71 results about "Male sex hormones" patented technology

The invention provides an androgen receptor antagonist for resisting the prostate cancer, relates to a sulfoimidazoledione with substituted groups on two nitrogen atoms, and relates to a use of such the compounds as a medicament for treating the diseases or disorders related to the androgen receptor, such as prostate cancer, alopecia or whelk.

The invention relates to tanshinone compounds in the technical field of medicine and applications thereof. The tanshinone compounds contain tanshinone I, tanshinone IIA, cryptotanshinone and dihydrotanshinone I and the structural formulas are shown as below. The method of the invention uses the tanshinone compounds as the active ingredients of the androgen receptor antagonist; the compounds are used alone or used along with the excipient to prepare oral agents or non-oral agents for curing the diseases related to androgen.

A device for massaging male testicles, includes a control part, a vibration part, a bendable part and wherein all the parts can be attached to a human body after being assembled together so as to massage testicles in a vibration manner. The device is convenient and labor-saving to use; and massaging testicles by utilizing the device can improve sperm and secretion of male sex hormones, thereby promoting physical health.

The invention relates the isosulfocyanate compounds (ISOTHIOCYANATES), in other word, JC-5411 compounds, which can adjust the expression of androgen acceptor gene in cell by suppressing the expression of gene transcription factor SP1, and suppress the abnormal breeding function of prostate gland cell. With the little compound, it can suppress hamster benign hypertrophy of the prostate (BPH), which is induced by suppressed male sex hormone, and the growth of prostate gland cancer cell. The invention provides the new method of effectively preventing and treating the hypertrophy of the prostate and prostate gland cancer. The compound possesses the low side effect, steady chemical biology nature, low cost of manufacture, and broad adaptability.

The invention discloses a method for inducing pseudo milters of gynogenesis spotted maigre and belongs to the technical field of aquatic biology. The pseudo milters of the spotted maigre can be obtained by using male hormone for induction during the breeding process of the gynogenesis spotted maigre, and the male hormone is methyltestosterone. The method is reasonable in design, the methyltestosterone is utilized for induction, induction steps are scientifically and reasonably limited, the finally obtained male rate of the gynogenesis spotted maigre can reach more than 86%, and theoretical and technical guidance is provided for qualitative breeding of the gynogenesis spotted maigre.

The invention discloses a total unsaturated toad lactone, and a preparation method and a use thereof. The preparation method for the total unsaturated toad lactone comprises the following steps: (1), crushing the toad, ultrasonically extracting the crushed toad 3-4 times using ethanol solution, and filtering to remove the dredges to obtain the toad extracting solution; (2), concentrating the toad extracting solution under reduced pressure to obtain pulp as the toad total extract; (3), suspending the toad total extract with water, extracting the suspended toad total extract using dichloromethane, and evaporating under reduced pressure to remove dichloromethane to obtain the dichloromethane part; and (4), dissolving the dichloromethane part with a solvent A and regulating the pH value of the solution to 1-6, stirring and reacting the solution for 1-8 hours at a temperature of 0 DEG C to 100 DEG C, adding water to stop the reaction when at least two compounds of Bu-1, Bu-2, Bu-3, Bu-4 and Bu-5 in the solution are detected, extracting using a solvent B, and evaporating under reduced pressure to remove the solvent B to obtain the total unsaturated toad lactone. The total unsaturated toad lactone disclosed by the invention has the activity of inhibiting male sex hormone dependent form prostate cancer cell multiplication and non-male sex hormone dependent form prostate cancer cell multiplication, and can be used for preparing the medicine for preventing and treating the prostate cancer.

