Arthralgia relief gel paste and preparation method

A gel ointment, joint technology, applied in the direction of non-central analgesics, anti-inflammatory agents, ointment delivery, etc., can solve the problems of backward product technology, poor air permeability, skin irritation, etc., to achieve rapid and effective absorption, good stickability , the effect of improving air permeability

Active Publication Date: 2012-10-31
哈尔滨和心诺泰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the rubber ointment is mixed with rubber, rosin, zinc oxide, lanolin, vaseline and medicinal extract, the products made of this auxiliary material are backward in technology, outdated in technology, and pollute the environment, especially it has poor air permeability and irritates the skin. , Peel off pain, skin residues and other defects, bring pain to patients

Method used

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  • Arthralgia relief gel paste and preparation method
  • Arthralgia relief gel paste and preparation method
  • Arthralgia relief gel paste and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A joint pain relief gel ointment:

[0050] Component Quantity (g)

[0051] Chili Liquid Extract 200

[0052] Belladonna Liquid Extract 200

[0053] peppermint oil 40

[0054] Methyl salicylate 80

[0055] Camphor 200

[0056] Diphenhydramine hydrochloride 13

[0057] Sodium polyacrylate 1000

[0058] Sodium Carboxymethyl Cellulose 120

[0059] Gelatin 240

[0060] Glycerin 4200

[0061] Aluminum hydroxide 5

[0062] Silica 120

[0063] Edetate Disodium 12

[0064] Tartaric acid 90

[0065] Polysorbate 80 30

[0066] Purified water 8450

[0067] Preparation:

[0068] (1) Prepare A, B, C and D components respectively:

[0069] Component A: Add 1000g of glycerin into the first container with a stirrer, turn on the stirrer, add sodium carboxymethylcellulose, and continue to stir until it becomes a translucent colloid;

[0070] Component B: Add 3200g of glycerin into the second container with a stirrer, turn on the stirrer, add aluminum hydroxide and sodium po...

Embodiment 2

[0077] A joint pain relief gel ointment:

[0078] Component Quantity (g)

[0079] Chili Liquid Extract 200

[0080] Belladonna Liquid Extract 200

[0081] peppermint oil 40

[0082] Methyl salicylate 80

[0083] Camphor 200

[0084] Diphenhydramine hydrochloride 13

[0085] Sodium polyacrylate 1350

[0086] Sodium Carboxymethyl Cellulose 120

[0087] Gelatin 200

[0088] Glycerin 4700

[0089] Aluminum hydroxide 10

[0090] Silica 150

[0091] Edetate disodium 7

[0092] Tartaric acid 120

[0093] Polysorbate 60 60

[0094] Purified water 8200

[0095] Preparation:

[0096] (1) Prepare A, B, C and D components respectively:

[0097] Component A: Add 1200g of glycerin into the first container with a stirrer, turn on the stirrer, add sodium carboxymethylcellulose, and continue to stir until it becomes a translucent colloid;

[0098] Component B: Add 3500g of glycerin into the second container with a stirrer, turn on the stirrer, add aluminum hydroxide and sodium...

Embodiment 3

[0105] A joint pain relief gel ointment:

[0106] Component Quantity (g)

[0107] Chili Liquid Extract 200

[0108] Belladonna Liquid Extract 200

[0109] peppermint oil 40

[0110] Methyl salicylate 80

[0111] Camphor 200

[0112] Diphenhydramine hydrochloride 13

[0113] Sodium polyacrylate 1200

[0114] Sodium Carboxymethyl Cellulose 180

[0115] Gelatin 210

[0116] Glycerin 3000

[0117] Aluminum hydroxide 7

[0118] Silica 130

[0119] Edetate Disodium 8

[0120] Tartaric acid 130

[0121] Polysorbate 80 40

[0122] Purified water 6000

[0123] Preparation:

[0124] (1) Prepare A, B, C and D components respectively:

[0125] Component A: Add 1000g of glycerin into the first container with a stirrer, turn on the stirrer, add sodium carboxymethylcellulose, and continue to stir until it becomes a translucent colloid;

[0126] Component B: Add 2000g of glycerin into the second container with a stirrer, turn on the stirrer, add aluminum hydroxide and sodium ...

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Abstract

The invention discloses an arthralgia relief gel paste and a preparation method. The arthralgia relief gel paste comprises the following raw materials in parts by weight: chilli liquid extract, belladonna liquid extract, peppermint oil, methyl salicylate, camphor, diphenhydramine hydrochloride, sodium polyacrylate, sodium carboxymethylcellulose, gelatin, glycerol, aluminium hydroxide, silica, edetate disodium, tartaric acid, polysorbate and purified water. The invention has the advantages of good compatibility, large drug-loading rate, strong moisture retention property, good drug release property, good permeability, strong flexibility, no stimulation to skin, low allergy rate, good pasting property, capability of repeated pasting, safety and environmental protection. In the preparation process of the invention, no gasoline and other organic solvents are used, thereby not only avoiding the loss of volatile components in the traditional Chinese medicine in the production process and ensuring the drug effect, but also avoiding the influence of the organic solvents to the environment.

Description

technical field [0001] The invention relates to a joint analgesic ointment and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations for external use. Background technique [0002] Traditional Chinese medicine is a basic part of my country's excellent traditional culture and a great contribution of the Chinese nation to human culture. It has played a major role in the prosperity and prosperity of the Chinese nation for thousands of years. As an industry with obvious advantages in my country, traditional Chinese medicine has strong international competitiveness. At present, the world's transdermal drug delivery system is developing at an annual growth rate of 15%. [0003] Joint pain relief ointment (rubber ointment) has been deeply loved by patients since it went on the market, and it is widely used clinically. However, since the rubber ointment is mixed with rubber, rosin, zinc oxide, lanolin, vaseline and medicinal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61K9/06A61K47/42A61P19/02A61P29/00A61K31/125A61K31/135A61K31/618
Inventor 山内仁史野口一龙本威
Owner 哈尔滨和心诺泰制药有限公司
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