Acne-removing suspension oil essence and preparation method thereof

Abstract

The invention provides an acne-removing suspension oil essence and a preparation method thereof. The acne-removing suspension oil essence comprises a water phase and oil phase particles dispersed in the water phase, the oil phase comprises grease, salicylic acid and an oil-soluble acne-removing component; the water phase comprises a thickening agent, a humectant, a water-soluble acne-removing component and water. Compared with a single water type acne-removing essence, the acne-removing suspension oil essence provided by the invention has the advantages that through the matching of the salicylic acid, the oil-soluble acne-removing component and the water-soluble acne-removing component, the acne-removing effect is more efficient, the oil phase of the product can suspend in the water phase, and the coexistence of the oil phase and the water phase is realized under the condition of not adding an emulsifier, so that the oil-water suspension oil essence has a good application prospect. Irritation caused by an emulsifier is reduced, and the acne cream is friendly to acne skin, especially sensitive acne skin.

Description

Technical Field

[0001] The invention belongs to the technical field of daily cosmetics, and particularly relates to an anti-acne suspension oil essence and a preparation method thereof. Background Art

[0002] Acne, also known as pimples, is a chronic inflammatory disease of the hair follicle sebaceous gland unit, with clinical manifestations of acne, papules, nodules, cysts and even scars. Currently, the products for acne removal on the market are mainly water-based, essence, lotion and other products. Water-based and essence products achieve acne removal by adding exfoliants such as salicylic acid, broad-spectrum antibacterial agents such as pyonine, and Chinese herbal animal and plant extracts to the water phase; lotion products can achieve acne removal by adding oil-soluble acne-removing ingredients such as capryloyl salicylic acid and peony seed oil.

[0003] CN115919679A discloses a microemulsion pre-concentrated composition for inhibiting bacteria and removing acne, promoting wound healing, and fading acne marks, and its preparation method and application, including the following components: an effective ingredient, an emulsifier, an emulsifier and an auxiliary ingredient; wherein the effective ingredient is a composition of ascorbyl tetraisopalmitate, paeonol, capryloyl salicylic acid, peony seed oil, and oat kernel extract. The effective ingredients are all oil-soluble acne-removing ingredients, which have stronger penetration performance than water-soluble ingredients, have the characteristics of taking effect at a lower concentration, and have higher mild performance and stability. The composition has the effects of inhibiting the growth and reproduction of harmful acne-causing bacteria, promoting wound healing, accelerating skin renewal, accelerating the fading of acne marks, reducing pigmentation or accelerating pigment metabolism, repairing and strengthening the skin barrier, and solving the problem that efficacy and mildness cannot be taken into account at the same time.

[0004] CN116712382A discloses an anti-acne essence and a preparation method thereof. The components thereof include: animal and plant extracts, plant essential oils, salicylic acid, a moisturizer, and a stabilizer, wherein the animal and plant extracts include a Bombyx batryticatus extract, a Zanthoxylum fruit extract, and a Camellia oleifera extract, and the plant essential oils include a patchouli oil and a lavender oil. The composition disclosed in the present invention can cooperate with each other to inhibit the growth of Propionibacterium acnes, reduce the probability of acne occurrence, and has a significant anti-acne effect.

[0005] However, the above-mentioned acne removal products can easily cause skin tightness and dryness, and have certain irritation to the skin. Therefore, there is an urgent need to provide a product that is mild, non-irritating and has better acne removal effect to meet people's needs. Summary of the invention

[0006] In view of the deficiencies in the prior art, the object of the present invention is to provide an anti-acne oil suspension essence and a preparation method thereof.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides an anti-acne suspended oil essence, and the anti-acne suspended oil essence comprises an aqueous phase and oil phase particles dispersed in the aqueous phase;

[0009] The oil phase comprises an oil, salicylic acid, and an oil-soluble anti-acne ingredient;

[0010] The aqueous phase comprises a thickening agent, a humectant, a water-soluble anti-acne ingredient, and water.

[0011] The anti-acne suspended oil essence provided by the present invention, through the cooperation of salicylic acid, an oil-soluble anti-acne ingredient, and a water-soluble anti-acne ingredient, not only enables the product to have an excellent antibacterial and anti-acne effect, but also the oil phase of the product can be suspended in the aqueous phase, realizing the coexistence of the oil phase and the aqueous phase without adding an emulsifier, reducing the irritation caused by the emulsifier, and being friendly to acne-prone skin, especially sensitive acne-prone skin.

