Method for preparing integrated frame fabrication of cartilage of tissue-engineered bone having function interface

A tissue engineering bone and osteochondral technology, applied in prosthetics, bone implants, medical science, etc., can solve problems such as poor integration of the host interface, defects in the quality of reconstructed tissues, and lack of mechanical functions, achieving high molding accuracy, Simple operation and good repeatability

Inactive Publication Date: 2007-09-12
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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Problems solved by technology

[0008] The present invention aims at the deficiencies in the current tissue engineered osteochondral, that is, defects in the quality of reconstructed tissue, poor integration with the host interface, and lack of corresponding mechanical functions. Regulate and modify it, and then apply the advanced preparation technology of 3D printing rapid prototyping to prepare tissue engineering osteochondral biomimetic integrated scaffold with functional interface

Method used

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Embodiment Construction

[0038] Describe the technology of the present invention in detail in conjunction with embodiment:

[0039] 1. Determine the relevant parameters of the three-dimensional structure of the tissue-engineered osteochondral scaffold based on the ultrastructure of the normal human joint osteochondral composite tissue. The shape limit is a cylinder with a diameter of 5mm and a height of 1cm. The actual anatomical shape can be determined by MRI imaging technology get. Then, the computer-aided design software (CAD) was used to establish the osteochondral composite tissue-integrated scaffold model. The scaffold is composed of cartilage layer, calcification layer and subchondral bone layer from top to bottom. Each layer has different composition and internal space structure, and each layer is closely connected by the special composition and structure of calcification layer. The computer-aided design software (CAD) used in the present invention is a prior art, and those skilled in the art...

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Abstract

The present invention discloses process of preparing integral bionic tissue engineering bone-cartilage rack with functional interface. The process includes the first establishment of CAD model of the integral bone-cartilage rack by means of bionic principle; preparing collagen / chitosan and collagen / hydroxyapatite micro polymer powder; converting the CAD model into fast forming file input into a 3D printing fast forming machine, spreading the powder with one powder spreader, spraying pentanedial adhesive selectively on the spread powder for adhering and eliminating excessive powder to obtain the integral bionic tissue engineering bone-cartilage rack with functional interface. The present invention has excellent biocompatibility, controllable cartilage rack degrading speed and mechanical strength and other advantages.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterial preparation, and relates to a method for preparing a tissue engineering osteochondral scaffold, in particular to a preparation method for a tissue engineering osteochondral bionic integrated scaffold with a functional interface. Background technique [0002] Osteochondral defects in joints caused by trauma or bone disease are common clinically, seriously affect the quality of life of patients, and have become one of the main causes of physical disability. The incidence rate in the United States is 1.5‰~3‰, and in my country it is about 5 to 6 times that of the United States, and it is increasing year by year. There are obvious defects in the existing clinical treatment measures. The conservative treatment and joint debridement can only temporarily relieve the pain, but cannot prevent the development of the disease. defect; allogeneic osteochondral transplantation has the possibility o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/40
Inventor 王富友段小军杨柳戴刚
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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