55 results about "Retinal implant" patented technology

A visible and infrared light powered retinal implant is disclosed that is implanted into the subretinal space for electrically inducing formed vision in the eye. The retinal implant includes a stacked microphotodetector arrangement having an image sensing pixel layer and a voltage and current gain adjustment layer for providing variable voltage and current gain to the implant so as to obtain better low light implant performance than the prior art, and to compensate for high retinal stimulation thresholds present in some retinal diseases. A first light filter is positioned on one of the microphotodetectors in each of the image sensing pixels of the implant, and a second light filter is positioned on the other of the microphotodetectors in the image sensing pixel of the implant, each of the microphotodetectors of the pixel to respond to a different wavelength of light to produce a sensation of darkness utilizing the first wavelength, and a sensation of light using the second wavelength, and a third light filter is positioned on a portion of the voltage and current gain adjustment layer that is exposed to light, to allow adjustment of the implant voltage and current gain of the device by use of a third wavelength of light.

An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).

A sensory substitution device according to an embodiment of the invention includes a thermal imaging array for sensing thermal characteristics of an external scene. The device includes a visual prosthesis adapted to receive input based on the scene sensed by the thermal imaging array and to convey information based on the scene to a user of the sensing device. The visual prosthesis is adapted to simultaneously convey to the user different visual information corresponding to portions of the scene having different thermal characteristics. One type of thermal imaging array includes a microbolometer imaging array, and one type of visual prosthesis includes a retinal implant. According to additional embodiments, an apparatus for obtaining thermal data includes a thermal detector adapted to sense thermal characteristics of an environment using a plurality of pixels. The apparatus also includes a pixel translator, operably coupled with the thermal detector, adapted to translate pixel data of the thermal detector to a lower resolution. The apparatus also includes an interface, operably coupled with the pixel translator, adapted to communicate the thermal characteristics of the environment to a user of the apparatus at a lower resolution than sensed by the thermal detector.

An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

In a method for introducing a retinal implant to a position within a subretinal region of an eye, the following steps are performed: a) preparing a fornix-based scleral flap at a distance from the limbus; b) detaching the retina by subretinal injection of balanced salt solution, from the vitreous cavity and creating a localized bubble in the area of the scleral flap; c) performing in the upper hemisphere of the eye a peripheral retinotomy and detaching a part of the retina; d) advancing the implant into the subretinal space and placing an inner portion of said implant on the retinal pigment epithelium onto the desired position; and e) closing the sclera flap.

An artificial retina device and a retinal stimulation system and method for stimulating and modulating its function is disclosed. The artificial retina device includes multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the artificial retina device, the nature of induced retinal images may be modulated and improved. The retinal stimulation system may be worn as a headset. Color images may be induced by programming the stimulating pulse durations and frequencies of the stimulation.

The retinal prosthesis test device is comprised of a thin wafer of glass made from nanochannel glass (NGC) with very small channels perpendicular to the plane of the wafer filled with an electrical conductor forming microwires. One surface of the glass is ground to a spherical shape consistent with the radius of curvature of the inside of the retina. The NGC is hybridized to a silicon de-multiplexer and a video image is serially input to a narrow, flexible micro-cable and read into a 2-D array of unit cells in a pixel-by-pixel manner which samples the analog video input and stores the value as a charge on a MOS capacitor. After all unit cells have been loaded with the pixel values for the current frame, a biphasic pulse is sent to each unit cell which modulates the pulse in proportion to the pixel value stored therein. Because the biphasic pulses flow in parallel to each unit cell from a global external connection, the adjacent retinal neurons are all stimulated simultaneously, analogous to image photons stimulating photoreceptors in a normal retina. A permanent retinal implant device uses a NGC array hybridized to a silicon chip, the image is simultaneously generated within each cell through a photon-to-electron conversion using a silicon photodiode. The photons propagate directly through into the backside of the device. Electrical power and any control signals are transmitted through an inductively driven coil or antenna on the chip. The device collects the charge in storage capacitors via the photon-to-electron conversion process, stimulates the neural tissue with biphasic pulses in proportion to the stored charges, and resets the storage capacitors to repeat the process.

