163results about How to "Improved kinetics" patented technology

This invention is directed to prodrugs that can be activated at the preferred site of action in order to selectively deliver the corresponding therapeutic parent drugs to target cells or to the target site. This invention will therefore primarily but not exclusively relate to tumor cells as target cells. More specifically the prodrugs are compounds of the formula V—(W)_k—(X)_l—A—Z, wherein: V is a specifier; (W)_k—(X)_l—A is an elongated self-elimination spacer system; W and X are each a 1,(4+2n) electronic cascade spacer, being the same or different; A is either a spacer group of formula (Y)_m wherein: Y is a 1,(4+2n) electronic cascade spacer, or a group of formula U being a cyclization elimination spacer; Z is a therapeutic drug; k, l and m are integers from 0 (included) to 5 (included); n is an integer of 0 (included) to 10 (included), with the provisos that: —when A is (Y)_m: k+l+m≧1, and if k+l+m=1; —when A is U: k+l≧1.

The present invention is directed to a contaminant removal agent comprising a polyvalent metal sulfide on the surface of an inert substrate. The substrate can be a layered silicate, such as vermiculite, an aluminosilicate such as montmorillonite, or a nonlayered silicate such as a zeolite. The agent removes mercury from process streams. The ion exchange to deposit the polyvalent metal on the substrate is preferably performed at a pH above the pH_ZPC.

Systems and methods drawn to an electrochemical cell comprising a low temperature ionic liquid comprising positive ions and negative ions and a performance enhancing additive added to the low temperature ionic liquid. The additive dissolves in the ionic liquid to form cations, which are coordinated with one or more negative ions forming ion complexes. The electrochemical cell also includes an air electrode configured to absorb and reduce oxygen. The ion complexes improve oxygen reduction thermodynamics and/or kinetics relative to the ionic liquid without the additive.

The present invention concerns electrode materials capable of redox reactions by electrons and alkaline ions exchange with an electrolyte. The applications are in the field of primary (batteries) or secondary electrochemical generators, super capacitors and light modulating system of the super capacitor type.

The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to modified oligonucleotides which can be applied in method of the invention to prevent the accumulation and/or translation of repeat expanded transcripts in cells.

The present invention relates to a process for the recovery of gallium from Bayer process liquors. Bayer process liquor is obtained from alumina industries and contains 450 g/L Na2O, 80 g/L Al2O3 and 190±20 ppm of gallium. The present invention utilizes an organic and inorganic phase for a two stage separation process to recover gallium with high purity.

The present invention relates to methods and apparatuses for heat treatment of semiconductor films upon thermally susceptible non-conducting substrates at a minimum thermal budget are required, and more particularly, to a polycrystalline silicon thin-film transistors (poly-Si TFTs) and PN diodes on glass substrates for various applications of liquid crystal displays (LCDs), organic light emitting diodes (OLEDs), and solar cells. According to the methods and apparatus of the present invention, the semiconductor films can be heat-treated without damaging the thermally susceptible substrates; e.g., crystallization of amorphous silicon films at the minimum thermal budget acceptable for the use of glass, enhancing kinetics of dopant activation at the minimum thermal budget acceptable for the use of glass.

Embodiments of the present invention are directed to flotation of sulfidic materials following aerating by an oxidizing gas and contacting by a sulfoxy reagent.

The invention relates to a two-stage series pressurization direct-driven centrifugal air compressor of a fuel cell engine. The two-stage series pressurization direct-driven centrifugal air compressor comprises end covers, a spindle, volutes, impellers, a rotor, a stator and a driver. The spindle is supported by a left-end radial supporting air foil bearing, a left-end radial supporting air foil bearing bush, an air foil axial thrust bearing and a right-end radial supporting air foil bearing, wherein the left-end radial supporting air foil bearing and the left-end radial supporting air foil bearing bush are arranged on the left side, and the air foil axial thrust bearing and the right-end radial supporting air foil bearing are arranged on the right side of the spindle. The left-end radial supporting air foil bearing bush is arranged on the outer side of the spindle in a surrounding manner. The left-end radial supporting air foil bearing is fixed to the outer side of the left-end radial supporting air foil bearing bush. The air foil axial thrust bearing is fixed to the outer side of the spindle in a bush form. The right-end radial supporting air foil bearing is fixed to the outer side of the air foil axial thrust bearing. Compared with the prior art, the two-stage series pressurization direct-driven centrifugal air compressor is more suitable for the air inlet pressurization scene of the fuel cell engine with the high oilless air inlet requirement, and the durability and reliability of the air compressor of the fuel cell engine can be improved.