The invention discloses ginseng balance tea capable of improving male functions. The tea is prepared from, by mass, 3-27 parts of ginseng, 7-63 parts of fruits of Chinese wolfberry, 6-54 parts of maca, 5-45 parts of stalwart, 5-45 parts of mulberry and 2-18 parts of red dates. According to the ginseng balance tea capable of improving male functions, ginseng, the fruit of Chinese wolfberry, maca, sealwort, mulberry and red dates are cleaned, dried, sterilized, smashed and then blended and packaged according to a certain ratio, substitutional tea used in a brewing mode is prepared from pure plants and has no toxin or side effect, the effects of warming yang, tonifying the kidney, conserving the essence and reinforcing the kidney are achieved, and the tea has the effects of promoting secretion of male sex hormones, rapidly recovering adult male physical power and energy, effectively resisting fatigue, relieving kidney fatigue, improving the male functions, improving the living quality andthe like.

The invention discloses compounds of Formula (1), pharmaceutically-acceptable salts, methods of making them, pharmaceutical compositions containing them and methods for their use. The compounds are neurokinin-3(NK-3) receptor antagonists and are used in the treatment of diseases such as depression, anxiety, schizophrenia, cognitive disorders, psychoses, obesity, inflammatory diseases, irritable bowel syndrome, inflammatory bowel disorder, emesis, preeclampsia, chronic obstructive pulmonary disease, disorders associated with excessive gonadotrophins and/or androgens including dysmenorrhea, benign prostatic hyperplasia, prostatic cancer and testicular cancer.

The invention belongs to the technical field of biological medicine, relates to an application of CCT020312 as a medicine for treating cancer, and in particular relates to the application of CCT020312as the medicine for treating breast cancer or prostate cancer. The CCT020312 can be used for activating a PERK/eIF2alpha/ATF4 signal path and down-regulating AR expression to inhibit a PI3K/AKT/mTORsignal path, promote G1-phase retardation and cell autophagy of a cell cycle, and induce cell apoptosis to inhibit occurrence and development of the prostate cancer and the breast cancer. The CCT020312 can provide a novel strategy and thought for targeted therapy of refractory tumors dependent on male hormone receptors, and can be applied to medical practice of targeted therapy of the prostate cancer and the breast cancer.

The invention relates to the field of cosmetics, and in particular relates to a facial mask with an acne treating function and a preparation method of the facial mask. According to the invention, acnes are treated from the pathogenesis by utilizing the fact that maca extract can regulate secretion of male sex hormones of the skin. The facial mask is composed of the maca extract and other substrates, wherein the main ingredients of the maca extract are macamides and macaenes which can effectively regulate the hormonal equilibrium of the human body, so that the purpose of treating acnes is achieved.

The invention discloses a 17 beta-hydroxysteroid hydroxylase 3 mutant enzyme, a coding gene and engineering bacteria. The 17 beta-hydroxysteroid hydroxylase 3 mutant enzyme is abbreviated as 17 beta-HSD3<G186R/Y195W>, and an amino acid sequence of the 17 beta-hydroxysteroid hydroxylase 3 mutant enzyme is as shown in SEQ ID NO.1. 17 beta-hydroxysteroid hydroxylase 3 is subjected to molecular modification by adopting a rational design technology, the 17 beta-hydroxysteroid hydroxylase 3 mutant enzyme with improved affinity with a substrate is obtained through methods of homologous modeling, molecular docking, binding energy calculation and the like, the enzyme activity is improved by 1.66 times as compared with the original enzyme activity, and by utilizing the strategy, the catalytic activity of the 17 beta-hydroxysteroid hydroxylase 3 can be obviously improved. The 17 beta-hydroxysteroid hydroxylase 3 mutant enzyme is coded, so that the yield of testosterone is up to 3.95 g/L, and technical support and data reference are provided for large-scale biological preparation of the testosterone which is a male hormone drug.

A tussah monosexual male silk moth cultivation process wherein a biologically active male sex hormone is applied to the sex undifferentiation stage of the tussah grub, and sex mutagenization is performed to generate monosexual male silk moth. The advantages of the invention are wide range of gender transformation and large benefit dosage range.