A visible and infrared light powered retinal implant is disclosed that is implanted into the subretinal space for electrically inducing formed vision in the eye. The retinal implant includes a stacked microphotodetector arrangement having an image sensing pixel layer and a voltage and current gain adjustment layer for providing variable voltage and current gain to the implant so as to obtain better low light implant performance than the prior art, and to compensate for high retinal stimulation thresholds present in some retinal diseases. A first light filter is positioned on one of the microphotodetectors in each of the image sensing pixels of the implant, and a second light filter is positioned on the other of the microphotodetectors in the image sensing pixel of the implant, each of the microphotodetectors of the pixel to respond to a different wavelength of light to produce a sensation of darkness utilizing the first wavelength, and a sensation of light using the second wavelength, and a third light filter is positioned on a portion of the voltage and current gain adjustment layer that is exposed to light, to allow adjustment of the implant voltage and current gain of the device by use of a third wavelength of light.

A neuro-electronic interface device has a micro-electrode electrically connected to an interconnect that has scaling gradients between 1.1 and 1.9 over a scaling range of at least one order of magnitude. The device preferably has an array of such fractal interconnects in electrical contact with an array of micro-electrodes. Such fractal interconnect arrays may be components of implants including a retinal implant device having an array of photodetectors in electrical contact with the array of micro-electrodes. The interconnects may be fabricated by forming nanoscale particles and depositing them onto a non-conductive surface that is smooth except for electrodes which serve as nucleation sites for the formation of fractal interconnect structures through diffusion limited aggregation.

A retinal implant is provided that uses an artificial biocompatible material as a support material on which retinal pigment epithelial cells, iris pigment epithelial cells, and / or stem cells can be deposited either in situ or in vivo. The support material has a surface topology that is rough to promote cell adhesion, has surface pits to allow pigment cells to grow into, and has pores to allow for proper diffusion of materials. The support material serves as a substrate for cell growth and as a patch for damaged basement membrane (Bruch's membrane). This cell-coated membrane or pigment cell-enriched membrane is surgically positioned in the sub-retinal space to rescue or restore photoreceptor cell function that may be damaged or threatened by degenerative diseases of the eye, such as age-related macular degeneration.

An artificial retinal system includes an external optical device having an image generator and a background light generator, and a retinal implant chip having a solar cell and a stimulus generator. The stimulus generator is disposed to receive a target image projected by the image generator and a background light provided by the background light generator, and receives the electrical power from the solar cell. The stimulus generator includes an image sensing stimulator operable to convert the target image into electrical stimuli, and a contrast enhancer for reducing effect of the background light on the electrical stimuli.

A signal processing method is provided for processing a plurality of input frequency domain data within a frequency band, each of the input frequency domain data having magnitude and phase characteristics and being associated with a phase parameter that corresponds to the phase characteristic thereof. The method includes: arranging the input frequency domain data in sequence on a variable axis; rearranging positions of the input frequency domain data on the variable axis with reference to at least the phase parameters of the input frequency domain data; and combining the rearranged input frequency domain data that are disposed on the same position on the variable axis to result in processed frequency domain data. The signal processing method can preserve and transmit phase characteristics at various frequencies, and is suitable for application to cochlear implant systems, retinal implant systems, and multi-phase data transmission systems.

A method for manufacturing an intraocular retinal implant including: providing a mold capable of supporting growth of a layer of doped diamond, the mold including, on one face, elements all depressed or all projecting with respect to the surface of the face, and constituting a pattern cavity for the electrodes of the implant which it is desired to obtain; producing the doped diamond electrodes by growing a layer of doped diamond in all or part of a space occupied by the pattern cavity elements; forming a first insulating layer on the face of the mold including the pattern cavity; producing interconnection lines by depositing an electrically conductive material at least in spaces not covered by the first insulating layer; forming a second insulating layer on the mold face including the pattern cavity, the second layer covering the interconnection lines, the first and second insulating layers forming a flexible plate of the implant; removing the mold.

