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A kind of bionic ternary ion-doped hydroxyapatite bioceramic powder material and its preparation method and application

A hydroxyapatite and ion doping technology, which is applied in biomedical materials and chemical fields, can solve the problems of complex material synthesis process, achieve simple operation, low cost, and promote the proliferation and differentiation of osteoblasts

Active Publication Date: 2020-12-11
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese invention patent with the publication number CN104399126A provides the preparation process of carbonate ion-doped hydroxyapatite and polymethyl methacrylate blended nanocomposite material. The synthesis process of the material in the invention is complicated, and it is very easy to introduce impurities

Method used

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  • A kind of bionic ternary ion-doped hydroxyapatite bioceramic powder material and its preparation method and application
  • A kind of bionic ternary ion-doped hydroxyapatite bioceramic powder material and its preparation method and application
  • A kind of bionic ternary ion-doped hydroxyapatite bioceramic powder material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) according to the following chemical formula Ca 10 (PO 4 ) 6 (OH) 2 The stoichiometric ratio of (HAP) accurately weighed 3.7810g Ca (H 2 PO 4 ) 2 ·H 2 O, 2.5932g Ca(OH) 2 , add water and stir evenly;

[0052] (2) Transfer the reaction solution into a polytetrafluoroethylene container. Use a stainless steel container to fix it in a homogeneous reactor with a rotation speed of 15 rpm and a reaction condition of 150°C for 24 hours;

[0053] (3) After the reaction is completed, the wet powder is obtained by suction filtration, and dried to obtain the hydroxyapatite powder Ca 10 (PO 4 ) 6 (OH) 2 ;

[0054] (4) Using a mold with a diameter of 13 mm, press 0.2 g of powder under a pressure of 10 MPa for 1 minute, and sinter at 1000 ° C for three hours to prepare a hydroxyapatite bioceramic bulk material.

Embodiment 2

[0056] (1) according to the following chemical formula Ca 9.995 Zn 0.005 (PO 4 ) 6 (OH) 2 The stoichiometric ratio of (Zn / HAP) accurately weighed 3.7810g Ca(H 2 PO 4 ) 2 ·H 2 O, 2.5915g Ca(OH) 2 , 0.0074g Zn(H 2 PO 4 ) 2 2H 2 O (g) add water and stir well.

[0057] (2) Transfer the reaction solution into a polytetrafluoroethylene container. Use a stainless steel container to fix it in a homogeneous reactor with a rotation speed of 15 rpm and a reaction condition of 150°C for 24 hours;

[0058] (3) After the reaction is completed, the wet powder is obtained by suction filtration, and dried to obtain Zn-doped hydroxyapatite powder Ca 9.995 Zn 0.005 (PO 4 ) 6 (OH) 2 (Zn / HAP);

[0059] (4) Using a mold with a diameter of 13 mm, press 0.2 g of powder at a pressure of 10 MPa for 1 minute, and sinter at 1000 ° C for three hours to prepare a Zn ion-doped hydroxyapatite bioceramic bulk material.

Embodiment 3

[0061] (1) according to the following chemical formula Ca 9.989 Zn 0.005 Sr 0.006 (PO 4 ) 6 (OH) 2 The stoichiometric ratio of (ZnSr / HAP) accurately weighed 3.7810g Ca(H 2 PO 4 ) 2 ·H 2 O, 2.5893g Ca(OH) 2 , 0.0074g Zn(H 2 PO 4 ) 2 2H 2 O(g), 0.0080gSr(OH) 2 ·8H 2 O, add water and stir evenly;

[0062](2) Transfer the reaction solution into a polytetrafluoroethylene container. Use a stainless steel container to fix it in a homogeneous reactor with a rotation speed of 15 rpm and a reaction condition of 150°C for 24 hours;

[0063] (3) After the reaction is completed, the wet powder is obtained by suction filtration, and dried to obtain ZnSr / Ca 9.989 Zn 0.005 Sr 0.006 (PO 4 ) 6 (OH) 2 ;

[0064] (4) Use a mold with a diameter of 13mm to hold 0.2g of powder at a pressure of 10Mpa for 1 minute, and sinter at a temperature of 1000°C for three hours to make Zn ion and Sr ion binary doped doped hydroxyapatite Bioceramic bulk materials.

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Abstract

The invention provides a biomimetic ternary ion-doped hydroxyapatite bioceramic powder material, and a preparation method and an application thereof. The chemical formula of the biomimetic ternary ion-doped hydroxyapatite bioceramic powder material is Ca10-a-bZnaSrb(PO4)6(OH)2-cFc, wherein a is not less than 0.004 and not more than 0.006, b is not less than 0.005 and not more than 0.007, and c isnot less than 0.04 and not more than 0.08. The material promotes biomineralization and osteoblast adhesion, so the material has great application values in the field of hard tissue repairing materials.

Description

technical field [0001] The invention relates to a biomimetic ternary ion-doped hydroxyapatite bioceramic material and a preparation method and application thereof, belonging to the fields of chemistry and biomedical materials. Background technique [0002] Hard tissue implant materials are important biomedical materials for the repair and reconstruction of hard tissue injuries. Due to the influence of diseases, aging, frequent traffic accidents and other factors, the demand for hard tissue implant materials is increasing day by day. Hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 (HAP) is a bioactive material, the main component of human hard tissue, and one of the most widely used hard tissue replacement materials in clinical practice. However, pure hydroxyapatite cannot quickly form a combination with the soft and hard tissues of the human body after being implanted in the human body, thereby inducing the formation of new bone tissue on the surface, so some other factors need t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/626C04B35/622A61L27/12A61L27/10A61L27/54A61L27/50
CPCA61L27/10A61L27/12A61L27/50A61L27/54A61L2300/102A61L2300/106A61L2430/02C04B35/447C04B35/622C04B35/626C04B2235/3208C04B2235/3212C04B2235/3213C04B2235/3284C04B2235/445C04B2235/656
Inventor 祝迎春肖胜杰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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