The present invention comprises the nitridization of stainless steel with a gaseous nitrogen compound such as nitrogen gas (N₂), or ammonia (NH₃) at high temperature wherein the reaction pressure is lowered. A base powder with properties similar to those of a martensitic stainless steel is prepared from a molten metal with the subsequent incorporation of selective additives such as cobalt, chromium, boron, copper, vanadium, niobium and mixtures thereof to improve high temperature resistance to scuffing and adhesive wear. The molten mixture is then atomized by water- or air-atomization to yield a base powder which is mixed with nitrogen or ammonia gas at various pressures in a static or fluidized bed to provide a nitrogen alloyed particulate, i.e., a nitrided particulate alloy. The powder is heated in a hot isostatic press under vacuum with argon gas at reduced pressure and later cooled to ambient (room) temperature. A second embodiment of the invention also comprises the use of a wrought iron-based stainless steel or casting as the starting material to be nitrided.

A medium for growing vascular lineage cells is described. The vascular lineage cell growth medium includes an oligosaccharide-based hydrogel and a growth factor that promotes vascularization by vascular lineage cells.

The invention relates to a machine tool comprising frame (1) which has rigid side walls (2, 3) with linear guides (4, 5) on the top; compound slides (6, 11) which is movable and situated in or on the linear guides (4, 5) of the side walls, and which guides a processing unit (14) with a spindle head (15) at a front side so as to move the processing unit (14) vertically; and workpiece holding units (24-28) which are arranged in a gap between the side walls and may include a workbench (28) or a workpiece clamping device. One side wall (3) at the front side is shorter than the other side wall (2) for forming an enlarged access to a working space of the machine tool. The linear guides (4, 5) on the side walls (2, 3) of a machine frame (1) are aligned under an acute angle to a vertical center plane of the machine frame (1).

The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.

A method of microwave synthesis of phosphors includes a microwave furnace having a microwave chamber; providing starting material in the microwave chamber; and subjecting the starting material to microwaves, whereby the starting material is synthesized into phosphors. An insulation package for use in microwave synthesis is disclosed that includes an insulator having an opening therein, wherein the opening is substantially symmetrically disposed in relation to a central axis of the insulator, and wherein the opening is adapted to receive starting material. A susceptor configuration may be positioned within the cavity, wherein the insulator, the cavity, and the susceptor configuration are substantially symmetrically disposed in relation to an axis of rotation of the insulation package. A microwave furnace for continuous microwave synthesis of phosphors is also disclosed.

The present invention relates to agglomerated zeolitic adsorbents based on zeolite X with an Si/Al ratio such that 1.15<Si/AL<1.5, consisting of crystals with a mean diameter of 1.7 mm or less and of an inert binder, at least 90% of the exchangeable cationic sites of the zeolite X being occupied by barium ions. They may be obtained by agglomerating a zeolite X powder having a mean diameter of 1.7 mm or less with a binder, followed by zeolitization of the binder, exchange of the zeolite ions with barium (and potassium) ions and activation of the adsorbents thus exchanged. These adsorbents exhibit, simultaneously, excellent selectivity, reduced mass transfer resistance and excellent mechanical strength and are particularly suitable for the adsorption of the paraxylene contained in C8 aromatic hydrocarbon fractions in liquid phase in processes of the simulated moving bed type and especially for the separation of paraxylene of C8 aromatic hydrocarbon fractions by adsorption, but also for the separation of sugars, polyhydric alcohols, cresols, and substituted toluene isomers.

Precious metal-containing mineral material is subjected to an acidic thiocyanate leach to dissolve the precious metal as a precious metal-thiocyanate complex. A feed of the thiocyanate leach solution may include a large molar ratio of ferric iron to thiocyanate. Precious metal may be removed from pregnant thiocyanate leach solution, such as by transferring precious metal from precious metal-thiocyanate complex to precious metal-cyanide complex and then loading the precious metal-cyanide complex onto an adsorbent material. Remaining cyanide in the thiocyanate leach solution may be converted to thiocyanate for additional leaching of precious metal.