Patterned substrate for constructing in-vitro tumour model

A patterning and constructing technology, applied in the direction of tumor/cancer cells, biochemical equipment and methods, microorganisms, etc., can solve the problems of long cycle, high cost, and inability to exert tissue level, etc., and achieve the effect of simple operation

Inactive Publication Date: 2016-08-24
SUN YAT SEN UNIV
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  • Abstract
  • Description
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Problems solved by technology

The traditional two-dimensional cell culture method based on Petri dish, its culture conditions are very different from the microenvironment in the body, the cultured somatic cells cannot perform normal tissue

Method used

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  • Patterned substrate for constructing in-vitro tumour model
  • Patterned substrate for constructing in-vitro tumour model

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Experimental program
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Embodiment Construction

[0017] like Figure 1-Figure 2 As shown, the patterned substrate for constructing an in vitro tumor model according to the present invention includes a substrate layer 1 and a patterned structure 2 arranged on the substrate layer 1, and the patterned structure 2 is formed on the substrate after being pulled. An in vitro tumor model 3 is formed on the bottom layer 1 . Wherein, the base layer 1 is made of metal sheet or polymer material. When the base layer 1 is made of metal flakes, the metal flakes are titanium alloy flakes or aluminum flakes or steel flakes or other metal flakes. When the base layer 1 is made of a polymer material, the polymer material is polystyrene or polymethyl methacrylate or polyethylene or other polymer materials. Moreover, the area where the patterned structure 2 is located is set as a pattern area where the aqueous solution can adhere, and the area outside the patterned structure 2 is set as a background area where the aqueous solution cannot adhere...

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Abstract

The invention discloses a patterned substrate for constructing an in-vitro tumour model. The patterned substrate comprises a substrate layer and a patterned structure which is arranged on the substrate layer; the patterned structure forms the in-vitro tumour model on the substrate layer after being subjected to pulling treatment. The in-vitro tumour model constructed on the substrate layer can be used for simulating an in-vivo tumour tissue, so that the cell biological behaviours of tumour cells are researched, and the interactions among cells are observed; the in-vitro tumour model can also be used for screening medicaments and observing the effects of an anti-tumour medicament on the tumour cells in the in-vitro tumour model. According to the patterned substrate for constructing the in-vitro tumour model, the in-vitro tumour model which is prepared by a simple method has the characteristics of simple operation, portability, individuation and the like; an important research platform is provided for precision medicine and translational medicine research.

Description

technical field [0001] The invention belongs to the field of on-chip laboratory processing and preparation and biomedicine technology, and in particular relates to a patterned substrate for constructing an in vitro tumor model. Background technique [0002] With the continuous cross-infiltration of medicine, physics, chemistry, biology and other disciplines, new research fields such as translational medicine and precision medicine have emerged. Modern medical research highlights the rapid transformation of basic research results into clinical practice, as well as the characteristics of personalization and portability. In the traditional two-dimensional cell culture method based on Petri dish, the culture conditions are very different from the microenvironment in vivo, and the cultured somatic cells cannot perform normal tissue-level functions, and their lifespan is relatively short. In addition to the high cost, long period, and differences between species and errors in pre...

Claims

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Application Information

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IPC IPC(8): C12N5/09C12N5/077
CPCC12N5/0693C12N2502/1347C12N2535/10
Inventor 孙康杨明亮张超徐悦蒋庆
Owner SUN YAT SEN UNIV
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