The invention provides a device used for massaging male testes. The device is composed of a massaging body, an electric vibration source, a control module, a handheld part and the like. The control module and the electric vibration source are installed in the massaging body. The handheld part is held by hands, the electric vibration source is started through the control module, the massaging device is pressed by the hands, and the testes can be massaged in a vibrating mode. Users can adjust pressure of the hands, and therefore the massaging force can be adjusted conveniently. By using the massaging device to massage the testes, secretion of sperms and male sex hormones and health of the testes can be promoted.

The invention provides a natural efficient anti-hair-loss hair restorer. A formula of the natural efficient anti-hair-loss hair restorer comprises cannabidiol crude oil, Morocco nut oil, frankincenseoil, tea tree oil, castor oil, bergamot oil and cannabis oil. Raw materials are weighed according to the formula, the raw materials are put into a mixing kettle to be stirred for 10-15 minutes at thetemperature of 35-39 DEG C to enable the raw materials to be in a homogenate state, still standing is conducted for two hours to obtain the natural efficient anti-hair-loss hair restorer, and bottlingis conducted by using a rubber head dropper tool. The natural efficient anti-hair-loss hair restorer is prepared by taking the cannabidiol crude oil as the main raw material, cannabidiol acts on receptors such as the CB1 receptor, the TRPV1 receptor and the 5-HT1A receptor in a human body, thus the activity of 5-alpha reductase is inhibited advantageously, androgen can be generated after the 5-alpha reductase is controlled to react with and testosterone in the human body, and thus the aim of treating alopecia is fulfilled by reducing the androgen level.

The present disclosure is directed to generally methods and/or compositions for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a pre-menopausal, a peri-menopausal or a post-memopausal patient, comprising the administration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor. The present disclosure is also directed to methods and/or compositions for reducing breast pain. The present disclosure is also directed to method and/or compositions for reducing elasticity and/or decreasing mechano-transduction on the genome of breast cells. The present disclosure is also directed to methods and/or compositions for stabilizing and/or increasing the levels of androgen receptor expression in breast tissue.

The invention relates to the field of medicines and particularly relates to a drug-loading material and composition thereof of a sustained-release preparation, the sustained-release preparation and apreparation method therefor. The composition comprises a liposome group and a matrix group which are independently preserved mutually, wherein the liposome group comprises phospholipid and optional cholesterol; the matrix group comprises a matrix, wherein the matrix comprises one or more selected from fatty acid esters, aqueous gel compounds, fat-soluble sustained-release skeleton matrix compoundsand water-soluble sustained-release skeleton matrix compounds; and a weight ratio of the liposome group to the matrix group is 1: (2 to 200). The sustained-release preparation prepared from the composition can stably release drugs at a set release rate, is high in controllability, can achieve large-dose release and can be suitable for serving as an anal sustained-release suppository, thereby being friendlier to skin and safer in use. The sustained-release preparation is particularly suitable for being applied to male hormone drugs or female hormone drugs.

The invention discloses a hair-care loss-preventing composition and application thereof. The hair-care loss-preventing composition is prepared from the following components in parts by weight: 0.1-10parts of linfa leaves and 0.1-10 parts of walnut. The hair-care loss-preventing composition is obtained through a lot of experiments and researches by an inventor, the linfa leaves and the walnut arecarefully selected, and the optimal proportion of the linfa leaves and the walnut is obtained, so the obtained composition is safe and non-toxic, has the very strong effect of inhibiting the 5Alpha-reductase activity, and is capable of promoting the metabolism of scalp cells, increasing the scalp blood microcirculation, thereby inhibiting the synthesis of special male sex hormone DHT, and effectively treating a alopecia seborrhoeica symptom caused by an androgen source character. Rhizoma anemarrhenae and flos carthami are compounded, and can penetrate into a hair follicle so as to form a screen-type protective film, so the secretion of oil contamination of the hair follicle is controlled, and the loss of the grown hairs is prevented. Especially, the linfa leaves and the walnut are compounded, the hair follicle is conveniently stimulated, the scalp cells are activated, the blood circulation is reinforced, and the regeneration of the hairs is promoted.