[0012] In addition, the product of the present invention dissolves salicylic acid in the oil phase and then suspends it in the aqueous phase, solving the problem that salicylic acid is prone to precipitate in the aqueous phase. The product will not cause irritation due to the complete exposure of salicylic acid on the skin after the water evaporates when it comes into contact with the skin. Moreover, the product of the present invention has a wider selection range for the aqueous phase thickening agent, and can greatly reduce the dosage of the thickening agent, so that the skin feel after use by consumers is fresh and non-greasy.

[0013] Preferably, the anti-acne suspended oil essence comprises 1-15 parts by weight of the oil phase and 85-99 parts by weight of the aqueous phase.

[0014] In the anti-acne suspended oil essence of the present invention, the addition amount of the oil phase can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, or 14 parts, etc.;

[0015] The addition amount of the aqueous phase can be 86 parts, 87 parts, 88 parts, 89 parts, 90 parts, 91 parts, 92 parts, 93 parts, 94 parts, 95 parts, 96 parts, 97 parts, or 98 parts, etc.

[0016] Preferably, the oil phase comprises 1-13 parts by weight of an oil, 0.1-2 parts by weight of salicylic acid, and 0.01-3 parts by weight of an oil-soluble anti-acne ingredient.

[0017] Among them, the addition amount of the oil can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, or 11 parts, etc.;

[0018] The addition amount of the salicylic acid can be 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, or 1.8 parts, etc.;

[0019] The addition amount of the oil-soluble acne-removing component can be 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, etc.

[0020] Preferably, the aqueous phase contains, by weight parts, 0.01-1 part of a thickener, 0.1-10 parts of a humectant, 0.01-10 parts of a water-soluble acne-removing component, and 75-99 parts of water.

[0021] Among them, the addition amount of the thickener can be 0.03 part, 0.05 part, 0.08 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, etc.;

[0022] The addition amount of the humectant can be 0.2 part, 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, etc.;

[0023] The addition amount of the water-soluble acne-removing component can be 0.02 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, etc.;

[0024] The addition amount of the water can be 76 parts, 78 parts, 80 parts, 82 parts, 84 parts, 86 parts, 88 parts, 90 parts, 92 parts, 94 parts, 96 parts, 98 parts, etc.

[0025] Specific point values within the above numerical ranges can all be selected, and will not be elaborated one by one here.

[0026] Preferably, the oil includes any one or a combination of at least two of PPG-14 butyl ether, propylene glycol dibenzoate, isononyl isononanoate, glyceryl tri(ethylhexanoate), caprylic / capric triglyceride, C12-15 alkyl benzoate, isopropyl myristate, isopropyl myristate, isopropyl isostearate, ethylhexyl palmitate, ethylhexyl stearate, isostearyl glyceride, olive fruit oil, sunflower seed oil, jojoba seed oil, grape seed oil, macadamia seed oil, squalane, hydrogenated polyisobutene, dicaprylyl carbonate, or dipropylene glycol dibenzoate.

[0027] Preferably, the oil is a combination of PPG-14 butyl ether, propylene glycol dibenzoate, and C12-15 alkyl benzoate.

[0028] In the oil of the present invention, PPG-14 butyl ether can help salicylic acid dissolve in other oils, so that salicylic acid is stabilized in the oil phase without precipitation. The compounding of propylene glycol dibenzoate and C12-15 alkyl benzoate can make the oil beads stably suspended in the aqueous phase. The three cooperate synergistically, and the performance of the finally obtained acne-removing oil-in-suspension essence can be more stable.

[0029] Preferably, the mass ratio of PPG-14 butyl ether, propylene glycol dibenzoate and C12-15 alcohol benzoate is (1.5-3):(1-2):(1-2).

[0030] Wherein "1.5-3" can be 1.6, 1.8, 2, 2.2, 2.4, 2.6 or 2.8, etc.;

[0031] "1-2" can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.;

[0032] “1-2” can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.

[0033] Any specific point value within the above numerical range can be selected, and will not be described in detail here.

[0034] Preferably, the oil-soluble anti-acne ingredient includes any one of capryloyl salicylic acid, cymene, peony seed oil, tea tree essential oil, ylang-ylang flower oil, melaleuca alternifolia leaf oil, bisabolol, ginger root extract, stearyl glycyrrhizinate, lithospermum root extract or lavender oil, or a combination of at least two thereof.

