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Stent made of bio-degradable magnesium alloy with magnesium fluoride coating and organic coating

An organic coating, magnesium alloy technology, applied in coating, medical science, surgery, etc., can solve problems such as cracks, coating increase, etc.

Pending Publication Date: 2019-08-16
MEKO LASERSTRAHL MATERIALBEARBEITUNGEN EK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these properties are desirable for absorbable implants, however, the following problems exist in the prior art: although the purpose of absorbing the implanted scaffold is achieved in principle, there is still the possibility of temporary non-specific degradation of the scaffold. question
For a sufficiently long resistance, however, layer thicknesses of more than 150 μm are required, whereby increased cracks in the coating may arise due to the dynamic loading of the scaffold

Method used

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  • Stent made of bio-degradable magnesium alloy with magnesium fluoride coating and organic coating
  • Stent made of bio-degradable magnesium alloy with magnesium fluoride coating and organic coating
  • Stent made of bio-degradable magnesium alloy with magnesium fluoride coating and organic coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0490] Embodiment 1: the preparation of alloy

[0491] The alloy is produced by the so-called permanent mold direct chill casting method ("Tütengu βverfahren"). This method is used to prepare precursor materials for subsequent extrusion and is characterized in that said materials have a uniform microstructure and that ingots with a uniform distribution of alloying elements can be produced. Therefore, it is extremely suitable for the production of smaller quantities of high-value cylinders for forming.

[0492] In the case of this method, magnesium alloys (L1, L2, ..., L44) are melted in smooth steel crucibles. As crucible material virtually any nickel-free steel can be used. Graphite is another possible material. All melting operations were performed under protective gas. The melting bath temperature here is 660-740°C. When the temperature of the molten bath is reached, the alloying elements are added in the form of pure elements or master alloys. After addition of alloy...

Embodiment 2

[0601] Embodiment 2: the preparation of tubing

[0602] Extruded wires were produced from alloys L1 to L10 according to Example 1. In these extruded wires, precision holes are introduced in the longitudinal direction, which already collectively determine the wall thickness of the subsequent stent. Through several forming steps, a tube with a predetermined diameter and a defined wall thickness is produced. Between the individual forming steps, repeated heat treatments are carried out.

Embodiment 3

[0603] Example 3: Stent Fabrication

[0604] The tubes produced according to Example 2 were fastened on the receivers (Aufnahme) of the laser machine. A pulsed solid-state laser (FKL) cuts the outline of the stent design from the tubing. Laser cutting is performed under a protective gas atmosphere.

[0605] The scaffold design is stored in an NC (Numerical Control) program. It provides the path of travel for the laser, thereby structuring the tube. Cutting with the laser beam produces burrs in particular on the inner side of the tube along the entire cutting contour. This can lead to residues and swarf in the profile after the cutting process is complete. Mechanically remove residues and cuttings, and clean preparation residues from scaffolds. In the first optical vision control, a cutting contour check is performed.

[0606] Next, the stent is electrochemically polished. Connect the support as an anode and immerse it in an acid bath. The circuit is closed by the catho...

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Abstract

The present invention relates to stents which are produced from a magnesium alloy, which is degradable under physiological conditions, having an inorganic coating comprising magnesium fluoride and anorganic coating. The stents according to the invention can additionally be coated with at least one anti-inflammatory, anti-proliferative, anti-angiogenic, anti-restenotic and / or anti-thrombogenic active substance.

Description

technical field [0001] The present invention relates to a stent made of a magnesium alloy degradable under physiological conditions with an inorganic coating comprising magnesium fluoride and with an organic coating. In this case, the stent according to the invention can additionally be coated with at least one anti-inflammatory, anti-proliferative, anti-angiogenic, anti-restenotic and / or anti-coagulant active ingredient. Background technique [0002] Implantation of vascular supports such as stents is currently a common surgical intervention for the treatment of stenosis. They are usually made of metal alloys such as stainless steel or Nitinol. A large number of such metal supports are known and have proven useful in practice. Due to its metal structure and load-bearing capacity, such a metal stent should ensure that the vessel remains open after implantation and permanently ensure blood flow through the vessel. [0003] However, recent studies have shown that narrowed v...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/08A61L31/14
CPCA61L31/028A61L31/088A61L31/148A61L2420/08A61L31/022A61L31/10A61L31/16A61L2300/216A61L2300/416A61L33/0005
Inventor C·米尔-柯伯M·斯泰克R·曼泽
Owner MEKO LASERSTRAHL MATERIALBEARBEITUNGEN EK
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