown in color, seal and let stand for 24 hours to clarify, then filter and take the clear liquid.

[0042] Wherein the menthol or camphor in the above embodiment is ground into powder before adding alcohol.

[0043] The external-use medicines prepared in Examples 1 to 4 can be prepared into sprays.

[0044] During specific use, spray it on the affected area three times a day, put on sterile gloves and massage for absorption.

[0045] Alternatively, you can use sterile gauze or a sterile cotton swab to gently apply to the affected area three times a day, and then massage with light pressure to absorb.

[0046] Comparative Example: An external medicine for treating acne, which is made from the following raw materials by weight:

[0047] It is made of the following raw materials by weight:

[0048] Sulfadiazine powder 10g, salicylic acid powder 4g, menthol 9g, metronidazole powder 11g, tannic acid powder 9g;

[0049] Its preparation method is:

[0050] Take 750g of vaseline as the base, mix 10g of sulfadiazine powder, 4g of salicylic acid powder, 9g of menthol, 11g of metronidazole powder, and 9g of tannic acid powder with vaseline, seal and stir for 4-5h, then seal and set aside.

[0051] The sulfadiazine powder used in the present invention can inhibit bacterial growth and reproduction, can resist infection, and inhibit the formation of ulcers, wounds and abscesses. Menthol or camphor can inhibit bacteria and relieve itching, promote local blood circulation, and relieve swelling. Metronidazole powder has a killing effect on anaerobic organisms, inhibits the DNA metabolism process of bacteria, inhibits the synthesis of deoxyribonucleic acid of bacteria, interferes with the growth and reproduction of bacteria and causes cell death, and has an inhibitory effect on acne corynebacterium. Tannic acid has the effect of inhibiting bacterial growth and reproduction, mainly by interfering with the synthesis of synthetic protein of bacterial cell wall to achieve antibacterial, has astringent hemostasis, anti-inflammatory, and can shrink pores to reduce skin oil secretion, anti-oxidation, and improve skin texture. Salicylic acid powder removes stratum corneum, regulates skin oil metabolism, improves blackhead acne on the skin surface, and has antimicrobial, anti-inflammatory, and penetration-promoting effects. Alcohol is not only a commonly used external disinfectant, but can denature bacterial proteins and play a bactericidal role, and allows sulfadiazine, salicylic acid, menthol, metronidazole, and tannic acid organic active ingredients to be organically combined.

[0052] Example 5: Verification of the therapeutic application for acne

[0053] A retrospective analysis was conducted on 46 patients from Beijing Zhonghao Guoyan Chinese and Western Medicine Clinic from January 2020 to February 2024, aged between 15 and 35 years, including 25 males and 21 females, with a disease course ranging from 6 months to 2 years. All patients were diagnosed with moderate to severe acne according to the diagnostic criteria for moderate to severe facial acne in the "Guidelines for the Treatment of Acne in China (2019 Revised Edition)". Exclusion criteria: allergic to sulfadiazine, salicylic acid, menthol or camphor, metronidazole, tannic acid, alcohol; patients with other skin diseases; pregnant women and lactating women. Pillsbury grading: 22 cases of grade 2, 16 cases of grade 3, and 8 cases of grade 4.

[0054] Among the above patients, 31 patients were treated with the topical medication of Example 2, hereinafter referred to as the alcohol group, and the other 15 patients were treated with the topical medication of the comparative example, hereinafter referred to as the vaseline group. During the treatment, the topical medication was applied to the affected area three times a day. After one month of continuous treatment, a review was conducted and statistics were made on the treatment situation. During the treatment, the medication was stopped after the affected area was healed.

[0055] Efficacy criteria:

[0056] The course of treatment was determined by the degree of improvement of skin lesions, and the efficacy was divided into 4 levels.

[0057] The number of comedones, red papules, and pustules before and after the last treatment was counted and the lesion regression rate was estimated: lesion regression rate = (total number of lesions before treatment - total number of lesions after treatment) * 100% / total number of lesions before treatment.

[0058] Recovery: skin lesion disappearance rate ≥ 90%;

[0059] Significantly effective: 70%≤skin lesion disappearance rate<90%;

[0060] Improvement: 30%≤skin lesion regression rate<70%;

[0061] Ineffective: Skin lesion regression rate <30%.

