Medical device applications of nanostructured surfaces

a technology of nanofibers and surfaces, applied in the field of nanotechnology, can solve problems such as endangering and susceptible to damage, and achieve the effects of reducing bio-fouling, increasing fluid flow, and improving surface appearan

Inactive Publication Date: 2005-10-06
NANOSYS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] The embodiments of the current invention comprise various medical devices, such as clamps, valves, intracorporeal or extracorporeal devices (e.g., catheters), temporary or permanent implants, stents, vascular grafts, anastomotic devices, aneurysm repair devices, embolic devices, and implantable devices (e.g., ...

Problems solved by technology

The polymer matrix can protect most of the length of ...

Method used

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  • Medical device applications of nanostructured surfaces
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  • Medical device applications of nanostructured surfaces

Examples

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example 1

[0262] The following non-limiting Example presents data from a study conducted at Boston University that illustrates how the use of nanofiber (e.g., nanowire) surfaces as compared to control (reference) surfaces (e.g., quartz) for bone biotemplating applications helps in faster cell differentiation which can be expected to result in faster bone in-growth.

Osteoblast Culture

[0263] Human fetal osteoblasts, designated hFOB 1.19 (American Type Culture Collection (ATCC), Manassas, Va.), were used for cell adhesion studies. This cell line was obtained from a spontaneous miscarriage and transfected with a temperature-sensitive mutant gene of SV40 large T antigen. The cells were programmed to proliferate at 34° C. and differentiate only when the temperature is raised to 39° C. Cells with passage 10 were used in all experiments. The medium used for growing osteoblasts consisted of 1:1 ratio of DMEM:F12 (Invitrogen Corp.) with 10% fetal bovine serum (Sigma-Aldrich) and 0.3 mg / mL of G418 sul...

example 2

[0272] The following non-limiting Example presents data from a Purdue University study that illustrates how the use of nanofiber (e.g., nanowire) surfaces as compared to current orthopedic implant materials leads to increased select osteoblast adhesion in a competitive cell adhesive environment. Various cells important for orthopedic applications were allowed to interact with: current implant materials (i.e., commercially pure titanium (Ti), Ti6Al4V, and CoCrMo), current implant materials with a bioactive hydroxyapatite (HA) coating (i.e., Ti coated with HA and Ti6Al4V coated with HA), HA used not as a coating but in bulk, and nanowire surfaces. Cells that were allowed to interact with the materials simultaneously to simulate in vivo conditions were: osteoblasts (bone-forming cells), fibroblasts (fibrous, not hard, tissue forming cells), endothelial cells, and smooth muscle cells. Fibroblasts, endothelial cells, and smooth muscle cells are considered competitive cells to osteoblasts...

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Abstract

This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part application of U.S. patent Application Ser. No. 10 / 902,700 filed Jul. 29, 2004, which claims priority to U.S. Provisional Patent Application Ser. No. 60 / 549,711, filed Mar. 2, 2004. This application also claims priority as a continuation-in-part application of U.S. patent application Ser. No. 10 / 828,100, filed Apr. 19, 2004, which is a continuation-in-part of U.S. patent application Ser. No. 10 / 661,381, filed Sep. 12, 2003, which claims priority to U.S. Provisional Patent Application No. 60 / 463,766, filed Apr. 17, 2003; and as a continuation-in-part of U.S. patent application Ser. No. 10 / 833,944, filed Apr. 27, 2004, which claims priority to U.S. Provisional Application Ser. No. 60 / 466,229, filed Apr. 28, 2003; and as a continuation-in-part application of U.S. patent application Ser. No. 10 / 840,794 filed May 5, 2004, which is a continuation-in-part of U.S. patent application Ser. No. 10 / 792,402...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61F2/30A61F2/36A61K47/48A61L27/38A61L27/50D04H3/00
CPCA61F2/30767A61F2/36A61F2/3662A61F2/3676A61F2002/30113A61F2002/30322A61F2002/30827A61F2002/3084A61F2002/3631A61F2230/0006A61F2250/0026A61F2310/00616A61F2310/0097A61F2310/00982A61L27/3821A61L27/3839A61L27/50A61L2400/12B82Y5/00Y10T428/249924A61L2430/02A61K47/6957
Inventor DUBROW, ROBERT S.SLOAN, L. DOUGLASKRONENTHAL, RICHARD L.ALFARO, ARTHUR A.COLLIER, MATTHEW D.ROGERS, ERICA J.GERTNER, MICHAEL E.
Owner NANOSYS INC
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