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GABA and electrophysiology micro-nano synchronous sensing detection chip and preparation method thereof

A detection chip, electrophysiological technology, applied in chemical instruments and methods, measuring devices, fluid controllers, etc., can solve the problems of GABA neurotransmitter lack of electroactive groups, difficulty in real-time detection, etc., and achieve real-time synchronization in situ directly. Probing, Aided Survival and Adhesion, Good Biocompatibility Effects

Active Publication Date: 2020-03-31
INST OF ELECTRONICS CHINESE ACAD OF SCI
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Problems solved by technology

The detection of GABA neurotransmitter has caused great difficulties in real-time detection in vivo due to its lack of electroactive groups and unique specific enzymes

Method used

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  • GABA and electrophysiology micro-nano synchronous sensing detection chip and preparation method thereof
  • GABA and electrophysiology micro-nano synchronous sensing detection chip and preparation method thereof
  • GABA and electrophysiology micro-nano synchronous sensing detection chip and preparation method thereof

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Embodiment Construction

[0051] The disclosure provides a GABA and electrophysiological micro-nano synchronous sensing and detection chip and its preparation method, wherein the micro-nano synchronous sensing and detection chip includes: a base layer, a conductive layer and an insulating layer; the base layer is a flexible material, and the base layer Covered on the bottom support; a conductive layer is formed on the base layer, and is used to synchronously detect changes in the inhibitory neurotransmitter GABA and nerve electrical signals in many different sub-regions of the hippocampal structure of rats; the conductive layer includes : The detection site group, whose distribution position matches the size of the rat hippocampus, said detection site group radiates along the diagonal direction of the detection area and is distributed in different sub-regions of the rat hippocampus; the insulating layer is a flexible material , the insulating layer is formed on the base layer except the area where the d...

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Abstract

The invention provides a GABA and electrophysiological micro-nano synchronous sensing detection chip and a preparation method thereof. The micro-nano synchronous sensing detection chip comprises a substrate layer, a conductive layer and an insulating layer, wherein the substrate layer is made of a flexible material and covers a bottom support; the conductive layer is formed on the substrate layerand used for synchronously detecting changes of inhibitory neurotransmitter GABA and neuroelectric signals in multiple different sub-regions of a rat hippocampus structure; the conductive layer comprises detection site groups which are distributed at positions matching with the size of the rat hippocampus structure and distributed in different sub-regions of the rat hippocampus structure in a radiation manner along the diagonal direction of a detection region; and the insulating layer is made of a flexible material and is formed on the substrate layer except the area where the detection site groups are located. According to the invention, the inhibitory neurotransmitter and the electrical signals can be synchronously detected, and a microprocessing technology, a nanometer material and a biologically sensitive film technology are combined, so the neural information network and the pathogenesis of neurodegenerative diseases can be easily found and understood.

Description

technical field [0001] The disclosure relates to the field of micro-processing technology of biosensors, in particular to a micro-nano synchronous sensing and detection chip for epileptic hippocampal slices of γ-aminobutyric acid and neural electrical activity and a preparation method thereof. Background technique [0002] The brain is composed of a large number of synapses, and the synapses carry out the interactive transduction of nerve signals through the two transmission methods of neurotransmitters and nerve electrical signals to complete our daily behavior, motor learning and other functional activities. Abnormal release of neurotransmitters between synapses or abnormal discharge of electrical signals may indicate the existence of potential neurological diseases. Simultaneously detecting the changes of the two dual-mode signals will help to obtain neurocytopathy in advance, and help to grasp and understand the pathogenic mechanism of neurological diseases and find more...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N27/00G01N27/26
CPCB01L3/502707B01L3/50273B01L2200/10B01L2300/0645B01L2300/0861B01L2300/12B01L2400/0415B01L2400/046G01N27/00G01N27/26
Inventor 肖桂花蔡新霞宋轶琳徐声伟张禹李欣蓉谢精玉戴玉川王昊陆泽营
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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