[0062] Total effective rate = cure rate + marked effective rate + improvement rate

[0063] The results are as follows:

[0064] Alcohol group: 15 cases were cured, 9 cases were markedly effective, 5 cases were effective, 2 cases were ineffective, and the effective rate was 93.5%;

[0065] Vaseline group: 4 cases were cured, 3 cases were significantly effective, 5 cases were effective, 3 cases were ineffective, and the effective rate was 78.2%.

[0066] It can be clearly seen from the above that when alcohol is used as the matrix for the treatment of acne, the cure rate and the effective rate are significantly improved, that is, using alcohol as the matrix is ​​beneficial to improving the therapeutic efficacy of the drug on acne.

[0067] The affected areas of the patients in the alcohol group were observed after recovery, and the skin was smooth, without pigmentation and scars.

[0068] Example 6: Verification of the therapeutic application of acne combined with folliculitis

[0069] A review of 13 patients from Beijing Zhonghao Guoyan Chinese and Western Medicine Clinic from August 2020 to May 2023 was conducted. The patients were aged between 21 and 41 years old, including 7 males and 6 females. All of the patients were diagnosed with acne on their faces, and had Malassezia folliculitis in the acne lesions. It was obvious that the acne lesions worsened in a short period of time. The rash was relatively consistent in shape, equal in size, dense but not fused, accompanied by slight itching, and spores or hyphae could be found under microscopy. The Pillsbury grades of the patients were all 2 and 3.

[0070] Exclusion criteria: patients allergic to sulfadiazine, salicylic acid, menthol or camphor, metronidazole, tannic acid, and alcohol; patients with other skin diseases; pregnant women or lactating women.

[0071] The above patient was treated with Example 2 for two consecutive weeks, and the treatment results were statistically analyzed.

[0072] Efficacy criteria:

[0073] Cured: Skin lesion disappearance rate ≥ 90%, fungal microscopy is negative;

[0074] Significantly effective: 70% ≤ skin lesion disappearance rate < 90%, fungal microscopic examination is negative;

[0075] Improvement: 30% ≤ skin lesion regression rate < 70%, fungal microscopy is positive;

[0076] Ineffective: The skin lesion regression rate is less than 30%, and fungal microscopy is positive.

[0077] The treatment results are as follows:

[0078] 2 patients were cured, 3 patients showed marked improvement, 5 patients were improved, 3 patients were ineffective, and the effective rate was 76.9%.

[0079] Example 7: Typical Case

[0080] Case 1: Xu, female, 17 years old, first diagnosed on June 8, 2020, complained of facial acne for more than a year, with recurring episodes in the past six months;

[0081] Diagnosis: There are scattered papules in the middle and lower parts of both sides of the face, local itching, and mild redness around them. The external use medicine of Example 2 was applied to the affected area three times a day. After continuous treatment for 3 days, the patient felt that the acne symptoms were alleviated. After 10 days, the acne lesions completely disappeared and the patient was cured.

[0082] Case 2: Yang, female, 24 years old, first visited the hospital on March 18, 2021, complaining of acne on the face and back for many years, with occasional recurrences.

[0083] Diagnosis: There are papules of varying sizes on both sides of the face and back, with local burning and itching, and the symptoms worsen every time the menstruation comes; the clinical diagnosis is papular acne, and the external medication of Example 2 is used to wipe the affected area for treatment three times a day. The burning and itching of the skin disappears significantly, and the range of the papules continues to shrink. After one week of continuous treatment, the papules completely disappear. After one week of consolidation treatment, after follow-up, feedback is that there is no recurrence of papules.

[0084] Case 3: Kong, male, 16 years old, first diagnosed on April 8, 2022, complained of facial acne for more than half a year.

[0085] Diagnosis: There are papules of varying sizes on both sides of the face, with local redness, swelling, itching and pain. The patient was treated with the external medicine of Example 1 using a cotton swab three times a day, and the skin pain was significantly improved immediately. After 7 days of continuous treatment, the papules disappeared completely.