[0035] Preferably, the oil-soluble anti-acne ingredient is a combination of capryloyl salicylic acid and bisabolol;

[0036] Preferably, the mass ratio of the capryloylsalicylic acid to bisabolol is (0.2-0.5):(0.1-0.2).

[0037] Wherein, “0.2-0.5” can be 0.25, 0.3, 0.35, 0.4 or 0.45, etc.;

[0038] “0.1-0.2” can mean 0.12, 0.14, 0.16 or 0.18, etc.

[0039] Any specific point value within the above numerical range can be selected, and will not be described in detail here.

[0040] Preferably, the thickener includes any one of sphingomonas fermentation product extract, carbomer, xanthan gum, gellan gum, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer, sodium polyacryloyldimethyl taurate, polyacrylate crosspolymer-6 or any one of polyacryloyldimethyl taurate or a combination of at least two thereof.

[0041] Preferably, the humectant includes any one or a combination of at least two of glycerin, butylene glycol, dipropylene glycol, sodium hyaluronate, allantoin, trehalose, polyglycerol, maltitol, betaine, glucose, glucosylglycerol or panthenol.

[0042] Preferably, the water-soluble acne-removing ingredient includes any one or a combination of at least two of fruit acid, dipotassium glycyrrhizinate, purslane extract, phellodendron bark extract, sophora flavescens extract, scutellaria extract, bombyx batryticatus extract, zanthoxylum fruit extract, peony root extract, centella asiatica extract, guaiac wood extract, olive leaf extract, witch hazel extract, tea extract, persicogenol, atractylodes root extract, quaternary ammonium salt-73, picrorhiza kurrooa extract, lonicera confusa flower extract, salvia miltiorrhiza root extract, moringa seed extract, norway spruce leaf extract, mango leaf extract, aspalathus linearis extract, ophiopogon japonicus root extract, PCA zinc, cordia myxa fruit extract, bixa orellana seed extract, filtrate of pichia pastoris fermentation lysate, ginsenoside CK, hydrolyzed royal jelly protein, citrus fruit extract or bordeaux tree leaf extract.

[0043] Preferably, the water-soluble acne-removing ingredient is a combination of purslane extract, bordeaux tree leaf extract and hydrolyzed royal jelly protein;

[0044] Preferably, the mass ratio of the purslane extract, bordeaux tree leaf extract and hydrolyzed royal jelly protein is (1-5):(0.5-2):(0.5-2).

[0045] Among them, "1-5" can be 1.5, 2, 2.5, 3, 3.5, 4, 4.5, etc.;

[0046] "0.5-2" can be 0.6, 0.8, 1, 1.2, 1.4, 1.6, 1.8, etc.;

[0047] "0.5-2" can be 0.6, 0.8, 1, 1.2, 1.4, 1.6, 1.8, etc.

[0048] Specific point values within the above numerical ranges can all be selected and will not be elaborated one by one here.

[0049] Preferably, the aqueous phase further includes any one or a combination of at least two of a preservative, a pH regulator or a fragrance;

[0050] Preferably, the preservative includes any one or a combination of at least two of p-hydroxyacetophenone, phenoxyethanol, 1,2-hexanediol, 1,2-pentanediol, octyldecanol or ethylhexylglycerol;

[0051] Preferably, the pH regulator includes any one or a combination of at least two of sodium hydroxide, potassium hydroxide, tromethamine, ammediol, citric acid, sodium citrate;

[0052] Preferably, the fragrance includes essence.

[0053] In a second aspect, the present invention provides a method for preparing the anti-acne suspended oil essence as described in the first aspect. The preparation method includes mixing oil, salicylic acid and oil-soluble anti-acne components to obtain an oil phase; mixing a thickener, a humectant, water-soluble anti-acne components and water to obtain an aqueous phase; and mixing the oil phase and the aqueous phase to obtain the anti-acne suspended oil essence.

[0054] Preferably, the preparation method includes:

[0055] (1) Mixing a thickener, a humectant and deionized water, heating and stirring until in a uniform state without particles, cooling and then adding water-soluble anti-acne components, and stirring evenly to obtain an aqueous phase;

[0056] Mixing salicylic acid and oil, stirring and heating until completely dissolved, cooling and then adding oil-soluble anti-acne components, and stirring evenly to obtain an oil phase;

[0057] (3) Adding the oil phase to the aqueous phase, stirring evenly and then standing to obtain the anti-acne suspended oil essence.

[0058] Preferably, when preparing the aqueous phase in step (1), the heating temperature is 65 - 80°C, for example, it can be 66°C, 68°C, 70°C, 72°C, 74°C, 76°C or 78°C, etc.

