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Anxiolytic drug and preparation method thereof

An anti-anxiety and drug technology, which is applied in the field of anti-anxiety drugs and their preparation, can solve problems such as few, only newly launched in recent years, unsatisfactory patients, high sugar content, etc., achieve obvious effects, simple prescriptions, and improve behavioral ability Effect

Active Publication Date: 2012-03-07
NAVY MEDICINE RES INST OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country has extensive resources of Chinese herbal medicine, a long history of research, and a large potential domestic demand market. However, there are very few varieties of anti-anxiety Chinese medicines that have obtained clinical batch numbers. Only Jiuwei Zhenxin Granules, which have just been launched in recent years, are listed.
It is far from being able to meet the needs of various patients in terms of variety, dosage form and curative effect preference: for example, granules are not suitable for patients with low sugar intake or long-term work in high humidity environments due to their high sugar content and deliquescence characteristics. personnel health needs

Method used

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  • Anxiolytic drug and preparation method thereof
  • Anxiolytic drug and preparation method thereof
  • Anxiolytic drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Select Rhodiola rosea 375g, Hypericum perforatum 250g, Gastrodia elata 225g, Rehmannia glutinosa 300g, pulverize to 300 mesh, soak in 10L of ethanol with a volume concentration of 75% for 10h, decoct and extract in the dark for 1h (repeated 3 times in total), combine the extracts, Let stand for more than 12h, then filter (or centrifuge), and concentrate the filtrate to a relative density of 2.0. After adding hydrochloric acid to adjust the pH value to 4.0 at 45°C, add a 3% gelatin solution by weight until no precipitation occurs; add distilled water to 1.0g crude drug / ml after centrifugation, and add 0.1% gelatin at 40°C Chitosan colloidal solution, stirred at 50r / min for 5min. Stand still for 12 hours and centrifuge to take the supernatant, add distilled water to 1000ml, and obtain the drug extract. Let it stand for 12 hours, filter, stir evenly, put it into a bottle, and test it for later use.

Embodiment 2

[0027] The medicine extract that adopts embodiment 1 method to obtain is tested.

[0028] 1. Effects of drugs on anxiety behavior in mice

[0029] Male Kunming mice, weighing (20±2) g, were randomly divided into groups after 1 week of adaptive feeding. The diazepam group was intragastrically administered normal saline for the first 3 days, followed by intragastric administration of 5 mg / Kg·d diazepam for the next 4 days; the saline group was intragastrically administered equal-volume normal saline (1ml) for 7 consecutive days; the drug group was administered intragastrically for 7 consecutive days Different doses of the extracts of the medicine of the present invention, wherein the crude drug content of the low dose, middle dose and high dose medicine groups are 5g / Kg·d, 10g / Kg·d, 20g / Kg·d respectively. All animals were housed in separate cages according to groups, free to eat and drink, and began to conduct behavioral tests after 7 days. Immediately after the end of the beh...

Embodiment 3

[0046] The process of this embodiment is the same as that of Example 2. Male Kunming mice with a body weight of (20 ± 2) g were randomly grouped after 1 week of adaptive feeding. Animals were divided into groups: normal saline group, diazepam group, drug group, disassembled recipe 1 group, disassembled recipe 2 group, Rhodiola rosea group and Hypericum perforatum group. The diazepam group was intragastrically administered normal saline for the first 3 days, followed by intragastric administration of 5 mg / Kg·d diazepam for the next 4 days; the saline group was intragastrically administered equal-volume normal saline (1ml) for 7 consecutive days; Each unilateral group was given the corresponding drug extract by intragastric administration for 7 consecutive days. Among them, the crude drug content of the drug group is the drug of the present invention with the optimal dose of 10g / Kg d; the first group of disassembled prescriptions is the drug group lacking the main component Rhod...

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Abstract

The invention provides an anxiolytic drug and a preparation method thereof, wherein the anxiolytic drug is prepared by the following raw materials in parts by weight: 5-25 parts of rhodiola rosea, 5-15 parts of hypericum perforatum, 5-15 parts of gastrodia elata, and 5-18 parts of rehmanniae vaporata. The anxiolytic drug has the advantages of reasonable formulation, simplicity in preparation and obvious effect. The animal experiment indicates that the anxiolytic drug can obviously enhance the secretion level of inhibitory neurotransmitter in serum, namely reanal GABA, obviously enhances the anxiolytic action capacity of mice, and has no side effects to affect learning and memory abilities after being taken for a long term.

Description

technical field [0001] The invention relates to a medicine with anti-anxiety effect, in particular to an anti-anxiety medicine prepared from Chinese herbal medicine with the same origin as medicine and food, and also relates to a preparation method of the medicine. Background technique [0002] With the accelerated pace of social work and intensified competitive pressure, the incidence of psychological stress diseases has increased year by year. It is estimated that depression, which ranks fifth among the top ten diseases in the world, will rise to become the second deadly human disease after ischemic heart disease by 2020. [0003] Although great progress has been made in anti-anxiety drugs at present, there is still a lack of ideal drugs. Though some new medicines take effect quickly but long-term use medicine side effect is bigger. For example, more anti-anxiety western medicines such as benzodiazepines, diazepam, etc. are widely used clinically. Long-term use can easil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61P25/22
Inventor 朱伟徐重明沈俊张慧刘秋红
Owner NAVY MEDICINE RES INST OF PLA
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