[0086] Case 4: Liang, male, 25 years old, first visited the hospital on November 5, 2022, and complained of suffering from acne for more than 5 months.

[0087] Diagnosis: There were scattered papules on both sides of the face, chest and back, accompanied by pustules, and the patient was diagnosed with pustular acne. The patient was treated by wiping with the external medication of Example 2 three times a day. After three weeks of continuous treatment, the pustules and papules disappeared.

[0088] Case 5: Liu, female, 20 years old, first diagnosed on March 4, 2023, complained of facial acne for more than 4 months. Diagnosed as papular acne, the topical medication of Example 1 was used to wipe the affected area for treatment. After 2 consecutive days of treatment, the range of facial papules was significantly reduced, the pain and itching were alleviated, and after one week, the papules completely disappeared.

[0089] Case 6: Sun, female, 25 years old, first visited the hospital on June 22, 2023, complaining of facial acne for more than 5 months.

[0090] Diagnosis: There are scattered papules of varying sizes in the middle and lower parts of both sides of the face, with local burning, itching and pain. The external medication of Example 2 is used to wipe the affected area for treatment three times a day. After one week, the papules have disappeared significantly. After continuing the treatment for one week, the papules have completely disappeared.

[0091] Case 7: Wei, female, 24 years old, first visited the hospital on August 20, 2023, complaining of acne on her face and back for nearly a year.

[0092] Diagnosis: There were pea-sized dark red hard nodules on the middle and lower parts of both sides of the face, and papules on the back. There was a distending pain when pressing locally. The external medication of Example 2 was used to wipe the affected area for treatment. After 3 days of continuous treatment, the nodules softened and the papules were reduced in size. After 4 weeks of continuous treatment, the nodules and papules disappeared completely.

[0093] Case 8: Ma, male, 34 years old, first visited the hospital in January 2014, complaining of acne for 3 years, with recurring attacks in the past 2 years.

[0094] Diagnosis: There are cysts of varying sizes on both sides of the face, containing viscous secretions, and there is a sense of fluctuation when pressed. The affected areas are wiped with the external medicine of Example 2 for treatment. After continuous treatment for 1 week, the abscesses gradually shrink. After 40 days, there is no sense of fluctuation in the cysts. The cysts continue to shrink and disappear with continued treatment.

[0095] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An external medicine for treating acne, characterized in that: It is made of the following raw materials by weight: Sulfadiazine powder 9-12g, salicylic acid powder 4-6g, menthol 9-12g, metronidazole powder 9-12g, tannic acid powder 9-12g, alcohol 1000ml.

2. The external-use medicine for treating acne according to claim 1, characterized in that: It is made of the following raw materials by weight: Sulfadiazine powder 9g, salicylic acid powder 4g, menthol 9g, metronidazole powder 9g, tannic acid powder 9g, alcohol 1000ml.

3. The external-use medicine for treating acne according to claim 1, characterized in that: It is made of the following raw materials by weight: Sulfadiazine powder 10g, salicylic acid powder 4g, menthol 9g, metronidazole powder 11g, tannic acid powder 9g, alcohol 1000ml.

4. The external-use medicine for treating acne according to any one of claims 1 to 3, characterized in that: The alcohol is 75% (volume fraction) alcohol.

5. The external-use medicine for treating acne according to any one of claims 1 to 4, characterized in that: The preparation method thereof comprises the following steps: 1) Take each raw material according to the amount; 2) Add the other raw materials except tannic acid powder into alcohol and stir until completely dissolved; 3) Add tannic acid powder to alcohol, stir until completely dissolved, seal and let stand to clarify, then filter and take the clear liquid.

6. The external-use medicine for treating acne according to any one of claims 1 to 5, characterized in that: The menthol can be replaced by camphor.

7. Use of the external-use medicine according to any one of claims 1 to 6 in the preparation of a medicine for treating folliculitis.

8. The use according to claim 7, characterized in that: The folliculitis is infectious folliculitis, and the infectious folliculitis includes folliculitis caused by at least one of Staphylococcus aureus, Gram-negative bacteria, and Malassezia.

9. Use of the external-use medicine according to any one of claims 1 to 6 in the preparation of a medicine for treating acne combined with infectious folliculitis.