[0059] Preferably, when preparing the aqueous phase in step (1), the heating is carried out in a stirring manner, and the stirring speed is 3000 - 5000 rpm, for example, it can be 3200 rpm, 3500 rpm, 3800 rpm, 4000 rpm, 4200 rpm, 4500 rpm or 4800 rpm, etc.

[0060] Preferably, when preparing the aqueous phase in step (1), the cooling is to 30 - 40°C, for example, it can be 32°C, 34°C, 36°C, 38°C or 39°C, etc.

[0061] Preferably, after adding the water-soluble anti-acne components in step (1), it further includes adding any one or a combination of at least two of a preservative, a pH regulator or a fragrance.

[0062] Preferably, after obtaining the aqueous phase in step (1), the density of the aqueous phase is detected using a pycnometer.

[0063] When preparing the oil phase in step (1), the heating temperature is 65 - 80°C, for example, it can be 66°C, 68°C, 70°C, 72°C, 74°C, 76°C or 78°C, etc.

[0064] Preferably, during the preparation of the oil phase in step (1), the mixing is carried out in a stirring manner, and the stirring speed is 250-500 rpm, for example, it can be 280 rpm, 300 rpm, 350 rpm, 380 rpm, 400 rpm, 450 rpm or 480 rpm.

[0065] Preferably, during the preparation of the oil phase in step (1), the temperature is lowered to 30-40°C, for example, 31°C, 33°C, 35°C, 37°C or 39°C.

[0066] Preferably, in step (1), the density of the oil phase ρoil needs to be adjusted to be equal to the density of the water phase ρwater±0.1.

[0067] Preferably, the step of adjusting the density of the oil phase is: consulting the data to obtain the density of each oil in the oil phase, and then adjusting the density of the oil phase by adjusting the amount of oil added;

[0068] Preferably, the stirring speed in step (2) is 200-400 rpm, for example, it can be 220 rpm, 240 rpm, 260 rpm, 280 rpm, 300 rpm, 320 rpm, 340 rpm, 360 rpm or 380 rpm, etc.

[0069] Preferably, the standing time in step (2) is 0.5-2 h, for example, it can be 0.6 h, 0.8 h, 1 h, 1.2 h, 1.4 h, 1.6 h or 1.8 h.

[0070] Any specific point value within the above numerical range can be selected, and will not be described in detail here.

[0071] Compared with the prior art, the present invention has the following beneficial effects:

[0072] (1) The anti-acne oil suspension essence provided by the present invention is more effective in removing acne than a single aqueous anti-acne essence by combining salicylic acid, oil-soluble anti-acne ingredients and water-soluble anti-acne ingredients. In addition, the oil phase of the product can be suspended in the water phase, and the coexistence of the oil and water phases is achieved without adding an emulsifier, thereby reducing the irritation caused by the emulsifier and being friendly to acne-prone skin, especially sensitive acne-prone skin.

[0073] (2) The product of the present invention dissolves salicylic acid in an oil phase and then suspends the dissolved salicylic acid in an aqueous phase, thereby solving the problem of salicylic acid being easily precipitated in an aqueous phase. After the product contacts the skin, salicylic acid will not be completely exposed to the skin after water evaporates, thus causing irritation. In addition, the product of the present invention has a wider range of choices for aqueous phase thickeners, which can greatly reduce the amount of thickener used, thereby making consumers feel refreshed and non-greasy after use.

[0074] (3) The product of the present invention has a novel appearance of suspended oil droplets, which can meet the diverse aesthetic needs of consumers. Detailed implementation manners

[0075] To further elaborate on the technical means and effects adopted by the present invention, the following further illustrates the technical solution of the present invention in conjunction with the preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0076] The information of some materials involved in the following embodiments and comparative examples is as follows:

[0077]

[0078]

[0079] As long as the remaining raw materials are purchased from regular distributors, they can all be used.

