Anti-releasing compound flexible liposome with positive charges and preparation method thereof

A flexible liposome, positively charged technology, applied in the directions of liposome delivery, medical preparations containing active ingredients, drug combinations, etc. Acting activity, reducing irritation, reducing the effect of content

Inactive Publication Date: 2016-11-09
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because ordinary nanosystems are not specifically positively charged during the production process, it is difficult to adsorb on negatively charged human h

Method used

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  • Anti-releasing compound flexible liposome with positive charges and preparation method thereof
  • Anti-releasing compound flexible liposome with positive charges and preparation method thereof
  • Anti-releasing compound flexible liposome with positive charges and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Anti-hair loss combination, including the following components in parts by weight: 30 parts of linoleic acid, 10 parts of berberine hydrochloride, 15 parts of glycyrrhizic acid, 10 parts of glutathione, 45 parts of phytosphingosine, 20 parts of matrine , 15 parts of tea polyphenols. Dissolve linoleic acid and phytosphingosine in the anti-hair loss composition with 115 parts of absolute ethanol to be ethanol extract, and use 105 parts of water to dissolve berberine hydrochloride, glycyrrhizic acid, glutathione, matrine and tea polyphenols Dissolved as an aqueous extract.

[0061] 180mg stearamide, 220mg cephalin, 200mg cholesterol, 75.0mg anti-hair loss combination alcohol extract were dissolved in 7000mg of chloroform under 35°C water bath condition; 50mg sodium cholate, 70.0mg anti-hair loss combination water extract Dissolve in 200 mg of phosphate buffer solution with pH 7.0 in a water bath; mix the aforementioned phosphate buffer solution with chloroform solution, a...

Embodiment 2

[0064] Anti-hair loss combination, including the following components in parts by weight: 20 parts of linoleic acid, 2 parts of berberine hydrochloride, 5 parts of glycyrrhizic acid, 10 parts of glutathione, 15 parts of phytosphingosine, 10 parts of matrine , 14 parts of tea polyphenols. Dissolve linoleic acid and phytosphingosine in the anti-hair loss composition with 70 parts of absolute ethanol to form alcohol extract, and use 82 parts of water to dissolve berberine hydrochloride, glycyrrhizic acid, glutathione, matrine and tea polyphenols Dissolved as an aqueous extract.

[0065]140mg stearylamide, 160mg soybean lecithin, 150mg cholesterol, 80.0mg alcohol extract of anti-hair loss combination were dissolved in 6000mg chloroform at 35°C in a water bath; 15mg sodium cholate and 120.0mg water extract of anti-hair loss combination were dissolved in Dissolve in 250 mg of phosphate buffer solution with pH 7.0 in a water bath at 35°C; mix the aforementioned phosphate buffer solu...

Embodiment 3

[0068] Anti-hair loss combination, including the following components in parts by weight: 15 parts of linoleic acid, 5 parts of berberine hydrochloride, 8 parts of glycyrrhizic acid, 7 parts of glutathione, 15 parts of phytosphingosine, and 10 parts of matrine , 8 parts of tea polyphenols. Dissolve linoleic acid and phytosphingosine in the anti-hair loss composition with 45 parts of absolute ethanol to form an alcohol extract, and use 57 parts of water to dissolve berberine hydrochloride, glycyrrhizic acid, glutathione, matrine, and tea polyphenols. Dissolved as an aqueous extract.

[0069] Dissolve 80mg of 1,2-dioleoyloxypropyl-N,N,N-trimethylammonium bromide, 120mg of egg yolk lecithin, 100mg of cholesterol, and 60.0mg of the alcohol extract of anti-hair loss combination in a water bath at 35°C In 4000mg chloroform; 25mg sodium cholate, 78mg water extract of anti-hair loss combination, dissolved in 200mg pH7.0 phosphate buffer solution under 35°C water bath; mix the aforeme...

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Abstract

The invention discloses an anti-releasing compound flexible liposome with positive charges and a preparation method thereof. The anti-releasing compound flexible liposome is prepared from the following components in parts by weight: 0.1-10 parts of linoleic acid, 5-30 parts of berberine hydrochloride, 5-30 parts of glycyrrhizic acid, 2-15 parts of glutathione, 0.01-5 parts of phytosphingosine, 1-40 parts of matrine and 1-25 parts of tea polyphenols. By researching a multi-target formula which has a clear mechanism and aims at androgenetic alopecia, an anti-hair loss composition is obtained; and the composition is prepared into the compound liposome with the positive charges, so that the flexible application of the composition on a preparation is improved, and adsorption of the preparation on scalps and deep osmosis of the preparation into hair follicles are promoted. The multi-target compounding effect of the preparation can effectively inhibit further development of hair loss, and the growth of new hairs is promoted.

Description

technical field [0001] The invention relates specifically to a positively charged detachment-preventing composite flexible liposome and a preparation method thereof. Background technique [0002] Androgenetic alopecia (AGA), also known as male pattern alopecia (MPA), is a common and frequently-occurring disease in dermatology, and its etiology is complex. Although the patient had no obvious symptoms, he urgently required treatment because of the impact on the appearance. Studies in recent years have shown that, in addition to congenital genetic factors, the four main targets for androgenetic alopecia include: [0003] 1) Activity of androgen-converting enzyme: androgen (testosterone) is a common hormone circulating in the adult body. For patients with androgenetic alopecia, there is highly active 5α-reductase expression in the hair follicles and around the hair follicles. The enzyme can catalyze the conversion of testosterone into the more active dihydrotestosterone, which...

Claims

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Application Information

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IPC IPC(8): A61K38/06A61K9/127A61P17/14A61K31/201A61K31/4375A61K31/704A61K31/133A61K36/82A61K31/353
CPCA61K38/06A61K9/127A61K9/1277A61K31/133A61K31/201A61K31/353A61K31/4375A61K31/704A61K36/82A61K2300/00
Inventor 吴培诚王卓娅刘彩云罗欣茹廖翠琴
Owner GUANGDONG PHARMA UNIV
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