A traditional condom is made of a rubber thin film without through holes, is watertight, and takes into consideration the fact that bacteria, viruses and microorganisms are cut off so as to avoid cross infection between both a man and a woman. The traditional condom mainly stops sperms from entering a vagina and a uterus, and accordingly the purpose of active contraception is achieved. The traditional condom also has adverse factors, the completely-closed rubber thin film stops body fluid exchange as well, body fluid includes water, protein capable of achieving a lubrication function, small organic molecules, female hormones and male hormones, and an interaction channel of human body bioelectric currents is also cut off. After the traditional condom is used for a long time, adverse effects can be brought to both the man and the woman. A condom with transparent tiny holes can stop bacteria, viruses and microorganisms, body fluid and human body bioelectricity can be transmitted as well, and therefore human health and sexual life harmony can be promoted.

The invention discloses a hair lotion capable of preventing hair loss. The hair lotion capable of preventing the hair loss adopts green tea extracts for improving blood circulation, accelerating proliferation of human hair follicle hair papilla cells and prolonging a cell cycle so as to accelerate growth of hair. In addition, testosterone can be prevented from being converted into dihydrotestosterone so as to avoid a hair loss problem generated due to excessive male sex hormones. Adenosine disodium triphosphate has a function of improving organism metabolism, and participates in metabolism of in vivo fat, protein, sugar, nucleic acid and nucleotide, and the adenosine disodium triphosphate is also a source of in vivo energy; an effect that green tea extracts accelerate the proliferation of the hair follicle hair papilla cells is assisted in being enhanced, and hair follicles are accelerated to grow; two traditional Chinese medicines, including polygoni multiflori radix and cacumen platycladi, can realize hair growth and hair blackening, and also can accelerate local blood circulation, enhance a hair follicle metabolism function and remove dandruff and also can accelerate regeneration of the hair, and the polygoni multiflori radix and the cacumen platycladi contain a small quantity of element copper, growth of scalp hair follicles can be accelerated, and the hair can grow to be thick. The invention also discloses a preparation method of the hair lotion, the method is simple, and the product is stable.

The invention discloses a traditional Chinese medicinal anti-hair loss and hair growth liquid composition for men. The traditional Chinese medicinal anti-hair loss and hair growth liquid composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 100-120 parts of white peony roots, 80-100 parts of semen cuscutae, 100-120 parts of moutan bark, 100-120 parts of red peony roots, 160-180 parts of rosemary leaves, 120-140 parts of melon leaves, 140-160 parts of poria with hostwood and 180-200 parts of mint leaves. The components are mixed by using 60% ethyl alcohol at the ratio of traditional Chinese medicines to the ethyl alcohol of 1:5, and are soaked at a room temperature for 5d; and a soak solution is filtered through a 200mesh stainless steel screen and then mixed to prepare a traditional Chinese medicinal anti-hair loss and hair growth liquid for the men. According to the traditional Chinese medicinal anti-hair loss and hair growth liquid for the men, the cutaneous penetration efficiency is improved through cooperation of inhibition 5-alpha-reductase and a plant penetration enhancer, the dihydrotestosterone level is reduced, the damage of male sex hormone to hair follicles is blocked, pathological cells are repaired, and meanwhile, oil secretion is balanced, the problems such as greasy hair, pruritus capitis and abnormal loss can be quickly solved and normal growth of the hair can be gradually restored.