[0080] Example 1

[0081] This example provides an anti-acne suspended oil essence, and the anti-acne suspended oil essence includes an oil phase and a water phase, and is calculated by weight parts as follows:

[0082]

[0083] The preparation method of the anti-acne suspended oil essence is as follows:

[0084] (1) Mix the thickener, moisturizer and deionized water, heat to 75 °C, homogenize at a rotation speed of 4000 rpm until it is in a uniform state without particles, cool down to 40 °C, add the water-soluble anti-acne component, and stir evenly to obtain the water phase;

[0085] (2) Mix salicylic acid and oil, heat to 75 °C, stir until completely dissolved, cool down to 40 °C, add the oil-soluble anti-acne component, and stir evenly at a rotation speed of 300 rpm to obtain the oil phase;

[0086] (3) Add the oil phase to the water phase, stir evenly at a rotation speed of 300 rpm, and then stand for 2 h to obtain the anti-acne suspended oil essence;

[0087] Example 2

[0088] This example provides an anti-acne suspended oil essence, and the anti-acne suspended oil essence includes an oil phase and a water phase, and is calculated by weight parts as follows:

[0089]

[0090]

[0091] The preparation method of the anti-acne suspended oil essence is as follows:

[0092] (1) Mix the thickener, humectant and deionized water, heat to 80 °C, homogenize at 4000 rpm until it reaches a particle-free and uniform state, cool down to 35 °C, add the water-soluble acne-removing ingredient, and stir evenly to obtain the aqueous phase;

[0093] (2) Mix salicylic acid with the oil, heat to 80 °C, stir until completely dissolved, cool down to 35 °C, add the oil-soluble acne-removing ingredient, and stir evenly at 300 rpm to obtain the oil phase;

[0094] (3) Add the oil phase to the aqueous phase, stir evenly at 300 rpm, and let it stand for 2 h to obtain the acne-removing oil-in-suspension essence.

[0095] Example 3

[0096] This example provides an acne-removing oil-in-suspension essence, and the acne-removing oil-in-suspension essence includes an oil phase and an aqueous phase, and is as follows by weight:

[0097]

[0098]

[0099] The preparation method of the acne-removing oil-in-suspension essence is as follows:

[0100] (1) Mix the thickener, humectant and deionized water, heat to 75 °C, homogenize at 5000 rpm until it reaches a particle-free and uniform state, cool down to 40 °C, add the water-soluble acne-removing ingredient, and stir evenly to obtain the aqueous phase;

[0101] (2) Mix salicylic acid with the oil, heat to 75 °C, stir until completely dissolved, cool down to 40 °C, add the oil-soluble acne-removing ingredient, and stir evenly at 400 rpm to obtain the oil phase;

[0102] (3) Add the oil phase to the aqueous phase, stir evenly at 400 rpm, and let it stand for 2 h to obtain the acne-removing oil-in-suspension essence.

[0103] Example 4

[0104] This example provides an acne-removing oil-in-suspension essence, and the acne-removing oil-in-suspension essence includes an oil phase and an aqueous phase, and is as follows by weight:

[0105]

[0106] The preparation method of the acne-removing oil-in-suspension essence refers to Example 1.

[0107] Example 5

[0108] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Embodiment 1 is only that the oil-soluble anti-acne component does not include octanoyl salicylic acid, and its reduced amount is supplemented by bisabolol, and the remaining components are the same as those of Embodiment 1, and the preparation method refers to Embodiment 1.

[0109] Embodiment 6

[0110] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Embodiment 1 is only that the oil-soluble anti-acne component does not include bisabolol, and its reduced amount is supplemented by octanoyl salicylic acid, and the remaining components are the same as those of Embodiment 1, and the preparation method refers to Embodiment 1.

[0111] Embodiment 7

[0112] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Embodiment 1 is only that the water-soluble anti-acne component does not include portulaca oleracea extract, and its reduced amount is distributed proportionally by weight to bordeaux leaf extract and hydrolyzed royal jelly protein, and the remaining components are the same as those of Embodiment 1, and the preparation method refers to Embodiment 1.

[0113] Embodiment 8

[0114] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Embodiment 1 is only that the water-soluble anti-acne component does not include bordeaux leaf extract, and its reduced amount is distributed proportionally by weight to portulaca oleracea extract and hydrolyzed royal jelly protein, and the remaining components are the same as those of Embodiment 1, and the preparation method refers to Embodiment 1.

[0115] Embodiment 9

[0116] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Embodiment 1 is only that the water-soluble anti-acne component does not include hydrolyzed royal jelly protein, and its reduced amount is distributed proportionally by weight to portulaca oleracea extract and bordeaux leaf extract, and the remaining components are the same as those of Embodiment 1, and the preparation method refers to Embodiment 1.

[0117] Embodiment 10

[0118] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Embodiment 1 is only that the oil does not include PPG-14 butyl ether, and its reduced amount is distributed proportionally by weight to propylene glycol dibenzoate and C12-15 alkyl benzoate, and the remaining components are the same as those of Embodiment 1, and the preparation method refers to Embodiment 1.

