External preparation containing sirolimus as well as preparation method and application thereof
An external preparation, the technology of sirolimus, applied in the field of medicine, achieves the effect of good drug absorption, high safety and good stability
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Embodiment 1
[0131] Single Cream Prescription:
[0132] component name
Dosage
Sirolimus
5g
stearic acid
40g
Glyceryl monostearate
40g
vaseline
20g
liquid paraffin
70g
Glycerin
50g
Triethanolamine
3g
Sodium dodecyl sulfate
3g
Laurocaprazine
2g
purified water
Appropriate amount
Full amount
1000g
[0133] Preparation Process:
[0134] (1) Oil phase: Accurately weigh stearic acid, glyceryl monostearate, vaseline, and liquid paraffin, heat and melt on a water bath, stir well, and keep warm at about 75°C;
[0135] (2) Water phase: Accurately weigh glycerin, triethanolamine, laurocapram, sodium lauryl sulfate and water, heat and stir in a water bath to dissolve, and heat to 75°C.
[0136] (3) Slowly add the above oil phase into the water phase, stir for 15 minutes, and keep stirring.
[0137] (4) Turn on the cooling water, start cooling down to about 5...
Embodiment 2
[0140] Single Cream Prescription:
[0141] components
Dosage
Sirolimus
10g
stearic acid
30g
Glyceryl monostearate
60g
vaseline
20g
liquid paraffin
30g
Glycerin
30g
Triethanolamine
5g
purified water
Appropriate amount
Full amount
1000g
[0142] Preparation Process:
[0143] (1) Oil phase: Accurately weigh stearic acid, glyceryl monostearate, vaseline, and liquid paraffin, heat and melt on a water bath, stir well, and keep warm at about 75°C;
[0144] (2) Water phase: Accurately weigh glycerin, triethanolamine, laurocaprazine and water, heat and stir in a water bath to dissolve, and heat to 75°C.
[0145] (3) Slowly add the above oil phase into the water phase, stir for 15 minutes, and keep stirring.
[0146] (4) Turn on the cooling water, start cooling down to about 55°C, add the prescribed amount of sirolimus, and continue stirring.
[0147] (5) When the...
Embodiment 3
[0149] Compound Cream Prescription:
[0150] components
Dosage
Sirolimus
1g
triamcinolone acetonide
2g
stearic acid
100g
liquid paraffin
120g
lanolin
20g
Glycerin
40g
Triethanolamine
8ml
purified water
Appropriate amount
quantity
1000g
[0151] Preparation Process:
[0152] Weigh stearic acid, liquid paraffin, and lanolin in the same container, heat to 80°C, stir well, and use it as the oil phase for later use; take glycerin, triethanolamine and water in another container, heat to 80°C, Stir well and use as the water phase for later use; add the oil phase to the water phase and stir, and when the temperature drops to 60°C, add the prescribed amount of sirolimus and triamcinolone acetonide, and stir evenly; Pack and serve.
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