The invention discloses a carob blood orange potion capable of regulating internal secretion and a preparation method thereof, and belongs to the technical field of health-care drinks. The carob blood orange potion comprises the following components in percentage: 50-55 percent of erythritol, 18-21 percent of isomaltitol, 15-17 percent of grapefruit juice powder, 4-6 percent of carob bean extract, 1.8-2.5 percent of anhydrous citric acid, 1.5-2.5 percent of red beet powder, 1.2-1.5 percent of vitamin C, 0.6-1 percent of instant green tea powder, 0.5-1 percent of blood orange powder, 0.5-1 percent of sour cherry concentrated powder, 0.35-0.5 percent of German chamomile flower extract, 0.35-0.5 percent of roselle powder and 0.15-0.23 percent of sucralose. According to the carob blood orange potion capable of regulating the internal secretion, the internal secretion of a female body is effectively regulated and the concentration of male hormones in blood is reduced through mutual cooperation and common coordination of substances, so that the balance of hormones in the body is maintained, the physiological cycle of the female is favorably improved, and the carob blood orange potion also has the effects of beautifying, whitening, soothing the nerves and regulating sleep.

The invention relates to the technical field of health maintenance equipment, in particular to a prostate therapeutic apparatus. In the prior art, there are no healthcare massaging devices for the parts such as the chung chi, perineum and Huantiao acupoint of a man, therefore the novel prostate therapeutic apparatus is provided. The prostate therapeutic apparatus comprises a front part in a wholeinverted triangle shape and a back part in a whole inverted triangle shape, elastic binding belts are fixed to the back part, and the front part is fixedly connected with the back part detachably through hook and loop fasteners on the binding belts; a connection belt is fixed to the lower end of the back part, the bottoms of the front part and the back part are fixedly connected detachably througha hook and loop fastener, and a front pocket is fixed to the inner surface of the front part; a back pocket is fixed to the inner surface of the back part, and the front part or back part is composedof an outer surface layer, an inner protection layer, a heating layer, an outer protection layer and a waterproof breathable layer in sequence from the outside to the inside. The prostate therapeuticapparatus promotes blood circulation and male sex hormone secretion, achieves an effect of adjusting the physiological function and the reproductive function, and has a wide application prospect in the technical field of healthcare equipment.

The invention provides a composition for controlling oil and preventing hair loss. The composition is prepared from fructus lycii, fructus ligustri lucidi, fructus tribuli and lotus seeds. The composition further comprises one or more of carthamin yellow, emodin and gingerol. The carthamin yellow can promote blood circulation and improve the hair follicle environment; the composition comprises carthamin yellow, emodin and gingerol, the carthamin yellow can inhibit 5 alpha-reductase and excessive secretion of male hormone, the gingerol can resist bacteria and diminish inflammation, inhibit dandruff growth and prevent alopecia/hair growth, and when the content of the carthamin yellow in the composition is 1-10%, the content of the emodin is 0.05-0.3% and the content of the gingerol is 0.2-3%, the content of the carthamin yellow in the composition is 0.05-0.3%, and the content of the gingerol in the composition is 0.05-0.3%. The composition for controlling oil and preventing alopecia can reduce the concentration of dihydrotestosterone, eliminate cell inflammation, regulate the resting period of hair follicles, control oil, prevent alopecia, promote growth, promote scalp blood microcirculation, improve the hair follicle environment, nourish hair roots and improve the allergic reaction of independent substances to the skin by reducing the concentration of dihydrotestosterone. The oil control, hair loss prevention and hair growth effects are jointly and synergistically completed through the composition in a specific proportion.

The invention relates to a non-steroidal male sex hormone receptor modulator or the receivable slat thereof in pharmacy, in particular to a compound for preparing non-steroidal drugs used for preventing and/or curing the partial androgen deficiency in aging males, osteoporosis, myophagism, female sexual insufficiency, anorexia, female polytrichia, severe androgen-dependent type alopecia, acne, cachexia, benign prostatic hyperplasia, prostatic cancer, breast cancer, alzheimer disease, parkinsonism syndrome, etc. The invention also relates to a drug combination containing a general formula I compound or an acceptable salt thereof in pharmacy, and the use of the drug combination containing the general formula I compound or the acceptable salt in pharmacy for preparing drugs to cure the above symptoms or diseases.