[0119] Embodiment 11

[0120] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Example 1 is only that the grease does not include propylene glycol dibenzoate, and the reduced amount is proportionally distributed to PPG-14 butyl ether and C12-15 alkyl benzoate. The other components are the same as those in Example 1, and the preparation method refers to Example 1.

[0121] Example 12

[0122] This embodiment provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Example 1 is only that the grease does not include C12-15 alkyl benzoate, and the reduced amount is proportionally distributed to PPG-14 butyl ether and propylene glycol dibenzoate. The other components are the same as those in Example 1, and the preparation method refers to Example 1.

[0123] Comparative Example 1

[0124] This comparative example provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Example 1 is only that it does not include oil-soluble anti-acne components, and the reduced amount is supplemented with deionized water. The other components and their addition amounts are the same as those in Example 1, and the preparation method refers to Example 1.

[0125] Comparative Example 2

[0126] This comparative example provides an anti-acne suspended oil essence. The difference between this anti-acne suspended oil essence and that of Example 1 is only that it does not include water-soluble anti-acne components, and the reduced amount is supplemented with deionized water. The other components and their addition amounts are the same as those in Example 1, and the preparation method refers to Example 1.

[0127] Comparative Example 3

[0128] This comparative example provides an anti-acne essence, which is a homogeneous single phase and is as follows by weight parts:

[0129]

[0130]

[0131] The preparation method of this anti-acne essence is the preparation method of ordinary essence type anti-acne products.

[0132] Test Example 1. Stability evaluation

[0133] Test objects: The anti-acne suspended oil essence prepared in Examples 1-12 and Comparative Examples 1-3.

[0134] Test method: Place the anti-acne suspended oil essence at 45°C for 24 h, then at room temperature for 24 h, and then at 5°C for 24 h, and cycle 3 times in sequence. Observe whether there is stratification, whether there are crystals precipitated, and whether the oil beads disappear. The test results are shown in Table 1.

[0135] Table 1

[0136]

[0137]

[0138] As can be seen from the data in Table 1, the anti-acne suspension oil essence provided by the embodiments of the present invention all has good stability. From the stability data of Examples 10 and 11, it can be seen that when the oil is not the specific combination of the present invention, the oil phase and water phase of the suspension oil anti-acne essence will separate (subsequent tests will not be carried out); from the stability data of Comparative Example 3, it can be seen that the stability of salicylic acid dissolved in the water phase is poor and it is easy to precipitate (subsequent tests will not be carried out).

[0139] Test Example 2: Irritation test

[0140] Thirty volunteers aged 18 - 55 were selected, and each subject tried the products of Examples 1 - 9, 12 and Comparative Examples 1 - 2 for skin patch tests.

[0141] Test method: Select a qualified patch tester. Using the closed patch test method, add about 0.020 mL - 0.025 mL of the test sample to the patch tester, and apply it to the flexor side of the forearm of the subject with a special external tape. After 24 hours, remove the test substance, and observe the skin reaction at 30 minutes, 24 hours, and 48 hours after removal respectively. Record the results according to the skin reaction grading standard (Table 2) in the "Cosmetics Safety and Technology Specifications" (2015 edition).

[0142] Table 2 Skin reaction grading standard for skin closed patch test

[0143]

[0144] The patch test results are shown in Table 3:

[0145] Table 3 Skin patch test results

[0146]

[0147]

[0148] As can be seen from the data in Table 3, the anti-acne suspension oil essence provided by the embodiments of the present invention is non-irritating, indicating that the anti-acne products provided by the present invention are safe and mild.

[0149] Test Example 3: Anti-acne efficacy test

[0150] One hundred and twenty volunteers aged 18 - 45 with facial acne grades 1 - 2 were selected and randomly divided into 12 groups, with 10 volunteers in each group. The 12 groups of volunteers were continuously used the products of Examples 1 - 9, 12 and Comparative Examples 1 - 2 for 14 days for anti-acne efficacy testing.

[0151] The test method is as follows: The test samples are continuously used by the subjects for 14 days under the guidance of the staff, and the test intervals are D0, D1, D7, and D14; the heme values of the facial acne of the subjects are tested by a facial image analyzer VISA-CR and a Mexameter MX18 (melanin and heme test probe), and the reduction of acne and the decrease in recurrence frequency are evaluated through the self-assessment questionnaire of the subjects.

