Portable double-channel transcranial ultrasonic stimulation device for neuromodulation

Abstract

The invention discloses a portable double-channel transcranial ultrasonic stimulation device for neuromodulation. The device is used for outputting an ultrasonic signal matched with an ultrasonic probe and comprises a main control unit, a signal generator unit, a power amplifier unit, a resonant impedance matching unit, a display control panel unit and a power supply system unit; the device comprises a first channel and a second channel which are mutually independent; the first channel comprises a first ultrasonic excitation signal branch and a first external trigger signal branch which are connected with the main control unit; the second channel comprises a second ultrasonic excitation signal branch and a second external trigger signal branch which are connected with the main control unit; the device also comprises an external cooperative unit; and the working mode of the external cooperative unit comprises a synchronous trigger mode and an asynchronous trigger mode. The transcranialultrasonic stimulation device provided by the invention is simple in work integration, flexible in control and rich in function, and can meet the neuromodulation requirements of various stimulation modes.

Description

technical field [0001] The present application relates to the technical field of neuromodulation, in particular to a portable dual-channel transcranial ultrasonic stimulation device for neuromodulation. Background technique [0002] Neuromodulation technology is an important tool for neuroscience research, neural engineering and clinical application. The common neuromodulation methods at this stage include deep brain stimulation (DBS, Deep brain stimulation), transcranial direct current stimulation (tDCS, Transcranial direct current stimulation), Cranial Magnetic Stimulation (TMS, Transcranial magneticstimulation) and Optogenetics (Optogenetics) and Transcranial Ultrasound Stimulation (Transcranial Ultrasound Stimulation, TUS). DBS has micron-level spatial resolution, but its application is limited by surgical trauma and inflexible changes in stimulation targets, and there are risks such as postoperative infection. Although TMS and tDCS have the advantages of being non-inva...

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Problems solved by technology

We found in the literature search that the above-mentioned technologies and devices cannot meet the precise timing control of multi-channel stimulation, have not achieved asynchronous triggering, and are difficult to meet the requirements of real-time closed-loop transcranial ultrasound stimulation in cooperation with other devices (such as EEG or EMG).

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