Preparation method for traditional Chinese medicine preparation treating pemphigus

Abstract

The invention discloses a preparation method for a traditional Chinese medicine preparation treating pemphigus. The traditional Chinese medicine preparation comprises the following bulk drugs: tip of licorice root, realgar, common dysosmatis rhizome and root, herb of denseleaf crazyweed, galla chinensis, donkey-hide glue, rhizoma atractylodis macrocephalae, radix aucklandiae, radix polygalae, radix asteris, fructus trichosanthis, radix peucedani, root of woolly tylophora, semen sterculiae lychnophorae, elecampane inula root, lablab purpureus, dace, waternut herb, caragana sinica root, semen cuscutae, borneolum syntheticum, radix sophorae flavescentis, giant typhonium tuber, pericarpium zanthoxyli and corydalis boweri. The dosage form of the traditional Chinese medicine preparation is a granula, and the concrete preparation process comprises: mixing, grinding, immersing, boiling, separating out a first decoction, and performing the same process to separate out a secondary decoction, mixing the decoctions, performing centrifugal separation and drying, adding cane sugar and beta-cyclodextrin, and preparing the granula. Compared with the prior art, the traditional Chinese medicine preparation has the efficacy of clearing heat and detoxifying, regulating qi and blood, promoting qi circulation and moistening lung, nourishing stomach and fortifying spleen, dispelling dampness and relieving pain, and relieving nidus, and is relatively strong in pertinency.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of a traditional Chinese medicine preparation for treating pemphigus. Background technique [0002] Pemphigus is a chronic, relapsing, severe intraepidermal acantholytic bullous dermatosis. Antibodies against cadherin, a Ca[sup]2+[ / sup]-dependent intercellular adhesion molecule, exist in the patient's body. Therefore, flaccid blisters appear on normal skin or mucous membranes, and Nissl's sign is positive. [0003] Pemphigus is an autoimmune disease. Indirect immunofluorescence examination found that there were specific antibodies against the intercellular substances of epidermal acanthus in the patient's serum, that is, pemphigus antibodies, mainly IgG. The pemphigus antibody titer in the serum is positively correlated with the severity of the disease, and the reaction site of the pemphigus antibody is the onset site of pemphigus in histopathology. The pe...

AI Technical Summary

Problems solved by technology

[0005] In the existing treatment process, glucocorticoids are generally used for treatment, but the dose control of this hormone is very critical, especially pemphigus mainly occurs in middle-aged and elderly people, and the use of glucocorticoids is likely to cause complications. During the treatment process, nearly Half of the patients died of complications of glucocorticoids, such as respiratory infection, pulmonary embolism, diabetes and peptic ulcer, so we must always be alert to the occurrence of adverse reactions and take corresponding measures in time

[0006] In addition, even if it is cured at that time, its recurrence rate is also high, which will cause relatively large adverse effects on the patient's economy, body, and psychology. Based on this, a preparation method of a traditional Chinese medicine preparation for treating pemphigus is now provided. Blood, detoxification, clearing heat, invigorating the spleen, nourishing the lungs, relieving pain, relieving itching, etc., to achieve both the symptoms and root causes of pemphigus