[0152] The test results of the acne-removing efficacy are shown in Table 4 (all data are presented in the form of averages):

[0153] Table 4 Test Results of Acne-Removing Efficacy

[0154]

[0155]

[0156] It can be seen from the data in Table 4: By comparing the data of Examples 1-9 and 12, the acne-removing suspension oil essence of the present invention has excellent acne-removing efficacy. After 14 days of use, the number of comedones has decreased. Among them, the acne-removing suspension oil essence provided in Example 1 has the best acne-removing effect. After 14 days of use, the comedone reduction rate reaches more than 38%; from Comparative Application Examples 1-2, it can be seen that when the oil-soluble acne-removing component or water-soluble acne-removing component is missing in the acne-removing suspension essence of the present invention, the acne-removing effect of the product will be greatly reduced. From Comparative Example 3, it can be seen that when salicylic acid is dissolved in the aqueous phase to prepare the acne-removing essence, the acne-removing effect of the product will be reduced.

[0157] The applicant declares that the present invention uses the above-mentioned examples to illustrate an acne-removing suspension oil essence and its preparation method of the present invention, but the present invention is not limited to the above-mentioned examples, that is, it does not mean that the present invention must rely on the above-mentioned examples to be implemented. Those skilled in the art should understand that any improvement of the present invention, the equivalent replacement of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0158] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept scope of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0159] In addition, it should be noted that, in the case of no contradiction, the various specific technical features described in the above specific embodiments can be combined in any suitable manner. In order to avoid unnecessary repetition, the present invention will not separately describe various possible combination methods.

Claims

1. An anti-acne oil suspension essence, characterized in that: The anti-acne oil suspension essence comprises a water phase and oil phase particles dispersed in the water phase; The oil phase contains oil, salicylic acid and oil-soluble anti-acne ingredients; The water phase comprises a thickener, a moisturizer, a water-soluble anti-acne ingredient and water.

2. The anti-acne oil suspension essence according to claim 1, characterized in that: The anti-acne oil suspension essence comprises 1-15 parts of an oil phase and 85-99 parts of a water phase by weight; Preferably, the oil phase comprises 1-13 parts of oil, 0.1-2 parts of salicylic acid and 0.01-3 parts of oil-soluble anti-acne ingredients by weight; Preferably, the aqueous phase comprises, by weight, 0.01-1 parts of a thickener, 0.1-10 parts of a moisturizer, 0.01-10 parts of a water-soluble anti-acne ingredient, and 75-99 parts of water.

3. The anti-acne oil suspension essence according to claim 1 or 2, characterized in that: The oil comprises any one of PPG-14 butyl ether, propylene glycol dibenzoate, isononyl isononanoate, triethylhexanoin, caprylic / capric triglyceride, C12-15 alcohol benzoate, isopropyl myristate, isopropyl myristate, isopropyl isostearate, ethylhexyl palmitate, ethylhexyl stearate, glyceryl isostearate, olive oil, sunflower seed oil, jojoba seed oil, grape seed oil, macadamia seed oil, squalane, hydrogenated polyisobutene, dicaprylyl carbonate or dipropylene glycol dibenzoate, or a combination of at least two thereof; Preferably, the oil is a combination of PPG-14 butyl ether, propylene glycol dibenzoate and C12-15 alcohol benzoate; Preferably, the mass ratio of PPG-14 butyl ether, propylene glycol dibenzoate and C12-15 alcohol benzoate is (1.5-3):(1-2):(1-2); Preferably, the oil-soluble anti-acne ingredient includes any one or a combination of at least two of capryloyl salicylic acid, cymene, peony seed oil, tea tree essential oil, ylang-ylang flower oil, melaleuca alternifolia leaf oil, bisabolol, ginger root extract, stearyl glycyrrhizinate, lithospermum root extract or lavender oil; Preferably, the oil-soluble anti-acne ingredient is a combination of capryloyl salicylic acid and bisabolol; Preferably, the mass ratio of the capryloylsalicylic acid to bisabolol is (0.2-0.5):(0.1-0.2).

4. The anti-acne oil suspension essence according to any one of claims 1 to 3, characterized in that: The thickener includes any one of sphingomonas fermentation product extract, carbomer, xanthan gum, gellan gum, hydroxyethyl cellulose, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer, sodium polyacryloyldimethyl taurate, polyacrylate crosspolymer-6 or any one of polyacryloyldimethyl taurate or a combination of at least two thereof; Preferably, the moisturizing agent includes any one of glycerin, butylene glycol, dipropylene glycol, sodium hyaluronate, allantoin, trehalose, polyglycerol, maltitol, betaine, glucose, glyceryl glucoside or panthenol, or a combination of at least two thereof.

