Alkylsulphonamide quinolines

An alkyl and amide technology, applied in the field of quinoline derivatives, can solve problems such as limited evaluation
CN101370782AInactive Publication Date: 2009-02-18ASTRAZENECA AB
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ASTRAZENECA AB
Publication Date
2009-02-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses compounds of Formula (1), pharmaceutically-acceptable salts, methods of making them, pharmaceutical compositions containing them and methods for their use. The compounds are neurokinin-3(NK-3) receptor antagonists and are used in the treatment of diseases such as depression, anxiety, schizophrenia, cognitive disorders, psychoses, obesity, inflammatory diseases, irritable bowel syndrome, inflammatory bowel disorder, emesis, preeclampsia, chronic obstructive pulmonary disease, disorders associated with excessive gonadotrophins and / or androgens including dysmenorrhea, benign prostatic hyperplasia, prostatic cancer and testicular cancer.
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Description

technical field

[0001] The present invention relates to quinoline derivatives, pharmaceutical compositions comprising them and the use of these compounds in the treatment of central nervous system and peripheral diseases or disorders. The invention also relates to the use of these compounds in combination with one or more other CNS drugs to enhance the effects of the other CNS drugs. The compounds of the invention are also useful as probes for localization of cell surface receptors. Background technique

[0002] Tachykinin receptors are the targets of a class of structurally related peptides including substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), collectively referred to as "tachykinins". Tachykinins are synthesized in the central nervous system (CNS) as well as in peripheral tissues, and exert various biological activities in the CNS and peripheral tissues. Three tachykinin receptors are known, named neurokinin-1 (NK-1) receptor, neurokinin-2 (NK-2) recepto...

Claims

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