Use of natural or artificial isorhodanate analog compound JC-5411 in preparing transcription factor SP1 inhibitor

A technology of JC-5411, ester compounds, applied in the field of medical applications, can solve problems such as uncertainty of curative effect, and achieve the effects of low production cost, inhibition of abnormal proliferation, and wide applicability
CN1769268AInactive Publication Date: 2006-05-10JC (WUXI) CO INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JC (WUXI) CO INC
Publication Date
2006-05-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates the isosulfocyanate compounds (ISOTHIOCYANATES), in other word, JC-5411 compounds, which can adjust the expression of androgen acceptor gene in cell by suppressing the expression of gene transcription factor SP1, and suppress the abnormal breeding function of prostate gland cell. With the little compound, it can suppress hamster benign hypertrophy of the prostate (BPH), which is induced by suppressed male sex hormone, and the growth of prostate gland cancer cell. The invention provides the new method of effectively preventing and treating the hypertrophy of the prostate and prostate gland cancer. The compound possesses the low side effect, steady chemical biology nature, low cost of manufacture, and broad adaptability.
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Description

technical field

[0001] The invention belongs to the field of medical applications, and relates to JC-5411 series compounds, which use isothiocyanate as the core structure, including natural and artificially synthesized isothiocyanates. This invention uses the latest molecular biology technology to prove for the first time that JC-5411 series compounds can regulate the expression of androgen receptor gene in cells and inhibit the abnormal proliferation of prostate cells. Rat benign prostatic enlargement (BPH), and growth of prostate cancer cells. Furthermore, the present invention provides a brand-new method for preventing and treating prostatic enlargement and prostate cancer that is effective. The series of compounds also have the advantages of low toxic and side effects, stable chemical and biological properties, low production cost, etc., and have wide applicability. Background technique

[0002] BPH, also known as benign prostatic enlargement (BPH), and prostate cancer...

Claims

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