14 results about "Gut immunity" patented technology

The invention discloses a plant lactobacillus PC037 capable of improving intestinal immunity and a fermented product. The plant lactobacillus PC037 is preserved in the China General Microbiological Culture Collection Center on December 13, 2021, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 24096. The plant lactobacillus PC037 can improve the repair speed of the intestinal mucosa and promote the enhancement of the immunity of the intestinal tract. The plant lactobacillus fermented product capable of improving the immunity of the intestinal tract, provided by the invention, can be used for adjusting the exhaust frequency, promoting the enhancement of the immunity of the intestinal tract and reducing the occurrence frequency of diarrhea caused by pathogenic bacteria infection of travelers in a travel process.

The invention relates to livestock feeding probiotics, in particular to bacillus subtilis and application, the bacillus subtilis is bacillus subtilis BW and is preserved in the China General Microbiological Culture Collection Center on April 10, 2025, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) 0.34165. The bacillus subtilis BW disclosed by the invention can be colonized in animal bodies, so that the diarrhea rate of piglets is remarkably reduced, the immunity of intestinal tracts is improved, and the health of the intestinal tracts is improved; after the bacillus subtilis BW is used for feeding ruminants, the feed conversion efficiency can be remarkably improved, the growth performance can be improved, and the bacillus subtilis BW has a good application prospect in livestock and poultry breeding.

A Bifidobacterium longum subsp. infantis YLGB-1496 bacterial preparation, a preparation method, and a use thereof. The bacterial preparation is prepared by fermentation of a viable bacterium of Bifidobacterium longum subsp. infantis, and is prepared from the viable bacterium of Bifidobacterium longum subsp. infantis and its metabolite of specific composition; and the bacterial preparation is used for intestinal health regulation, has efficacies such as an anti-inflammatory efficacy, enhanced gut immunity, regulation of gut microbiota, and alleviation of intestinal bloating, can be used for the preparation of fermented foods, drugs, or animal feed, and has wide application prospects.

The invention discloses a bifidobacterium longum subsp. Infantis YLGB-1496 microbial agent, a preparation method and intestinal health application of the bifidobacterium longum subsp. Infantis YLGB-1496 microbial agent, and relates to the technical field of probiotics. The live bacterium agent of the bifidobacterium longum subsp. Infantis, provided by the invention, has the effects of resisting inflammation, effectively improving intestinal immunity, regulating intestinal flora and relieving intestinal flatulence, can be used for preparing fermented foods, medicines or feeds, and has a very wide application prospect.

The invention relates to the technical field of biology, in particular to application of osteopontin in regulation of intestinal anaerobic symbiotic bacteria colonization. The osteopontin is used for preparing food or medicine for improving the immunity of the intestinal tract, and the food or medicine is used for improving the abundance of anaerobic symbiotic bacteria in the intestinal tract; according to the application disclosed by the invention, firstly, by virtue of transcriptome analysis, it is proved that the abundance of Parabacteroids distans and Blautiapseudococcoids can be remarkably improved by virtue of the exogenous osteopontin, so that the abundance of the Parabacteroids distans and the abundance of the Blautiapseudococcoids can be remarkably improved; secondly, the invention also proves that the exogenous osteopontin can be used for inhibiting the proliferation of harmful bacteria Escherichia coli; therefore, the intestinal immunity is improved, the intestinal barrier is improved or repaired, and the intestinal flora balance is maintained. The composition is suitable for infants, old people, patients and other people with low immunity.

The present invention relates to a probiotic agent for enhancing intestinal immunity and its application. The strains in the probiotic agent for enhancing intestinal immunity include Lactobacillus rhamnosus LRa66 strain and Bifidobacterium longum subsp. infantis BI03 strain. There are potential interactions between the two strains, which can cooperate with each other and synergistically enhance the efficacy of enhancing intestinal immunity. Specifically, it is reflected in: improving the related symptoms of the diarrhea mouse model; improving the related symptoms of the constipation mouse model; significantly enhancing the immune function of mice. When the amount of bacteria used is the same, compared with the single LRa66 strain or the single BI03 strain, the compounding of the two bacteria significantly improves the above-mentioned efficacy.

This invention relates to a strain of *Lactobacillus plantarum* with accession number 35817 from the China General Microbiological Culture Collection Center (CGMCC), and its application in improving intestinal immune function and promoting human intestinal health. This strain can be used as a probiotic ingredient to prepare compositions with the following functions: enhancing resistance to intestinal bacterial infections, maintaining intestinal barrier function, and regulating inflammatory responses. The compositions can be formulated into foods, beverages, or pharmaceuticals for enhancing intestinal immune function and intestinal health.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

Bacillus strain compositions and methods for converting (i) one or more polysaccharides into short chain polysaccharides and / or monosaccharides and / or (ii) one or more proteins into short chain polypeptides and / or amino acids are provided. The Bacillus strain composition can comprise Bacillus subtilis 750 or an active variant thereof, and optionally at least one of Bacillus subtilis 747, Bacillus subtilis 839, Bacillus subtilis 1781, Bacillus subtilis 1999, Bacillus subtilis 2018, or an active variant thereof. Compositions provided herein can be fed to animals in an effective amount to increase digestibility of one or more polysaccharides and / or one or more proteins; increase nutrition efficiency and / or energy partitioning; increase nutrient absorption; enhance gut immunity and / or gut barrier integrity; and / or inhibit a pathogen in the gastrointestinal tract of the animal.

