Combination of an h3 antagonist/inverse agonist and an appetite suppressant
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SCHERING AG
- Publication Date
- 2009-03-04
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to pharmaceutical compositions comprising a therapeutic combination comprising: one or more H 3 Antagonist / inverse agonist; one or more appetite suppressants selected from CB 1 Antagonists / inverse agonists, sibutramine, phentermine, and topiramat; and optionally one or more HMG-CoA reductase inhibitors. The present invention also relates to medicaments and kits comprising the pharmaceutical compositions of the present invention, and methods of using the pharmaceutical compositions of the present invention to treat obesity, obesity-related disorders, and diabetes. Background technique
[0002] histamine receptor H 1 、H 2 、H 3 and H 4 Has been characterized by its pharmacological behavior. h 1 Receptors are those that mediate responses antagonized by commonly used antihistamines. h 1 Receptors are found, for example, in the ileum, skin and bronchial smooth muscle of humans and other mammals. Most notably H 2 The r...