Wearable mouse brain stimulation ultrasonic transducer

An ultrasonic transducer and wearable technology, used in ultrasonic therapy, sensors, medical science, etc., can solve the problems of small focal area, deep brain tissue can not achieve neural stimulation, can not provide and so on

Inactive Publication Date: 2018-07-24
XIDIAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Low frequency (<1MHz) ultrasound is better because it penetrates the skull effectively, but does not provide a smaller focal area
High-frequency ultrasound can provide a smaller focal area, but the attenuation of high-f...

Method used

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  • Wearable mouse brain stimulation ultrasonic transducer
  • Wearable mouse brain stimulation ultrasonic transducer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Forming: Press the curved PZT piezoelectric sheet to the specified thickness with the ball pressure method, and then cut it according to the specified size;

[0037] Gold-plating: gold-plate the inner and outer layers of the piezoelectric film, and all the electrode interfaces plated to the back;

[0038] Shielding material: a mixture of copper powder and epoxy resin with a volume percentage of 45%, after stirring evenly, vacuumize;

[0039] Assembly: Paste the copper core of the peeled wire to the inner electrode with epoxy resin and dry it; make a microcrystalline ceramic ring with an inner radius of 10mm, buckle the piezoelectric piece upside down in the ring, and fill it with the shielding The material is left to stand until the material is solidified; the outer electrode is connected to the threaded electrode of the SMA interface, and the inner electrode is connected to the central inner electrode of the SMA interface through a wire.

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Abstract

The invention relates to a wearable mouse brain stimulation ultrasonic transducer. The wearable mouse brain stimulation ultrasonic transducer comprises a circulator and a piezoelectric array element;a backing block is embedded in the circulator; the piezoelectric array element is connected with the backing block; the piezoelectric array element includes a piezoelectric material layer; one side surface of the piezoelectric material layer has a concave surface, and the shape of the concave surface matches the outer contour shape of a mouse brain skull; an outer electrode is arranged on the concave surface; an inner electrode is arranged on the other side surface of the piezoelectric material layer; an installation hole for installation of an SMA interface is formed in the backing block; theouter electrode is electrically connected to a threaded electrode of the SAM interface; and the inner electrode is connected to a central electrode of the SAM interface. In the technical scheme, thetransducer can achieve focusing by using the concave surface, a large amount of energy is projected to a small area to achieve nerve stimulation; MRI is the highest monitoring method for biological tissue resolution in the prior art, the mouse brain is small, MRI detection can be performed during ultrasonic stimulation so as to achieve a similar real-time detection effect.

Description

technical field [0001] The invention relates to the field of transducers, in particular to a wearable ultrasonic transducer for brain stimulation of mice. Background technique [0002] Neurostimulation methods provide a powerful tool for the study of brain function, and are especially helpful for neurological and psychiatric treatment research. Electrical, optical, magnetic, and acoustic modulation methods have been used for neural stimulation. Deep brain stimulation (DBS) and optogenetics are classic and effective stimulation methods, but these invasive methods have their drawbacks. Transcranial direct electrical stimulation (tDCS) and transcranial magnetic stimulation (TMS) are widely used non-invasive brain stimulation methods, but they cannot achieve high-resolution stimulation in deep brain tissue. Recent studies have shown that ultrasound, as an effective means of non-invasive neurostimulation, can effectively modulate the neural activity of neurons, rodents, monkeys...

Claims

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Application Information

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IPC IPC(8): A61N7/00A61B5/055
CPCA61N7/00A61B5/055A61B2503/40A61N2007/0026A61N2007/0043
Inventor 费春龙刘治勇夏天立李迪杨银堂
Owner XIDIAN UNIV
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