The invention discloses an arthralgia relief gel paste and a preparation method. The arthralgia relief gel paste comprises the following raw materials in parts by weight: chilli liquid extract, belladonna liquid extract, peppermint oil, methyl salicylate, camphor, diphenhydramine hydrochloride, sodium polyacrylate, sodium carboxymethylcellulose, gelatin, glycerol, aluminium hydroxide, silica, edetate disodium, tartaric acid, polysorbate and purified water. The invention has the advantages of good compatibility, large drug-loading rate, strong moisture retention property, good drug release property, good permeability, strong flexibility, no stimulation to skin, low allergy rate, good pasting property, capability of repeated pasting, safety and environmental protection. In the preparation process of the invention, no gasoline and other organic solvents are used, thereby not only avoiding the loss of volatile components in the traditional Chinese medicine in the production process and ensuring the drug effect, but also avoiding the influence of the organic solvents to the environment.