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Method for preparing biodegradable magnesium or magnesium alloy and tricalcium phosphate composite material

A tricalcium phosphate, biodegradable technology, applied in medical science, prostheses, etc., can solve problems affecting performance, raw material oxidation, etc., and achieve the effects of low production cost, high interface bonding strength, and good connectivity

Inactive Publication Date: 2010-04-28
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the traditional powder metallurgy method, the powdery raw materials are prone to severe oxidation during sintering, which affects its performance.

Method used

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  • Method for preparing biodegradable magnesium or magnesium alloy and tricalcium phosphate composite material
  • Method for preparing biodegradable magnesium or magnesium alloy and tricalcium phosphate composite material
  • Method for preparing biodegradable magnesium or magnesium alloy and tricalcium phosphate composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one: prepare biodegradable magnesium and tricalcium phosphate composite material, its steps are as follows:

[0026] (1) Preparing the porous tricalcium phosphate body: preparing the porous tricalcium phosphate body by an organic foam impregnation method;

[0027] a. To pretreat the polyurethane sponge, first cut the polyurethane sponge into a shape of 2cm×2cm×1cm, then soak it in a 35% NaOH solution by weight, soak it at 60°C for 2h, and then wash it with water , dry for later use;

[0028] b. To prepare a polyvinyl alcohol (PVA) solution, first add polyvinyl alcohol: deionized water into the dissolution kettle in a ratio of 1:10 by mass, heat up to 95°C while stirring, and keep warm until the polyvinyl alcohol is completely dissolved in the deionized water. In deionized water, a PVA solution with a concentration of 0.1 g / ml was obtained;

[0029] c, prepare the tricalcium phosphate slurry, the tricalcium phosphate powder and the concentration are mixed in...

Embodiment 2

[0041] Embodiment two: prepare biodegradable magnesium-calcium alloy and tricalcium phosphate composite material, its steps are as follows:

[0042] (1) prepare the porous tricalcium phosphate body with a porosity of 86% by the same method as in Example 1;

[0043] (2) Infiltrate Mg-1.0Ca alloy: Mg-1.0Ca alloy (i.e. Ca weight percentage is about 1.0%, the rest is the alloy of Mg) is infiltrated in the porous tricalcium phosphate green body by melt infiltration method. yes:

[0044] a. Calculate the quality of the required alloy according to the porosity of the porous tricalcium phosphate body and the density of the Mg-1.0Ca alloy to be infiltrated, and in order to obtain a highly dense composite material, an excess of 10% Mg should be weighed -1.0Ca alloy, therefore, the weight M of required Mg-1.0Ca alloy is calculated as follows by formula (2):

[0045] M=4cm 3 ×86%×1.74g / cm 3 ×1.1≈6.6g

[0046] b. Place the porous tricalcium phosphate body in a corundum crucible, place...

Embodiment 3

[0048] Embodiment three: prepare biodegradable Mg-Zn-Mn alloy and tricalcium phosphate composite material, its steps are as follows:

[0049] (1) Preparing the porous tricalcium phosphate body: preparing the porous tricalcium phosphate body by an organic foam impregnation method;

[0050] a, pretreatment polyurethane sponge, different from embodiment one: polyurethane sponge is Φ50 * 20mm 3 The body, in the NaOH solution of 35% by weight, soaked at 60 ° C for 3 hours;

[0051] B, prepare polyvinyl alcohol (PVA) solution by the same method of embodiment one;

[0052] c, prepare tricalcium phosphate slurry, the difference with embodiment one is: the mixing ratio of tricalcium phosphate powder and PVA solution is to add 70g tricalcium phosphate powder in the PVA solution of 100ml, add 20ml dehydrated alcohol again, through ball milling Mix to prepare a tricalcium phosphate slurry with good fluidity;

[0053] d. Prepare a porous tricalcium phosphate green body. The difference f...

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Abstract

The invention discloses a method for preparing a biodegradable magnesium or magnesium alloy and tricalcium phosphate composite material, which comprises the following steps: (1) preparing a porous tricalcium phosphate blank, which is to prepare a porous tricalcium phosphate blank by using an organic foam impregnation method; and (2) permeating magnesium or a magnesium alloy, which is to permeate magnesium or a magnesium alloy into the porous tricalcium phosphate blank by using a fusant permeation method to preparing the magnesium or magnesium alloy and tricalcium phosphate composite material.The method has the advantages that: the prepared composite material has high degree of communication as well as well-guaranteed osteoinductive performance and biodegradability and can be used as material for hard tissue replacement and bone repair, completely degrade after being transplanted into a body for a certain time period and induce the formation of new bones; the production process is simple and does not need special equipment and production cost is low; and the method is suitable to prepare biodegradable composite materials with different properties.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable composite material, in particular to a preparation method of a biodegradable magnesium or magnesium alloy and tricalcium phosphate composite material. Background technique [0002] Magnesium is one of the essential macroelements of the human body, and the daily requirement of an adult is more than 350mg; it participates in a series of metabolic processes in the body, including the formation of bone cells, accelerating the healing of bone injuries, and so on. Using magnesium or magnesium alloys as hard tissue implant materials can ignore the toxicity of trace metal ions to cells, and the elastic modulus of magnesium or magnesium alloys is low (about 45GPa); therefore, the use of magnesium or magnesium alloys to develop metal implants The implanted material can solve the problems of stress shielding and harmful element dissolution in the implants of inert metal materials such as stainless s...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/58
Inventor 吴泽宏王勇周红
Owner CHONGQING UNIV
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