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Composition for treating acne and use thereof

A composition and acne technology, applied in the direction of drug combinations, molecular sieves and base exchange compounds, medical preparations containing active ingredients, etc., can solve the problems of drug resistance, unacceptable by patients, toxic and side effects, etc., and achieve the goal of inhibiting expression and reducing The effect of improving the swelling phenomenon of acne

Active Publication Date: 2017-05-31
瑞康东方医学研究(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of method has a certain curative effect, it has the disadvantages of drug resistance and side effects, and most patients are not easy to accept it.

Method used

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  • Composition for treating acne and use thereof
  • Composition for treating acne and use thereof
  • Composition for treating acne and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, the preparation of modified P type zeolite powder

[0025] S1. Preparation of P-type zeolite: Weigh zeolite with an average particle size of 0.8 μm, add hydrochloric acid solution with a mass fraction of 12% according to a liquid-solid ratio of 2:1, stir magnetically, and treat at a constant temperature of 90°C for 2 hours, then wash and filter , dry; take the above zeolite, add NaOH solution, sodium aluminate solution and water, stir magnetically to make the reactants mix evenly; raise the temperature to 100°C, crystallize by hydrothermal reaction for 6h, filter, wash until the pH value is 9, and dry , to obtain P-type zeolite, wherein the weight ratio of the zeolite, NaOH solution, sodium aluminate solution and water is 3:1:1:30;

[0026] S2. Modification: wash the above-mentioned P-type zeolite with deionized water, remove the soluble inorganic matter on the surface of the P-type zeolite, dry, calcinate at a temperature of 550°C for 2 hours, and cool; ...

Embodiment 2

[0027] Embodiment 2, pharmaceutical raw material formula and consumption of the present invention

[0028] Composition 1: 15g of thistle, 10g of Hedyotis diffusa, 15g of honeysuckle, 12g of dandelion, 12g of Patrinia, 6g of Bamboo root and 4g of modified P-type zeolite powder.

[0029] Composition 2: 10 g of thistle, 3 g of Hedyotis diffusa, 10 g of honeysuckle, 9 g of dandelion, 9 g of Patrinia, 3 g of Bamboo root and 2 g of modified P-type zeolite powder.

[0030] Composition 3: 20g of thistle, 12g of Hedyotis diffusa, 20g of honeysuckle, 15g of dandelion, 15g of Patrinia, 9g of dandelion root and 6g of modified P-type zeolite powder.

[0031] Composition 4: 15g of large thistle, 10g of Hedyotis diffusa, 15g of honeysuckle, 12g of dandelion, 12g of Patrinia, 6g of Bamboo root and 6g of P-type zeolite powder.

[0032] Composition 5: 15g of large thistle, 10g of Hedyotis diffusa, 15g of honeysuckle, 12g of dandelion, 12g of Patrinia, and 6g of Phyllostachys edulis.

Embodiment 3

[0033] Embodiment 3, anti-acne effect and test

[0034] 1. Establishment of acne model

[0035] 1.1 Culture of Propionibacterium acnes

[0036] The strains were directly inoculated on the culture medium of Clostridium sporogenes, cultured at 37°C for 24-48h and then observed. Use normal saline to adjust the concentration of P. acnes to 6×10 8 / ml.

[0037] 1.2 Establishment of acne model

[0038] Rabbits were taken, and coal tar solution was applied to the opening of the ear canal on the medial surface of each rabbit’s left ear about 2cm*2cm by the Kligman method once a day, 0.5-1ml each time, for 14 days in a row, and the rabbit ear was injected intradermally on the 4th day Propionibacterium acnes 200μl was injected every other day, and the right ear was not treated, and the model was successfully established 2 weeks later.

[0039] 1.3 Experimental grouping

[0040] The 49 rabbits (male) successfully modeled were randomly divided into 7 groups: model group, positive ...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and specifically relates to a composition for treating acne and use thereof. The composition is prepared from the following components in parts by weight: 10-20 parts of Japanese thistle herbor root, 3-12 parts of spreading hedyotis herb, 10-20 parts of honeysuckle flower, 9-15 parts of Mongolian dandelion herb, 9-15 parts of dahurian patrinia herb, and 3-9 parts of rhizome of henon bamboo shoot. The medicine can significantly ameliorate swelling of rabbit's acne, inhibit expression of inflammatory factors IL-1a and TNF-a, and reduce the effect of male sex hormone dihydrotestosterone, and has the advantages of no drug resistance and no side effect when compared to hormonotherapy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a composition for treating acne and its application. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous glands, mainly due to the increased secretion of androgen during puberty, which stimulates the sebaceous glands of the target organ, resulting in strong sebum secretion, enlarged sebaceous glands, hyperkeratosis of the pilosebaceous gland ducts, and sebum accumulation in the hair follicles to form angle plugs. The mouth is blocked, and Propionibacterium acnes proliferates in large numbers, leading to local inflammation. [0003] Recent studies have shown that testosterone in the skin is converted into more potent dihydrotestosterone (DHT) under the action of 5α-reductase. DHT is the main cause of sebum hyperplasia. It can bind to receptors in sebocytes and stimulate sebaceous glands. Cell proliferation and secr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P17/10C01B39/02A61K33/06
CPCA61K9/0014A61K33/06A61K36/28A61K36/288A61K36/355A61K36/748A61K36/84A61K36/899C01B39/02C01B39/026A61K2300/00
Inventor 郭姣
Owner 瑞康东方医学研究(北京)有限公司
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