Diamond-like carbon films are deposited on devices for implantation in tissues of a living body, preferably, retinal implants. Openings may be formed in the diamond-like carbon film, preferably in alignment with portions of the device intended for electrical contact with surrounding tissues, i.e., electrodes. Alternatively, the diamond-like carbon film may be rendered electrically conductive. Furthermore, the diamond-like carbon films may be created in such a manner that they are substantially transparent to various wavelengths of electromagnetic radiation, including visible and / or infrared light. In a presently preferred embodiment, the diamond-like carbon film is deposited using a magnetically-filtered, cathodic arc physical vapor deposition process. Implantable devices, particularly retinal implants, comprising a diamond-like carbon film may exhibit excellent biocompatibility and biodurability properties in comparison with prior art devices and passivation coatings.

A retinal implant has at least one functional unit positioned internally inside an eye and at least one functional unit positioned externally outside the eye and at least one functional unit positioned outside the eye, which are separably connected to one another via a signal path in a manner designed for signal or data transmission. The patient's residual vision which may still remain is preserved because the signal path extends through the sclera of the eye and does not incorporate the anterior eye section.

The present invention relates to a microelectronics element, such as an optical receiver element, for a medical implant device to be implanted in the human or animal body, particularly for a retinal implant device. The microelectronics element comprises a functional unit including application specific microelectronics, such as a photodiode, for performing a function in the medical implant device, and rectifier means adapted for converting an AC supply voltage into a DC voltage. The DC voltage provided by the rectifier means, or an operating voltage derived from the DC voltage, is configured to be supplied to the functional unit. Further, the functional unit and the rectifier means are integrated on a common semiconductor substrate and configured such that the rectifier means isolates the microelectronics element from application of an external DC supply voltage. The invention also relates to a medical implant device, such as a retinal implant, which incorporates such a microelectronics element.

Apparatus is provided including an implantable retinal stimulator, for implantation on a retina of an eye, and including (i) an electrode array including electrodes; (ii) a plurality of photosensors; and (iii) driving circuitry, configured to drive the electrodes to apply currents to the retina. The apparatus further includes an interface member disposed at an outer surface of the implantable retinal stimulator, e.g., a peripheral member surrounding at least a portion of the implantable retinal stimulator. The apparatus additionally includes a frame, (i) shaped and sized to couple to the peripheral member and to surround the implantable retinal stimulator at least in part, and (ii) shaped to define at least a first anchoring element receiving portion. An anchoring element is shaped and sized to be positioned in the anchoring element receiving portion and to penetrate scleral tissue of the subject. Other applications are also described.

A method is provided for implanting, in an eye, apparatus having an electrode array including stimulating electrodes shaped to define distal tips protruding from the array, a plurality of photosensors, and driving circuitry, configured to drive the electrodes to apply currents to the retina. The method includes removing a lens of the eye and a vitreous body of the eye, creating a corneoscleral incision and inserting the apparatus through the corneoscleral incision into a vitreous cavity of the eye. During the inserting, an orientation of the distal tips is maintained pointing towards a cornea of the eye. Subsequently to the inserting, the apparatus is rotated such that the distal tips point towards a macula of the eye. Subsequently to the rotating, the apparatus is positioned epi-retinally, such that the distal tips of the electrodes penetrate the retina. Other applications are also described.

The invention discloses a flexible cable of a retinal prosthesis, which comprises a microelectrode, a plurality of stimulation electrodes, an abutting piece, a leading-in part and a connecting part, wherein the microelectrode is provided with a first mounting hole and an electrode region;the stimulation electrodes are arranged in the electrode region, and the end parts of the stimulation electrodes are exposed on one side surface of the microelectrode; the abutting piece is provided with a second mounting hole corresponding to the first mounting hole and extends to the back surfaces of the stimulation electrodes from the second mounting hole; the abutting piece is arranged on the other side surface of the microelectrode; force distribution obtained at the second mounting hole is transmitted to the back surfaces of the stimulation electrodes through elastic force generated by elastic denaturation, so that the electrodes are uniformly stressed, a better sticking effect is achieved, and the phenomena of inclination and warping of the electrodes caused by uneven stress are avoided.According to the flexible cable, the microelectrode can be uniformly stressed and can be better attached to the retina so as to obtain a more effective stimulation effect.The invention further discloses a retinal implant device and the retinal prosthesis.