The invention relates to the field of biological medicine, and discloses a composition targeting a lactobacillus johnsonii-tryptophan metabolic axis and application of the composition. The composition comprises a traditional Chinese medicine extract and lactobacillus johnsonii, the traditional Chinese medicine extract is prepared from radix bupleuri, radix paeoniae alba, fructus aurantii immaturus and honey-fried licorice root. Traditional Chinese medicine extracts of radix bupleuri, radix paeoniae alba, fructus aurantii immaturus and honey-fried licorice root are compounded with lactobacillus johnsonii according to a specific proportion, tryptophan is promoted to be converted into 5-hydroxytryptamine, kynurenine is inhibited from being generated, depression-like behaviors are effectively relieved, the traditional Chinese medicine composition can cooperate with anticancer drugs to remarkably inhibit cancer cell growth, meanwhile, the intestinal barrier function can be improved, the intestinal immunity can be improved, and the curative effect is good. The invention provides a high-safety synergistic treatment scheme with triple effects of tumor inhibition, depression resistance and intestinal tract improvement for patients with liver cancer and depression.

A Bifidobacterium longum subsp. infantis YLGB-1496 bacterial preparation, a preparation method, and a use thereof. The bacterial preparation is prepared by fermentation of a viable bacterium of Bifidobacterium longum subsp. infantis, and is prepared from the viable bacterium of Bifidobacterium longum subsp. infantis and its metabolite of specific composition; and the bacterial preparation is used for intestinal health regulation, has efficacies such as an anti-inflammatory efficacy, enhanced gut immunity, regulation of gut microbiota, and alleviation of intestinal bloating, can be used for the preparation of fermented foods, drugs, or animal feed, and has wide application prospects.

The present invention discloses a plant lactobacillus PC037 and a fermented product for improving intestinal immunity. The plant lactobacillus PC037 was deposited in the General Microbiology Center of the China Culture Collection Administration on December 13, 2021, with a deposit number of CGMCC No. 24096. The plant lactobacillus PC037 can increase the repair speed of the intestinal mucosa and promote the enhancement of intestinal immunity. The plant lactobacillus fermented product for improving intestinal immunity provided by the present invention can regulate the frequency of flatulence, promote the enhancement of intestinal immunity, and reduce the number of diarrhea caused by pathogen infection during travel.

The present invention discloses a method for identifying and selecting the germplasm quality of musk deer suitable for plateau breeding, and belongs to the field of biotechnology and animal breeding technology. The method comprises the following steps: collecting fresh feces of musk deer; extracting fecal hormones and immunoglobulin A; determining the concentrations of fecal hormones and immunoglobulin A; dividing the three physiological and immune parameters into a high-content group, a medium-content group, and a low-content group, and calculating the proportion of each group; selecting musk deer individuals with low sensitivity, high energy metabolism, and high intestinal immunity; and selecting musk deer individuals suitable for plateau breeding. The present invention discloses a method for identifying and selecting the germplasm quality of musk deer suitable for plateau breeding. By adopting a non-invasive fresh feces sampling method to determine the three physiological and immune parameters in musk deer feces, the scientific identification and selection of the germplasm quality of musk deer suitable for plateau breeding is achieved.

The invention discloses a compound prebiotics synergistically fermented functional vinegar drink for regulating intestinal flora. The functional vinegar drink comprises the following raw materials in parts by weight: 50-70 parts of brewed vinegar; a proper amount of water; 5-15 parts of a sweetening agent; 10 to 20 parts of modified fructo-oligosaccharide; 8-15 parts of a fermented soybean meal extract; 5 to 10 parts of a lactobacillus plantarum fermentation product; 2 to 5 parts of a blueberry polyphenol extract; 0.1 to 0.5 part of a stabilizing agent; according to the compound prebiotics disclosed by the invention, through a synergistic fermentation technology, the growth of beneficial bacteria can be more effectively promoted, and the reproduction of harmful bacteria can be inhibited, so that the balance of intestinal flora is regulated, and the health of intestinal tracts is improved; the probiotics and the prebiotics can stimulate intestinal mucosa cells to generate immune globulin and cell factors, so that the immunity of the intestinal tract is improved, and the overall immunity of the body is further enhanced; organic acid and probiotics in the vinegar drink can promote peristalsis of gastrointestinal tracts, accelerate digestion and absorption of food and improve symptoms such as dyspepsia.