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Biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material as well as production method and application thereof

A mg-si-sr-ca, biomedical technology, applied in medical science, prosthesis, etc., can solve the problem of comprehensive performance to be improved, and achieve the effect of high biological safety

Active Publication Date: 2013-05-15
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many multi-element magnesium alloys that meet the requirements of biocompatibility, such as Mg-Mn-Zn, Mg-Zn-Ca, Mg-Zn-Mn-Ca, etc., but the comprehensive properties of these materials still need to be improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-12

[0042] In embodiment 1-12, the preparation method of magnesium alloy is as follows:

[0043] (1) Weigh pure magnesium, pure silicon, pure strontium and pure calcium in proportion;

[0044] (2) Dry the above materials in an oven at 100°C for 1 hour;

[0045] (3) Put pure magnesium in a low-carbon steel crucible and heat it in a resistance furnace at 720°C for 20-30 minutes until the pure magnesium is completely melted;

[0046] (4) Quickly add the dried pure calcium and pure silicon into the pure magnesium melt, stir once every 10 minutes, stir 4 times in total, and smelt for a total of 50 minutes to obtain solution A;

[0047] (5) Heat the resistance furnace to 740°C, quickly add dried pure strontium into solution A, stir once every 10 minutes, stir 3 times in total, and melt for a total of 40 minutes to obtain solution B;

[0048] (6) After smelting, pour the alloy melt into the pre-dried graphite mold to obtain Mg-Si-Sr-Ca multi-element magnesium alloy material;

[0049] ...

Embodiment 1

[0051] In this embodiment, the components and weight percentages of the multi-component Mg-Si-Sr-Ca alloy material are: Si0.5%, Sr0.25%, Ca0.5%, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight, and the total is not more than 0.4%. The purity of the raw material Mg is not lower than 99.99wt%, the purity of Si is not lower than 99.99wt%, the purity of Sr is not lower than 99.99wt%, and the purity of Ca is not lower than 99.75wt%. After 99-99.5% CO by volume 2 and 0.5-1.0%SF 6 (Sulfur hexafluoride) high-cleanliness smelting and casting in a protective atmosphere, followed by heat treatment and extrusion processing. In this example, the Mg-Si-Sr-Ca multi-element magnesium alloy material obtained according to the above preparation method was placed in a vacuum tube Solid solution treatment is carried out in a type furnace, the solution temperature is 400°C, t...

Embodiment 2

[0054] In this embodiment, the components and weight percentages of the multi-component Mg-Si-Sr-Ca alloy material are: Si0.8%, Sr0.5%, Ca1.0%, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight, and the total is not more than 0.4%. The purity of the raw material Mg is not lower than 99.99wt%, the purity of Si is not lower than 99.99wt%, the purity of Sr is not lower than 99.99wt%, and the purity of Ca is not lower than 99.75wt%. After 99-99.5% CO by volume 2 and 0.5-1.0%SF 6 (Sulfur hexafluoride) high-cleanliness smelting and casting in a protective atmosphere, followed by heat treatment and extrusion processing. In this example, the Mg-Si-Sr-Ca multi-element magnesium alloy material obtained according to the above preparation method was placed in a vacuum tube Solid solution treatment is carried out in a type furnace, the solution temperature is 280°C, th...

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Abstract

The invention relates to a biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material as well as a production method and application thereof. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material is suitable for being used as an implant material used in a human body environment. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material comprises the following components in percentage by weight: 0.1%-20.0% of Si, 0.1%-8.0% of Sr, 0.1%-10.0% of Ca and the balance of Mg. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material is a multi-element magnesium alloy system consisting of total nutrient elements of Mg, Si, Sr and Ca; the form, quantity and distribution of a plurality of second phases such as Mg2Si, Mg2Sr, Mg17Sr2, Mg2Ca, CaMgSi and the like in the magnesium alloy are controlled, so that the multi-element magnesium alloy with the optical comprehensive performances is obtained. The biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material disclosed by the invention has good biocompatibility and mechanical properties, and is a biodegradable magnesium alloy material with excellent comprehensive performances. Besides, the biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material has a high application value in the fields such as interventional therapy for cardiovascular diseases, intraosseous implant and the like.

Description

technical field [0001] The invention relates to a biomedical absorbable Mg-Si-Sr-Ca multi-element magnesium alloy material and its production method and application, which is suitable as an implant material used in the human body environment. Background technique [0002] In recent years, magnesium and magnesium alloys, as new biodegradable medical materials, have become a research hotspot in the field of biomaterials. Magnesium is an indispensable and important nutritional element in the human body. It participates in a series of metabolic processes in the body and is closely related to the functions of nerves, muscles and heart. Magnesium alloy has high specific strength and specific stiffness, and its strength can exceed 200MPa; the density of pure magnesium is 1.74g / cm 3 About, and the compact bone density of human bone (1.75g / cm 3 ) is equivalent; the Young's modulus of magnesium alloy is about 45GPa, which is close to the elastic modulus of human bone (about 20GPa), ...

Claims

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Application Information

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IPC IPC(8): C22C23/00C22C1/02C22F1/06A61L27/04
Inventor 刘辰谭丽丽杨柯万鹏于晓明
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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