A kind of cu/paa composite film and its preparation method and application

A composite membrane and H3PO4 technology is applied in the field of bioactive materials and their preparation, which can solve the problems of difficult bioactive substance loading, effective control, etc., and achieve the effects of simple and efficient preparation method, low cost, and promotion of osteoblast proliferation.

Inactive Publication Date: 2019-05-03
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most surface modification methods are difficult to achieve effective

Method used

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  • A kind of cu/paa composite film and its preparation method and application
  • A kind of cu/paa composite film and its preparation method and application
  • A kind of cu/paa composite film and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) The high-purity aluminum sheet is used as the anode, the graphite plate is used as the counter cathode, and 0.4MC with 40V DC constant voltage at 2°C is used 2 h 2 o 4 2H 2 Carry out two anodic oxidations in O solution, the first anodic oxidation 2h, the second anodic oxidation 3h, obtain PAA;

[0037] (2) Immediately after the secondary anodic oxidation, the step-down step is performed, the drop rate is 1V / 30s, the lower limit of the step-down step is 2V, and the deionized water is rinsed;

[0038] (3) At 45°C, using 5wt% H 3 PO 4 The solution expands the pores of the aluminum oxide film for 55 minutes;

[0039] (4) Prepare CuSO in advance 4 ·5H 2 O concentration is 10.0wt.%, (NH 4 ) 2 SO 4 The concentration is 2.0wt.%, H 3 BO 3A mixed solution with a concentration of 2.5wt.% is used as an electrodeposition solution;

[0040] (5) The PAA obtained in step (3) was washed with deionized water and immediately immersed in the electrodeposition solution, and...

Embodiment 2

[0052] (1) With high-purity aluminum sheet as anode and graphite plate as counter cathode, 0.4MC with 40V DC constant voltage at 0°C 2 h 2 o 4 2H 2 Carry out anodic oxidation twice in O solution, the first anodic oxidation 3h, the second anodic oxidation 3h, obtain PAA;

[0053] (2) Immediately after the secondary anodic oxidation, the step-down step is performed, the drop rate is 2V / 30s, the lower limit of the step-down step is 6V, and the deionized water is rinsed;

[0054] (3) At 45°C, using 5wt% H 3 PO 4 The solution expands the pores of the aluminum oxide film for 65 minutes;

[0055] (4) Prepare CuSO in advance 4 ·5H 2 O concentration is 9.0wt.%, (NH 4 ) 2 SO 4 The concentration is 1.5wt.%, H 3 BO 3 A mixed solution with a concentration of 2.0wt.% is used as an electrodeposition solution;

[0056] (5) The PAA obtained in step (3) was washed with deionized water and immediately immersed in the electrodeposition solution, and the graphite plate was used as the...

Embodiment 3

[0062] (1) With the graphite plate as the cathode and the high-purity aluminum sheet as the anode, at 0°C at 0.4M C 2 h 2 o 4 2H 2 O solution was anodized twice with 40V DC constant voltage, the first anodized for 2h, and the second anodized for 2.5h to obtain PAA;

[0063] (2) Immediately after the secondary anodic oxidation, the step-down step is performed, the drop rate is 2V / 30s, the lower limit of the step-down step is 4V, and the deionized water is rinsed;

[0064] (3) At 45°C, using 5wt% H 3 PO 4 The solution expands the pores of the aluminum oxide film for 60 minutes;

[0065] (4) Preparation of CuSO 4 ·5H 2 O concentration is 8.0wt.%, (NH 4 ) 2 SO 4 The concentration is 1.0wt.%, H 3 BO 3 A mixed solution with a concentration of 2.0wt.% is used as an electrodeposition solution;

[0066] (5) The PAA obtained in step (3) was washed with deionized water and immediately immersed in the electrodeposition solution, and the graphite plate was used as the counter ...

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Abstract

The invention relates to a Cu/porous anodic alumina (PAA) composite membrane as well as a preparation method and application thereof. The composite membrane has a structure that nano-Cu is evenly distributed in a PAA porous structure by means of alternate current (AC) deposition. The preparation method comprises the steps of carrying out barrier layer thinning and pore broadening pretreatment on PAA; adding the PAA subjected to the pretreatment into electro-deposition liquid, and carrying out external AC deposition to obtain the Cu/PAA composite membrane. The method provided by the invention is simple and efficient in operation and convenient to popularize; the prepared composite membrane has antibacterial property and osteoblast adhesion proliferation promoting ability at the same time, thus being expected to come into use as a surface coating of an artificially implanted material.

Description

technical field [0001] The invention belongs to the field of bioactive materials and their preparation, in particular to a Cu / PAA composite membrane, its preparation method and application. Background technique [0002] Porous anodic alumina (PAA) is a typical nanoporous self-assembled material with long-range order. The large-area nanopores whose surfaces are parallel to each other can mimic the size and arrangement of collagen fibers in bone tissue (International Journal of Nanomedicine 2014; 9:3325-3334). Studies have shown that the nanopore array of anodized aluminum can significantly promote the growth of osteoblasts, and cells can firmly attach to its surface (ActaBiomaterialia 2014; 10:968-74). However, the surface of PAA does not have antibacterial activity and is susceptible to bacterial infection. Using the highly regular pore structure on the surface of PAA to load biologically active substances can endow it with multiple biological functions of inhibiting bacte...

Claims

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Application Information

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IPC IPC(8): C25D3/38C25D11/12C25D5/54C25D5/18A61L31/14A61L31/02A61L31/16
CPCA61L31/022A61L31/028A61L31/146A61L31/16A61L2300/102A61L2300/404A61L2300/412C25D3/38C25D5/18C25D5/54C25D11/12
Inventor 倪似愚刘玉昆梅琳
Owner DONGHUA UNIV
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