5. The anti-acne oil suspension essence according to any one of claims 1 to 4, characterized in that: The water-soluble acne-removing ingredient comprises any one of fruit acid, dipotassium glycyrrhizinate, purslane extract, phellodendron bark extract, sophora flavescens extract, scutellaria baicalensis extract, bombyx batryticatus extract, zanthoxylum fruit extract, peony root extract, centella asiatica extract, guaiac wood extract, olive leaf extract, witch hazel extract, tea extract, totarol, atractylodes macrocephala root extract, quaternary ammonium salt-73, yellow lotus extract, honeysuckle flower extract, salvia miltiorrhiza root extract, moringa seed extract, Norway spruce leaf extract, mango leaf extract, linear aspalathus linearis extract, ophiopogon root extract, PCA zinc, physalis sylvestris fruit extract, mahogany seed extract, Pichia pastoris fermentation lysate filtrate, ginsenoside CK, hydrolyzed royal jelly protein, citrus fruit extract or Bordeaux leaf extract, or a combination of at least two thereof; Preferably, the water-soluble anti-acne ingredient is a combination of purslane extract, Bordeaux leaf extract, and hydrolyzed royal jelly protein; Preferably, the mass ratio of the purslane extract, the Bordeaux leaf extract, and the hydrolyzed royal jelly protein is (1-5):(0.5-2):(0.5-2).

6. The anti-acne oil suspension essence according to any one of claims 1 to 5, characterized in that: The aqueous phase further comprises any one or a combination of at least two of a preservative, a pH adjuster or a fragrance; Preferably, the preservative comprises any one or a combination of at least two of p-hydroxyacetophenone, phenoxyethanol, 1,2-hexanediol, 1,2-pentanediol, caprylyl glycol or ethylhexylglycerin; Preferably, the pH regulator comprises any one of sodium hydroxide, potassium hydroxide, tromethamine, aminomethyl propanol, citric acid, sodium citrate, or a combination of at least two thereof; Preferably, the fragrance comprises essence.

7. A method for preparing the anti-acne oil suspension essence according to any one of claims 1 to 6, characterized in that: The preparation method comprises mixing oil, salicylic acid and oil-soluble anti-acne ingredients to obtain an oil phase; mixing a thickener, a moisturizer, a water-soluble anti-acne ingredient and water to obtain an aqueous phase; and mixing the oil phase and the aqueous phase to obtain the anti-acne suspension oil essence.

8. The preparation method according to claim 7, characterized in that: The preparation method comprises: (1) mixing a thickener, a moisturizer and deionized water, heating and stirring until the mixture is uniform without particles, adding a water-soluble anti-acne ingredient after cooling, and stirring to obtain an aqueous phase; Mix salicylic acid and oil, stir and heat until completely dissolved, add oil-soluble acne-removing ingredients after cooling, stir evenly to obtain an oil phase; (2) adding the oil phase to the water phase, stirring evenly and then letting it stand to obtain the anti-acne oil suspension essence.

9. The preparation method according to claim 8, characterized in that: The heating temperature during the preparation of the aqueous phase in step (1) is 65-80° C.; Preferably, in step (1) of preparing the aqueous phase, the mixing is performed by stirring at a speed of 3000-5000 rpm; Preferably, in step (1), the water phase is cooled to 30-40° C. during preparation; Preferably, after adding the water-soluble acne-removing ingredient in step (1), the step further includes adding any one or a combination of at least two of a preservative, a pH adjuster or a fragrance; Preferably, after obtaining the aqueous phase in step (1), the density of the aqueous phase is detected using a pycnometer.

10. The preparation method according to claim 8 or 9, characterized in that: The heating temperature during the preparation of the oil phase in step (1) is 65-80° C.; Preferably, in step (1) of preparing the oil phase, the mixing is carried out in a stirring manner, and the stirring speed is 250-500 rpm; Preferably, in step (1), the temperature is lowered to 30-40° C. during the preparation of the oil phase; Preferably, in step (1), the density of the oil phase ρoil=the density of the water phase ρwater±0.1; Preferably, the step of adjusting the density of the oil phase is: consulting the data to obtain the density of each oil in the oil phase, and then adjusting the density of the oil phase by adjusting the amount of oil added; Preferably, the stirring speed in step (2) is 200-400 rpm; Preferably, the standing time in step (2) is 0.5-2h.

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