Method for preparing biodegradable magnesium alloy intravascular stent

Abstract

The invention discloses a method for preparing a biodegradable magnesium alloy intravascular stent in the technical field of biological materials. The method comprises the following steps of: performing stress relief annealing treatment on a magnesium alloy extrusion bar of phi20mm; processing the annealed bar into a tube blank, and extruding the tube blank; performing stress relief annealing treatment on the extruded capillary tube; cutting the annealed capillary tube to form a stent blank by laser; acid-washing and ultrasonically cleaning the cut stent in an ultrasonic cleaner to remove thecut residues; and performing electrochemical polish, ultrasonic cleaning and passivation on the stent. The extruded magnesium alloy capillary tube has uniform tube wall thickness and smooth surface, the tensile strength of the capillary tube can reach 320 to 370MPa, the yield strength can reach 260 to 300MPa, the elongation can reach 24 to 30 percent, and the corrosion rate of the capillary tube in simulated body fluid is 0.14 to 0.24mm / year. The polished intravascular stent has flat, smooth and bright internal and external surfaces. The preparation method provided by the invention can prepare the biodegradable intravascular stent meeting the clinical requirement.

Description

technical field The invention relates to a preparation method in the technical field of biomaterials, in particular to a preparation method for a biodegradable magnesium alloy intravascular stent. Background technique In the field of cardiovascular disease treatment, interventional stent therapy has become the most important means. However, the current clinical application of cardiovascular stents is still mainly made of non-degradable metal materials, such as stainless steel, nickel-titanium alloy or cobalt-chromium alloy. The permanent existence of these stents will cause permanent physical stimulation to the vessel wall, mismatch with the mechanical properties of non-implanted vessels, intimal hyperplasia after long-term implantation, inability to guide postoperative vascular regeneration, and the release of heavy metal ions. Insufficient local inflammatory response. In order to solve the limitations of traditional metal stents, biodegradable materials are used as intra...

AI Technical Summary

Problems solved by technology

The invention solves the problems caused by the non-degradability of the current clinical metal vascular stent in the body, and the complex processing method of the existing magnesium alloy vascular stent, and the preparation of the biodegradable magnesium alloy vascular stent with simple process and easy implementation craft

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