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Method for simultaneously detecting seven slimming chemical components which are illegally added to traditional Chinese medicine, health food or cosmetics

A health food, illegally added technology, applied in measuring devices, scientific instruments, material separation, etc., to achieve strong qualitative ability, shorten inspection time, and improve work efficiency.

Inactive Publication Date: 2013-01-30
HUNAN INST FOR FOOD & DRUG CONTROL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few reports on the detection of demethylated derivatives of sibutramine. Yang Chunhua et al. used the method of methylating sibutramine metabolites to determine the total amount of sibutramine and its metabolites. Chen Zhi et al. used HPLC. Determination of N,N-bisdesmethylsibutramine in weight-loss health food by single-stage mass spectrometry / ESI-MS

Method used

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  • Method for simultaneously detecting seven slimming chemical components which are illegally added to traditional Chinese medicine, health food or cosmetics
  • Method for simultaneously detecting seven slimming chemical components which are illegally added to traditional Chinese medicine, health food or cosmetics
  • Method for simultaneously detecting seven slimming chemical components which are illegally added to traditional Chinese medicine, health food or cosmetics

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Embodiment 1

[0029] 1 Instruments and reagents

[0030] Quattro Premier XE triple quadrupole liquid-mass spectrometer from Waters in the United States, ESI ionization source; ultra-high performance liquid chromatography from Waters in the United States, quaternary pump, degasser, autosampler, column thermostat and diode array detector.

[0031]Sibutramine hydrochloride, fenfluramine hydrochloride, ephedrine hydrochloride, and phenolphthalein reference substances (all from China National Institutes for Food and Drug Control, batch numbers: 100624-200401; 100073-200002; 171241-200506; 0091-9601); Caffeine reference substance (source: USP REFEREN CESTANDAR, batch number: J1D241); N,N-bisdesmethylsibutramine reference substance (source: LGC, batch number: 991.03.09.01); furosemide reference substance (source: DR., lot number: 00820). Water is ultrapure water, and other reagents are chromatographically pure. Samples: purchased from the market.

[0032] 2 Methods and results

[0033] 2.1 Ch...

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Abstract

The invention relates to a method for simultaneously detecting seven slimming chemical components which are illegally added to traditional Chinese medicine, health food or cosmetics. According to the method, an appropriate mobile phase and a reasonable elution gradient are adopted during liquid-phase separation, so that the slimming components needing to be detected are effectively separated within 12 min, the analysis time of a sample instrument is shortened by 88%, and the work efficiency is greatly increased. Additionally, the advantages of high separation ability of the HPLC (High Performance Liquid Chromatography) technology, high sensitivity and stronger qualitative ability of the mass spectrum and the like are combined, so screening and confirmation can be simultaneously completed during one operation. By using the method disclosed by the invention, the seven chemical components including sibutramine, fenfluramine, phenolphthalein, ephedrine, caffeine, N,N-bi-demethylation sibutramine and furosemide can be effectively separated, the inspection time can be shortened, and the slimming chemical components which are illegally added to the traditional Chinese medicine, the health food or the cosmetics can be accurately and effectively distinguished.

Description

technical field [0001] The invention belongs to the technical field of food and drug detection, and specifically relates to a method for simultaneously detecting seven illegally added weight-loss chemical components in traditional Chinese medicine, health food or cosmetics. Background technique [0002] As people pay more and more attention to healthy weight, weight loss has become the biggest topic of beauty lovers, and various weight loss products are produced accordingly. In order to make their products have a rapid and obvious weight loss effect, some merchants illegally add chemical ingredients that have weight loss effects (such as sibutramine, etc.) At the same time, it will cause harm to the user's health and may even be life-threatening. Therefore, it is urgent to establish a fast and accurate analytical method to detect the weight loss chemical components illegally added in traditional Chinese medicine, health food or cosmetics. [0003] At present, the determina...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 黎银波孟庆玉蒋秋桃殷帅李文莉钟庆元
Owner HUNAN INST FOR FOOD & DRUG CONTROL
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