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Bone defect repairing material, preparation method and applications thereof
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A technology for defect repair and bioceramic materials, applied in the field of bone defect repair materials and its preparation
Active Publication Date: 2015-03-11
SHENZHEN INST OF ADVANCED TECH
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Traditional bone defect repair materials have certain limitations, so it is necessary to develop new bone defect repair materials
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[0034] In addition, this embodiment also provides a method for preparing a bone defect repair material, including the following steps:
[0035] Step 1: Inoculate the cellulose-producing bacteria into the medium and cultivate until a bacterial cellulose film with a thickness of 1-5 mm is obtained, then break the bacterial cells, remove the broken bacterial cells, and collect the bacterial cellulose film.
[0036] For example, you can choose a concentration of 0.80to2.30×10 5 CFU / mL (CFU: Colony Forming Units, number of colonies) Gluconacetobacter strain solution, the strain solution was inoculated into the medium at a ratio of 1:50-100, and cultured statically at 28-32°C . Among them, the composition of the medium is as follows: 0.1-0.4g / mL glucose, 0.03-0.06g / mL peptone, 0.02-0.03g / mL anhydrous disodium hydrogen phosphate, 0.01-0.02g / mL citric acid, 0.005-0.015g / mL magnesium sulfate, 0.005-0.01g / mL ammonium sulfate and 0.005-0.015% volume percentage of corn syrup extract, an...
Embodiment 1
[0046] Step 1: Select a concentration of 0.80to2.30×10 5 CFU / mL Gluconacetobacter strain solution, inoculate the strain solution into the culture medium at a ratio of 1:100, and culture it statically at 30°C. Among them, the composition of the medium is as follows: 0.1-0.4g / mL glucose, 0.03-0.06g / mL peptone, 0.02-0.03g / mL anhydrous disodium hydrogen phosphate, 0.01-0.02g / mL citric acid, 0.005-0.015g / mL magnesium sulfate, 0.005-0.01g / mL ammonium sulfate and 0.005-0.015% volume percentage of corn syrup extract, and the solvent of the culture medium is water. When the thickness of the extracellular cellulose membrane reaches 1-5 mm, use a sodium hydroxide solution with a concentration of 0.1 mol / L to vibrate and crush the bacterial cells in a water bath at 80°C, repeat several times until the bacterial cells are completely crushed, and then use Wash the broken cells and sodium hydroxide with deionized water until the pH of the surface of the bacterial cellulose membrane is close...
Embodiment 2
[0059] Calcium triphosphate was used instead of hydroxyapatite.
[0060] Configured as 3mg / mL calcium triphosphate simulated human body fluid suspension.
[0061] Other steps are with embodiment 1.
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Abstract
The invention relates to a bone defect repairing material. The bone defect repairing material comprises a bacteria cellulose membrane, a biologic ceramic material and cellulase, wherein the biologic ceramic material is deposited on a microfiber surface of the bacteria cellulose membrane, and the cellulase is dispersed in the bacteria cellulose membrane and can degrade the bacteria cellulose membrane. When the bone defect repairing material is implanted into bone defect positions, as osteoblasts are attached on the microfiber surface of the bacteria cellulose membrane for growing and the ceramic material is deposited on the microfiber surface of the bacteria cellulose membrane, the osteoblasts growing on the ceramic material deposited on the microfiber surface are wrapped easily, and an intact bone organization is formed by the osteoblasts combining with collagen generated from the osteoblasts. The cellulose membrane is degraded gradually by the cellulase embedded, leaving no residues. Glucose as a degraded product does no harm to cells, and the glucose can support osteocyte copying and growing as nutrients. Furthermore, the invention also relates to a preparation method for the bone defect repairing material and applications of the bone defect repairing material.
Description
technical field [0001] The invention relates to the field of biomedical active materials, in particular to a bone defect repair material and its preparation method and application. Background technique [0002] Bone defects are usually caused by the loss of part of bone tissue due to injury, disease such as osteoporosis or surgical intervention, resulting in loss of function at the missing part. In a large bone, such as the femur, if the bone defect is 8 mm, the defect usually heals itself. However, if the defect is larger than 8 mm, or even smaller than 8 mm in a small bone such as the phalanx, the bone defect does not heal itself and requires bone material to fill or use bone material to guide the growth of bone tissue and cells at the defect to Repair bone defects. Materials traditionally used to fill bone defects are derived from xenografts, allografts, allografts, and inert biomaterials. The first three filling methods and materials are likely to cause rejection, end...
Claims
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Application Information
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