Application of single nucleotide polymorphic rs3888722 in screening pemphigus foliaceus patients
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- SHANDONG PROVINCIAL INST OF DERMATOLOGY & VENEREOLOGY
- Publication Date
- 2017-03-22
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Abstract
Description
technical field
[0001] The invention relates to the application of single nucleotide polymorphism rs3888722 in screening pemphigus foliaceus patients in the field of biotechnology. Background technique
[0002] Pemphigus is a rare, life-threatening autoimmune bullous skin disease (Stanley, 1989; Nousari and Anhalt, 1999) characterized by the presence of autoantibodies against keratinocyte adhesion molecules and the absence of keratinocytes. Form the adhesion function between cells. The incidence of pemphigus is 0.76-6.7 per million person-times per year, with differences among different races and regions (Ahmed et al., 1990; Bystryn and Rudolph, 2005; Meyer and Misery, 2010). Although the disease is currently treated with long-term systemic administration of glucocorticoids and immunosuppressants (Loiseau et al., 2000), the mortality rate due to pemphigus in the United States is close to 10% (Lombardi et al., 1996 ), and the current treatment options have significant side ...